Visual Abstract
Background: The presence of cardiometabolic risk factors in obesity, termed metabolically unhealthy obesity (MUHO), confers a ten-fold increased risk of type II diabetes (T2DM). The components of MUHO may originate in inflammatory and/or oxidative stress pathways. Yet, biomarkers within these pathways have rarely been explored to associate with incident MUHO. We examined relationships of adiponectin, c-reactive protein (CRP), and uric acid with incident MUHO over 15-years.
Methods: A total of 292 participants with obesity and ≤ 2 cardiometabolic risk factors from the CARDIA study (years 2000-2015) were included. MUHO was defined by the presence of ≥ 2 ATPIII metabolic syndrome criteria at 5, 10 and 15 year follow-up. Multilevel logistic regression controlled for age, sex, race/ethnicity. Secondary models examined relationships between biomarkers and each component of cardiometabolic risk.
Results: Results are provided in Table 1. A 4.9 pg/mL increase in adiponectin (+1SD) was associated with lower incidence of MUHO, HDL-C, and glucose. A 1.4 mg/mL increase in uric acid (+1SD) associated with incident metabolically unhealthy obesity and individual cardiometabolic risk factors. No significant associations were found with CRP.
Conclusions: Adiponectin and uric acid could help identify individuals with obesity at risk for developing MUHO and offer the opportunity to initiate preventive measures.
L. M. L. Corso: None. C. E. Lewis: None. M. R. Carnethon: None. S. M. Camhi: None. T. Huedo medina: None. J. Mccaffery: None.
