Visual Abstract

Background: Patients with diabetes mellitus (DM) are at increased risk for complications when hospitalized for COVID-19. We sought to investigate with the risk factors and clinical outcomes in diabetic patients hospitalized with COVID-19.

Methods: Clinical variables were analyzed retrospectively in a cohort of patients admitted with COVID-19 from 01/ 2020 to 06/2020. Patients were stratified by history of DM and compared using descriptive statistics, χ2, and Mann-Whitney tests.

Results: Among the 321 patients, 35% (114) had a history of DM with median age of 66.5[55-76]. Diabetic patients had a higher BMI 32[27-40] vs. 29 [24-34] (P<0.001), and a median HbA1c of 7.4% [6.3-9.4]. Comorbidities associated with DM were HTN, HLD, CKD, OSA, CKD (P<0.0001) and HFpEF (P=0.01). Compared to nondiabetics, DM patients had longer LOS, 8[4-14] vs. 5.5[3-11], (P <0.001) and a higher risk of cardiac arrest (CA), OR= 2.5[1.1-6] (P<0.001). Among DM patients, BNP>100 pg/ml was found in 90% (10) of DM patients with CA vs. 43.8% (48) in DM patient without CA (No CA) Fig1.

Conclusion: Hospitalized DM patients with COVID-19 with a BNP>100 pg/ml were at higher risk of CA. Identifying subclinical HF using BNP may be helpful in predicting and implementing strategies to lower adverse cardiovascular outcomes in DM patients hospitalized with COVID-19. Screening DM patients hospitalized with COVID-19 using BNP may be beneficial.

graphic
View largeDownload slide
Disclosure

A. Zain elabidin: None. K. Shemisa: Speaker’s Bureau; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Pfizer Inc. L. Pereira: None. V. Namdarizandi: None. M. Fatuyi: None. S. Kasan: None. V. Sharma: None. B. Tappuni: None. B. Kaseer: None. D. M. Brandt: None.

© 2021 by the American Diabetes Association
2021
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.