Objectives: Thyroid hormone has effects on cardiovascular system other than metabolism. This study aimed to investigate the association between thyroid hormone and Arterial stiffness (AS) in type 2 diabetes mellitus (T2DM).

Methods: 1064 T2DM patients were included in the cross-sectional study. They were divided into two groups: AS group (baPWV≥1550cm/s) and Non-AS group (baPWV<1550cm/s) or PAD group (ABI≤0.9)or Non-PAD group(ABI>0.9).

Results: 1) FT3, FT4, TT3 and TT4 were comparable (all P>0.05) while TSH were significantly higher in PAD group than Non-PAD group(2.19±1.86μIU/mL vs. 1.85±1.95μIU/mL, P=0.031). FT3 was significantly lower while TSH was significantly higher in AS group than Non-AS group (4.52±0.74 pmol/L vs.4.72±1.45pmol/L, P=0.007; 2.28±2.03μIU/mL vs.1.95±1.38μIU/mL, P=0.009). FT4, TT3 and TT4 had no difference between the two groups. 2) ABI was significantly positively associated with TT3(r=0.091, P=0.006) while baPWV was significantly negatively associated with TT3 and FT3(r=-0.065, P=0.049; r=-0.149, P<0.001). Multiple linear regression showed that FT3 were the negatively influencing factor of baPWV (β=-75.24, P<0.001). 3) baPWV was significantly higher in patients with subclinical hypothyroidism than without subclinical hypothyroidism (1831.11±347.39 cm/s vs.1729.32±377.12, P=0.027). 4) Logistic regression showed that FT3 was protective factor of AS assessed by baPWV (OR:0.708, 95% CI: 0.506-0.990, P=0.044).

Conclusions: T2DM patients with Arterial stiffness defined by ABI or baPWV have higher TSH and lower FT3 while baPWV was higher in patients with subclinical hypothyroidism. FT3 was negatively influencing factor of baPWV and protective factor of AS assessed by baPWV.


Y. Chen: None. Z. Hong: None. B. Ma: None. X. Wang: None. S. Qu: None.


National Natural Science Foundation of China (81970677)

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