Visual Abstract

The Aim: to identify key genes involved in angiogenic response and influenced by enhanced glycemic variability (GV) in diabetes.

Methods: Text-mining of Medline/Pubmed abstracts, reconstruction and analysis of gene networks related to GV and angiogenesis was performed by ANDSystem (www-bionet.sscc.ru/and/cell/). Genes associated with both hyperglycemia and hypoglycemia were attributed to be GV-related. Compounds targeting the identified genes were found using the TTD database (db.idrblab.net/ttd/).

Results: The set of genes implicated in angiogenesis that are up- or down-regulated by both hyperglycemia and hyperglycemia and compounds targeting and regulating these genes are summarized in the Table.

Conclusions: The obtained results support the hypothesis that detrimental effect of enhanced GV in diabetes could be realized by up- or down-regulation of the genes involved in angiogenic response. The role of the identified genes and compounds influencing their activity in the development of diabetic vascular complications requires experimental testing.

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Disclosure

O. V. Saik: None. V. Klimontov: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Sanofi, Research Support; Self; Boehringer Ingelheim International GmbH, Speaker’s Bureau; Self; AstraZeneca, Medtronic.

Funding

Russian Science Foundation (20-15-00057)

© 2021 by the American Diabetes Association
2021
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