Visual Abstract
Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes, but its pathogenesis has not been fully clarified. Schwann cells play an indispensable role in maintaining the structure and function of neurons, but the mechanism is complex. High fatty acid is the characteristic of diabetic complications. We used RSC96 to investigate the effects of palmitic acid on apoptosis and mitochondrial function. Our results showed increased ROS production and mitochondrial oxidative stress, increased apoptosis, and decreased ATP generation. DPN was aggravated by Schwann cell apoptosis, oxidative stress and mitochondrial dysfunction. Although the interaction between Schwann damage and neuronopathy remains to be elucidated, the present study may provide ideas for novel pathogenetic pathways of DPN.
J. Fan: None. L. Guo: Consultant; Self; AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., BD, Eli Lilly and Company, Merck & Co., Inc., Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk, Sanofi China.
