Retinal chronic inflammation plays a pivotal role in the development of diabetic retinopathy (DR). Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is associated with inflammatory and oxidative stress status. Some studies suggest that an elevated MHR can be a biomarker for diabetic complications. However, there are not adequate studies on MHR and DR. A total of 771 patients with T2DM and 607 healthy controls were included in this cross-sectional study. MHR and eye examination were checked. The predictive role of MHR on the development of DR in T2DM patients was analyzed. The MHR in patients with DR was significantly higher than that of both the non-DR diabetic patients (P < 0.05) and the healthy controls (P < 0.01). No significance were observed in the MHR of different DR severity grades. Moreover, MHR was similar between patients with non-macular edema and macular edema. Logistic regression analysis demonstrated that MHR was independently associated with the development of DR in diabetic patients [OR =1.377, 95% CI: 1.176-1.613, P < 0.01]. MHR can be an independent predictor of the development of DR in patients with T2DM.


Y. Tan: None. X. Tang: None. Y. Chen: None.

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