Visual Abstract

Type 1 diabetes (T1D) can lead to significant emotional distress and impaired quality of life (QoL). Hybrid closed-loop (HCL) technology seeks to relieve this burden, a goal with equal importance to improving glycemic outcomes. We evaluated change in QoL outcomes for adults (mean±SD, age 39±13y, T1D duration 19±12y, and baseline A1C 7.1±0.9%) before and after a 3-month outpatient study of HCL therapy with the Omnipod 5 System. Participants (N=115) completed validated assessment tools to capture various aspects of diabetes-related and generic QoL: the T1D Distress Survey (T1DDS), Hypoglycemic Confidence Scale (HCS), and World Health Organization Well-Being Index (WHO-5). Though QoL was relatively high at baseline across all 3 measures, we observed significant improvements in diabetes-related QoL with reduced T1DDS and increased HCS scores after 3 months of system use (Table). Among the T1DDS subscales, significant improvements were seen in powerlessness (change: ‑0.27), management distress (-0.18), hypoglycemia distress (-0.21), and eating distress (-0.24, all p<0.001). Generic QoL (WHO-5) was unchanged over the study period. In addition to glycemic efficacy and safety of the Omnipod 5 System (reported previously), these results reveal a significant improvement in QoL for adults with T1D and suggest features of the system may alleviate some of the burden associated with living with T1D.

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Disclosure

C. J. Levy: Advisory Panel; Self; Dexcom, Inc., Eli Lilly and Company, Employee; Spouse/Partner; AbbVie Inc., Other Relationship; Self; Dexcom, Inc., Research Support; Self; Abbott Diabetes, Dexcom, Inc., Insulet Corporation, Tandem Diabetes Care. W. H. Polonsky: Advisory Panel; Self; Intarcia Therapeutics, Inc., Consultant; Self; Abbott Diabetes, ADOCIA, Boehringer Ingelheim Pharmaceuticals, Inc., Dexcom, Inc., Insulet Corporation, Lilly Diabetes, Novo Nordisk, Onduo LLC., Sanofi US. K. K. Hood: Consultant; Self; Cecelia Health, Cercacor, LifeScan Diabetes Institute. S. A. Macleish: Advisory Panel; Self; Insulet Corporation. L. M. Huyett: Employee; Self; Insulet Corporation, Stock/Shareholder; Self; Insulet Corporation. T. Vienneau: Employee; Self; Insulet Corporation, Stock/Shareholder; Self; Insulet Corporation. T. T. Ly: Employee; Self; Insulet Corporation.

Funding

Insulet Corporation

© 2021 by the American Diabetes Association
2021
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