Background: Post-bariatric surgery weight regain is common and leads to recidivism of cardiometabolic diseases, including Type 2 Diabetes Mellitus (T2DM) . Endoscopic therapies are emerging tools to treat weight regain. This study aims to assess the effectiveness of endoscopic revision for post-bariatric surgery weight regain in people with T2DM.

Methods: A retrospective review was conducted on patients who underwent endoscopic revision for post-bariatric surgery weight regain from November 20to July 2021 at an academic center. The primary outcome was weight change at 1, 3, and 6 months post-endoscopic revision.

Results: The cohort (n=33) was mean age 55 years; 82% female; 45% non-Hispanic Black, 15% Hispanic; mean BMI 39.3; 63% with gastric bypass, 33% with sleeve gastrectomy, 3% with duodenal switch; 24% with T2DM at the time of revision. The mean time from bariatric surgery to revision was 12 years with mean 33% weight regain from post-surgery nadir. Patients with T2DM experienced similar mean percent weight loss as those without T2DM at 1 (5.34% vs. 4.93%) and 3 months (4.98% vs. 6.47%) post-revision but less weight loss at 6 months (-0.28% vs. 4.07%) (Figure 1) .

Conclusion: Endoscopic revision is an effective therapy for post-bariatric surgery weight regain. However, people with T2DM may experience less long term weight loss compared to those without T2DM, warranting further investigation.


S.Tejani: None. S.H.Dunn: None. A.Tavakkoli: None. S.E.Messiah: None. J.Almandoz: None.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at