Aims: The aim of this study was to study the relationship between the hypertriglyceridemic-waist (HTGW) phenotype and the risk of carotid artery atherosclerosis (CAA) in Chinese patients with type 2 diabetes.

Methods: A total of 2651 consecutive in-patients with type 2 diabetes (mean age 56±11 years, 58% women) were included. CAA was determined by Color Doppler Ultrasonography and defined by the formation of detectable carotid artery plaques. Logistic regression analysis was applied to relate HTGW phenotype to CAA.

Results: The prevalence of CAA was 46.3% and 26.2% respectively in patients with and without HTGW. Compared with participants who had no HTGW, those with the HTGW phenotype had higher levels of systolic blood pressure (139.2 mmHg vs. 132.7 mmHg, p < 0.05) , fasting plasma glucose (9.1 mmol/L vs. 8.5 mmol/L, p < 0.05) , HbA1c [73 mmol/mol (8.83%) vs. 63 mmol/mol (7.95%) , p < 0.05], apolipoprotein B (0.95 g/L vs. 0.89 g/L, p < 0.05) , C-reactive protein (8.23 mg/L vs. 4.92 mg/L, p < 0.05) , TNF-α (26.46 pg/ml vs. 16.80 pg/ml, p < 0.05) and mean intima-media thickness (0.85 mm vs. 0.79 mm, p < 0.05) , but lower levels of apolipoprotein A1 (1.21 g/L vs. 1.33 g/L, p < 0.05) . The hypertriglyceridemic-waist phenotype was associated with CAA (OR 1.55, 95% CI 1.07-2.24) , after adjusting for age, sex, duration of diabetes, body mass index, smoking, HbA1c, apolipoprotein B and C-reactive protein.

Conclusion: Among patients with type 2 diabetes, simultaneous measurement of waist circumference and triglycerides could be used as an inexpensive and simple approach to identify individuals with CAA.


L. Zhang: n/a. Y. Yang: None. J. Wang: None. Y. Dong: None.

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