25-LB: Peripheral Neuropathy and Associated Factors in Patients with Type 2 Diabetes Mellitus in Vietnam—A Cross-Sectional Study

Peripheral neuropathy and associated factors in patients with type 2 diabetes mellitus in Vietnam: A cross-sectional study Diabetes peripheral neuropathy (DPN) is the most common complication associated with diabetes mellitus. We aimed to establish the characteristic and associated factors of DPN in Vietnam. In total, 140 patients with type 2 diabetes mellitus (T2DM) were screened and enrolled consecutively over a six month period at the endocrinology department in 103 Military hospital. Questionnaires, demographic details, clinical examination, and blood tests were used to collect data from all patients. DPN was evaluated using diabetes neuropathy symptom score and nerve conduction study. Potential factors related to DPN were explored including body mass index, years with disease (<10 vs. ≥10 years) , glycemic control (HbA1C <7.5% vs. ≥ 7.5%) , glomerular filtration rate (GFR) , lipid profile. The prevalence of DPN was 43.5% (61/140) in the number of patients with T2DM. The main manifestation of peripheral nerve damage in subject is numbness 54,1%, decreased rough touch 52,56%. The majority of patients did not have movement disorders 95.08% and normal sense of deep sensation 93,4%. The percentage of patients with a burning sensation, reduction in raw tactile and movement disorders was higher in the group with duration of disease over 10 years (n=23) , compared to the group less than 10 years (n=38) (p <0.05) . The neurotransmitter index in the group of patients with HbA1C ≥ 7.5% (n=17) was significantly different compared to the group with HbA1C < 7.5% (n=44) (p < 0.05) . The group with GFR <70 ml/ph/1.73m² (n=12) showed the significant change in nerve conduction parameters compared to the group with GFR ≥ 70 ml/ph/1.73m² (n=49) (p < 0.05) . DPN is highly frequent among patients with T2DM in Vietnam. Associated factors to DPN included duration of disease, HbA1C level and GFR index. The good glycemic control and early clinical manifestation as well as evaluating the kidney function would play an important role in this problem.