The waist circumference-to-body-mass-ratio (W/BMI-Ratio) has attracted interest as a predictor of cardiovascular risk. Its power to predict cardiovascular events in patients with established coronary artery disease (CAD) is not known and is addressed in the present study. We prospectively recorded cardiovascular events in 1472 patients with angiographically verified coronary artery disease. The mean follow-up time was 6.3±3.2 years. At baseline, there the W/BMI-Ratio did not differ significantly between patients with T2DM and nondiabetic patients (3.5±0.4 vs. 3.6±0.3; p=0.234) . Prospectively, the W/BMI-Ratio significantly predicted the incidence of cardiovascular events (n=439) both univariately (standardized HR 1.36 [1.20-1.52]; p<0.001) and after adjustment for age, gender, smoking, LDL cholesterol, HDL cholesterol, hypertension and T2DM (standardized adjusted HR=1.12 [1.03-1.21], p=0.006) , whereas T2DM predicted cardiovascular events indepently from the W/BMI-Ratio (HR=1.34 [1.09-1.64], p=0.006) . We conclude that the W/BMI-Ratio and T2DM are mutually independent predictors of cardiovascular events in patients with established CAD.
A.Mader: None. L.Sprenger: None. A.Vonbank: None. B.Larcher: None. M.Maechler: None. A.Leiherer: None. A.Muendlein: None. H.Drexel: None. C.H.Saely: None.