Introduction: Breathe Well-being Diabetes Reversal Program (BDRP) provides personalized Lifestyle Management (LSM) including coaching on diet and exercise as needed by individuals with type 2 diabetes mellitus (T2DM) along with tracking their blood glucose levels, weight, and physical activity.
Objective: To evaluate the effectiveness of BDRP for achieving remission in individuals with T2DM in India.
Methodology: This observational study had three cohorts (1:1:1) who were treated with: (1) BDRP with doctor-prescribed medication, (2) BDRP with doctor-prescribed medication and personalized stress reduction module, and (3) Only doctor-prescribed medication (control group) . Program adherence level was categorized as high (H: >70%) , medium (M: ≥50%-<70%) , and low (L: <50%) ; H and M data of cohorts 1 and 2 are presented here. Program was provided for 4 months, and individuals followed up at 7, 10, 13, 16, and 19 months. Informed consent was obtained.
Results: The study included 181 individuals with an average age of 53.1 years, of which 1 (55.8%) were male. Overall, 46.7% (28) and 54.1% (33) individuals in cohorts 1 and 2 showed H and M adherence. Cohorts 1 and 2 showed 1.0% and 1.3% average HbA1c reduction vs. 0.3% with cohort 3 (overall population) after 4 months. At 4 months, in cohort 1, HbA1c levels <6.5% were observed in 32.1% individuals, which increased to 60.7%, 67.9%, and 78.6% at 7, 10, and 19 months vs. 36.4% individuals in cohort 2, which increased to 51.5%, 69.7%, and 81.8% at 7, 10, and 19 months, respectively. In cohorts 1 and 2, medication withdrawal was observed in 89.3% and 90.9% individuals at 13 months which was maintained up to 19 months.
Conclusion: BDRP was effective in achieving remission in individuals with T2DM in India. BDRP with personalized stress reduction module had better outcomes comparatively. Digital therapeutics could be a potential approach in achieving diabetes remission in Indian settings.
P.K.Goyal: None. S.K.Patra: Employee; Breathe Well-being. A.Kaicker: None. R.Verma: None. S.Goel: Employee; Breathe Well-being. S.Rehman: None. R.Jangid: None. V.Madhusudhana: None.