Objectives: To study the real-world effect of hybrid closed loop systems (HCLS) on glycemic control and quality of life (QoL) in pediatric patients with T1D.

Methods: Patients 2-20 years old with T1D for ≥ 1 year were recruited when starting t:slim x2 with CIQ (TS) or Omnipod 5 (O5). We collected time in range (TIR), time low (BG <70 mg/dl), A1c, and QoL survey responses at baseline and 3 months. Kruskal-Wallis rank sum test and chi-squared test were used for data analysis.

Results: Baseline data is in Figure 1. TIR improved by 7% after 3 months of HCLS use (p=0.004). Time low was unchanged after 3 months (p=0.3). Figure 2 shows results by subject.

Discussion: In this real-world study, HCLS improved TIR at 3 months without change in hypoglycemia. Data collection, enrollment, and analysis are ongoing with more results (A1c, QoL surveys) expected shortly.

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Disclosure

C.V. Tillotson: None. P.H. Nichols: None. K. Mofford: None. N. Leibel: None. R. Gandica: None.

Funding

National Institutes of Health (5T32DK065522-18)

© 2023 by the American Diabetes Association
2023
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