Introduction: Several reports showed that COVID-19 vaccine may cause type 1 diabetes (T1D), especially fulminant T1D (FT1D). This study investigates the incidence of T1D during 2007-2021 in a general population of China, where >90% of people have received a full COVID-19 vaccination (3 injections) in 2021.

Methods: A population-based registry of T1D was performed by the Beijing Municipal Health Commission Information Center.

Results: In this population included 14.14 million registered residents, we identified 7,697 people with newly diagnosed T1D from 2007 to 2021, including 4,094 men and 3,603 women. T1D incidence [95% CI] (/100,000 persons) increased from 2.77 [2.49, 3.08] in 2007 to 3.84 [3.53, 4.18] in 2021. From 2007 to 2019 the T1D incidence increased with an annual percentage change (APC) of 3.13% (p<0.05). However, the T1D incidence was stable from 2019 to 2021 (the APC was -11.5% (p>0.05)), indicating that T1D incidence did not increase when people were vaccinated in Jan-Dec 2021. Meanwhile, the T1D with diabetic ketosis/ketoacidosis as the initial presentation incidence increased from 2007 to 2019, and it was stable from 2019 to 2021 (P>0.05) (Figure 1). The incidence of FT1D did not increase from 2015 to 2021 (APC:8.9%, P=0.53).

Conclusion: Our study indicates that COVID-19 vaccination did not increase T1D onset, at least not on a large scale.


C.Liu: None. Z.Xin: None. J.Yang: None.


National Natural Science Foundation of China (81930019)

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