Introduction: According to the most recent International Diabetes Federation (IDF) atlas, there are 537 million persons worldwide who have diabetes. Indians had increased central adiposity and insulin resistance. Diabetes patients are more likely to develop Nonalcoholic Fatty Liver Disease (NAFLD) due to high insulin resistance. An increasingly sensitive indicator of insulin resistance is the TG/HDL ratio. Measuring liver stiffness helps diabetics predict progressive fibrosis. The current investigation uses fibro scans to evaluate the TG/HDL ratio and liver stiffness in diabetic patients.
Methods: After receiving consent, 181 newly diagnosed diabetics underwent fibro scans to measure their liver stiffness. Participants who had already had thiazolidinedione treatment or lipid-lowering therapy were disqualified from the study.
Results: The median stiffness ranged from 2.3 kpa to 34.8 kpa (8.0 kpa), and the median TG/HDL ratio ranged from 0.5 to 29.3 (4.5). The connection between the median stiffness and the TG/HDL ratio was 0.2. Further, 26.5% of participants (Liver stiffness measurement (LSM) > 9.1), 23.7% of subjects who were men, and 30% of subjects who were women, showed advanced fibrosis. Both men and women with LSM > 9.1 had high TG/HDL ratios, with a mean of 4.9 in the former group and 4.9 in the latter. These numbers were significantly higher than the TG/HDL cut-offs for predicting insulin resistance, which were 0.9 and 1.2 for females and males, respectively.
Conclusion: TG/HDL ratio and NAFLD have previously been linked utilising ultrasonography in nondiabetic persons. The more precise and sensitive method for NAFLD screening is the fibro scan. Liver fibrosis is predicted by median stiffness. In the index research, there is a high incidence of advanced fibrosis, which is associated with the TG/HDL
ratio. The TG/HDL ratio was high in all of the male and female individuals with advanced fibrosis.
A. Chandra: None. J. Dinkar: None. R. Ranjan: None.
