Abstract Purpose: To investigate the effects of ectopic fat on brain structure and cognitive function.

Methods: Data extraction and meta-analysis of eligible clinical studies were performed.

Results: The results showed ectopic fat was associated with the decreased total brain volume, posterior cingulate cortex volume, semioval center volume, sensorimotor cortex volume, and the increased lateral ventricle volume. Subcutaneous fat significantly was associated with the reduced risk of cerebral white matter hyperintensities (OR = 0.86, 95% CI: 0.74 to 1.00). Ectopic fat was associated with the decreased cognitive function. Visceral fat was significantly associated with poor cognitive outcomes (OR=1.42, 95% CI: 1.11 to 1.81).

Conclusion: Visceral ectopic fat was associated with the increased risk of brain structural changes and cognitive impairment. A new strategy identifying patients at risk of developing cognitive decline may be implemented timely and personalized treatment.

Fig.1 The relationship between ectopic fat and cognitive scores (WMD)

Disclosure

Z.Song: None. J.Liu: None. Z.Zhang: None. J.Zhou: None.

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