Background: Lifestyle intervention in achieving Type 2 diabetes (T2D) remission is gaining increasing significance. We aimed to identify predictors of diabetes remission after a one-year lifestyle intervention program in the Indian population.

Materials and methods: The current study enrolled 4948 patients with diagnosed T2D (>18 years) who underwent a lifestyle modification program at Freedom from Diabetes clinic between April & December 2021. The intervention included a customized vegan diet, exercise, stress management support, along with conventional medical management. Anthropometric and biochemical parameters were monitored with scheduled consultations every 3 months. Post-intervention remission was defined as HbA1c<48mmol/mol for a minimum of 3 months in the absence of pharmacotherapy. The primary outcome measure was predictors of diabetes remission based on regression analysis.

Results: Post-intervention, data on 2764 patients were available for analysis where 837 (30.2%) achieved remission. Remission was significantly associated with intermittent fasting (during intervention), initial medication status (OHA, external insulin, both or never started medicines), age at onset, absolute change in HbA1c & body weight, HOMA-IR (post-intervention), and duration of diabetes.

Conclusion: T2D remission can be achieved in nearly one-third of the patients through lifestyle intervention. Few baseline (age at onset, duration of diabetes, medication status) and few post-intervention parameters (decrease in weight and HbA1c, HOMA-IR) are independently associated with predicting T2D remission in this Indian population.


P.Tripathi: Board Member; Freedom from Diabetes Clinic. N.S.Kadam: Research Support; Freedom from Diabetes Clinic. A.R.Vyawahare: Research Support; Freedom From Diabetes. B.Sharma: Research Support; Freedom From Diabetes clinic. M.H.Ganla: Employee; Freedom from Diabetes Clinic. M.Das biswas: Employee; Freedom from Diabetes Clinic. B.D.Saboo: None.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at