Aim: To determine the relationship between depressive symptoms and insomnia with therapeutic non-adherence and metabolic control in patients with T2DM.

Methods: Observational, descriptive, cross-sectional study with analytical component. Adult patients with DM2 treated in an Endocrinology Service of a University Hospital of Asunción-Paraguay from May to October 2022. The Morinsky-Green adherence questionnaires, the Insomnia Severity Index (ISI), the Patient Health Questionnaire 9 (PHQ-9) and predetermined questionnaire for clinical characteristics where used.

Results: 171 patients were studied. Women: 69%. Mean age 54.9 ± 11.8 years. Symptoms of depression occurred in 61.9%. 59% suffered insomnia. The 64.3% of patients had moderate non-adherence. The mean HbA1c was 8.08 ± 0.16 %. Inadequate metabolic control (HbA1c >7%) was seen in 68% of patients. A relationship was found between depression and insomnia (p<0,001), in addition to the fact that the worse adherence the more depressive symptoms (p<0,001) and the more insomnia (p <0.001).Patients with poor metabolic control have more depressive symptoms (p=0,005) and insomnia (p=0,009).

Conclusion: Depressive symptoms were significantly related to non-adherence to treatment and to worse metabolic control, but not the presence of insomnia without depressive symptoms.

Disclosure

M.N.Escobar: None. A.I.Ramirez: None. E.D.Bueno colman: None. A.Benitez: None. M.Palacios: Speaker's Bureau; Sanofi. J.T.Jimenez: None.

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