Background: Glycemic variability (GV) has been associated with poor outcomes in critically ill patients. We aimed to study the association between GV and functional outcome (FO) in patients with acute ischemic stroke (AIS) using continuous glucose monitoring (CGM).
Method: Participants with AIS were enrolled and started blinded CGM (Dexcom G6) between Nov 2020 and Dec 2022. Glucose data from the first 72 hours after admission were analysed. Patients were classified into 3 groups based on change of FO (modified Rankin scale, MRS) at between admission and discharge. These included (i) remained independent (RI); (ii) deteriorated to dependent (DD); and (iii) remained dependent (RD).
Result: Sixty-seven patients (mean±SD age 72.1±13.7 years) were enrolled; 71.6% patients had no DM; 28.4% patients had DM. The median (IQR) NIHSS was 8 (3, 14), and 34.3% received reperfusion therapy. The percentage of patients with RI, DD, and RD was 25.4, 55.2, 19.4%. Patients with DD had older age, higher NIHSS at admission and at 24 hours after reperfusion therapy compared to those RI (Table). From CGM data, those with and without diabetes deteriorating to dependence had higher mean glucose and glucose SD than the group remaining independent at discharge.
Conclusion: Hyperglycemia and glucose SD are associated with deterioration of functional status at discharge after acute stroke.
L.Preechasuk: None. O.Halse: None. S.Banerjee: None. N.Oliver: Advisory Panel; Dexcom, Inc., Medtronic, Roche Diabetes Care, Research Support; Dexcom, Inc., Medtronic. N.E.Hill: Research Support; Dexcom, Inc. S.K.Rilstone: None. W.Tang: None. J.Man: None. M.Yang: None. E.Zhao: None. L.Hoque: None. E.Tuncay: None. P.Wilding: None.
