Introduction & Objective: With the increased use of continuous glucose monitoring (CGM), one of the core metrics of CGMs, time in range (TIR), is emerging as a key indicator in the clinical assessment of diabetes complications. This study investigated the relationship between the TIR assessed by CGM and diabetic kidney disease (DKD).

Methods: A total of 1,533 patients with type 2 diabetes were recruited. TIR was defined as the percentage of time spent within the glucose range of 3.9-10.0 mmol/L over a 24-h period. Type 2 diabetes patients with albuminuria ≥ 30 mg/24 h or an estimated glomerular filtration rate (eGFR) ≤ 60 ml/(min × 1.73 m2) were diagnosed with DKD.

Results: The overall prevalence of DKD was 29.7% in this study. TIR was inversely correlated with diabetes duration and HbA1c (P <0.001). Patients with DKD had significantly less TIR (P for trend <0.001) and the prevalence of DKD decreased with ascending TIR quartiles (P for trend <0.001). After adjusting for age, sex, BMI, diabetes duration, blood pressure, lipid profile, and HbA1c, patients in the highest TIR quartile were associated with a lower prevalence of DKD than those in the lowest TIR quartile (OR = 0.541 [95% CI, 0.362-0.810], P = 0.003).

Conclusion: This study reveals that TIR, a core metric assessed by CGM, is associated with DKD in type 2 diabetes.

Disclosure

S. Wang: None. J. Lu: None. W. Lu: None. W. Zhu: None. Y. Bao: None. J. Zhou: None.

© 2024 by the American Diabetes Association
2024
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