Introduction & Objectives: Menstruation can change the glycemia and insulin needs of individuals living with T1D. Hormonally-induced insulin resistance is thought to play a role in this process. This study evaluates if current treatment methods are associated with differences in CGM-recorded glycemia in relation to the timing of reported last menstrual periods (LMP).
Methods: Adolescent girls with T1D aged 10-18 years connected to a Midwestern Pediatric Diabetes Center Clarity account, were eligible for inclusion. A standard review of systems, which includes a reported LMP, is administered to all ambulatory patients across the organization. All patients reporting any LMP from 11/2018 - 8/2023 were included. CGM data was extracted from Dexcom Clarity and analyzed relative to the date of the LMP.
Results: During the study, 689 unique patients reported a total of 1892 menstrual cycles. Ambulatory Glucose Profile metrics were compared for the 7 days before and 7 days after the start of the self-reported LMP. There were no statistically significant differences in any of the CGM metrics (Table 1).
Conclusions: In this retrospective study, CGM metrics were not statistically or clinically different in the 7 days before to and the 7 days after a self-reported LMP. Prospective future studies are needed to evaluate the effects of advanced insulin delivery systems on glycemia in proximity to menstrual cycles.
R. McDonough: Speaker's Bureau; Provention Bio, Inc. A. Priebe: None. T. Hilyard: None. K. Dileepan: None. S. Tsai: Stock/Shareholder; Dexcom, Inc.
