1276-P: Insulin Resistance Is Associated with Salt Sensitivity and Endothelial Dysfunction

Aims: To evaluate in non-obese young normotensive salt sensitive (SS) or salt resistant (SR) offspring of hypertensive parents (_offSS-HT or _offSR-HT, respectively) 1) the possible association with insulin resistance and endothelial disfunction

Design and Methods: 41 _offSS-HT (29±2 years; 20 female), and 36 _offSR-HT (26±2 years; 16 female). Both groups were considered lean with a BMI 25kg/m2 and a waist circumference <98cm in males or <105cm in females. At baseline, creatinine clearance (CrCl), 24h urinary albumin excretion (UAE), glycemia and insulinemia, before and after 60 and 120 min a glucose overload (75 g) were measured. HOMA = fasting glucose (mg/dl × fasting insulin (μU/ml)/22.5 and the area under the curve of the Oral Glycemia Tolerance Test (OGTT) were calculated. Post ischemic minimun vascular resistance and forearm blood flow by pletismography was also assessed at baseline to determine endothelial function

Results: In _offSS-HT, UAE (53±3μg.min) and CrCl (124±6ml/min) were significantly higher than in _offSR-HT. (UAE: 12±4μg.min; p, 0.01 and CrCl 107±6ml.min; p, 0.01). An impaired vasodilatory post ischemic response was observed in _offSS-HT (1.8±0.3 AU) compared to _offSR-HT (2.8±0.6 AU; (p<0.01)At 60 min and 120-min, glycemia and insulinemia, post OGTT, were higher in _offSS-HT (140.1±18; 130±15mg.dl and 31.8±11; 31.8±11 IU, respectively) than in _offSR-HT (116.5±5: 6.5±3mg.dl and 18.8±7; 21.3±4IU, respectively; p<0.01).In a similar way, in SS-HT, glycemia AUC (258.80±25) and HOMA-IR (3.26±1.36 were greater compared to _offSR-HT(AUC: 194.39±6, p<0.0001; HOMA-IR: 1.52±0.27, p < 0.002).

Conclusions: Insulin resistance, endothelial disfunction and glomerular hyperfiltration was found in _offSS-HT suggesting a familiar aggregation and a higher cardio-reno-metabolic risk when compared with _offSR-HT.