The triglyceride-glucose (TyG) index has been linked to cardiovascular disease in diabetic or nondiabetic patients. However, it remains unclear whether elevated TyG index is associated with a high risk of cardiovascular disease in patients with type 1 diabetes. We enrolled 14,553 adults with type 1 diabetes with a mean follow-up of 7.52 years using the National Health Insurance Database in Korea between January 2009 and December 2015. We exclude patients who have other etiology of diabetes, cancer, and underlying cardiovascular disease. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] and categorized into four quartiles. The primary outcome is the hospitalization due to cardiovascular disease. Cox proportional hazards models were used to estimate adjusted hazard ratios. We found that the TyG index is positively associated with cardiovascular disease and all-cause mortality. Compared to Q1, the aHRs(95%CI) for the hospitalization due to cardiovascular disease of Q2, Q3, Q4 were 1.26(1.13-1.41), 1.38(1.24-1.54), 1.84(1.65-2.04). Furthermore, compared to Q1, the aHRs (95%Cl) for the all-cause mortality of Q2,3,4 were 1.19(1.05-1.35), 1.28(1.13-1.45),1.64(1.45-1.85).
In conclusion, elevated TyG index was associated with a higher risk of cardiovascular disease and all-cause mortality in patients with type 1 diabetes.
R. Oh: None. S. Cho: None. S. Kim: None. J. Kim: None. G. Kim: None. J. Kim: None.
