1298-P: Increased Fasting Glucagon-Like Peptide-1 Level Is Associated with Higher Triglyceride–Glucose Index in Type 2 Diabetes Mellitus Patients with Hypertriglyceridemia

Introduction & Objective: Triglyceride-glucose (TyG) index is a reliable and simple surrogate marker of insulin resistance (IR). Limited studies have been conducted to assess the association between fasting glucagon-like peptide-1 (fGLP-1) and IR estimated by TyG index. We aimed to investigate the association between fGLP-1 and TyG index in type 2 diabetes mellitus (T2DM) patients with hypertriglyceridemia and to further explore triglyceride or glucose, as parameters of TyG index, was more closely related to fGLP-1.

Methods: A total of 35 T2DM subjects and 27 subjects diagnosed with T2DM + hypertriglyceridemia were recruited. Hypertriglyceridemia was defined as serum triglyceride ≥ 1.7 mmol/L. Plasma total fGLP-1 concentrations was measured by enzyme-linked immunosorbent assay. The TyG index was determined as ln(fasting triglycerides [mg/dL]×fasting glucose [mg/dL]/2).

Results: Total fGLP-1 level was significantly increased in T2DM + hypertriglyceridemia subjects than T2DM subjects (29.44±12.21 pmol/L vs. 18.24±8.79 pmol/L, p=0.02). FGLP-1 level was positively correlated with TyG index (r=0.375, p=0.001) and fasting triglyceride (r=0.395, p=0.02). There was no significant association between fGLP-1 and fasting plasma glucose. Furthermore, linear regression analysis showed TyG index and triglyceride were independently associated with fGLP-1 (Β=0.328, p=0.02; Β=1.58, p=0.047, respectively).

Conclusion: In T2DM patients with hypertriglyceridemia, increased fGLP-1 was associated with higher IR as measured by TyG index. FGLP-1 was not related to glucose as a parameter of the TyG index, but fGLP-1 was significantly associated with fasting triglyceride. Increased fGLP-1 secretion may play a compensatory role in the pathogenesis of IR induced by hypertriglyceridemia.