Introduction & Objective: risk factors for liver fibrosis in metabolic associated steatotic liver disease are not clear in T2DM patients. We aimed to assess clinical, laboratory and body composition factors associated with liver stiffness in T2DM.
Methods: individuals >18 years attending the T2DM outpatient clinic were included in a cross-sectional study. Clinical, biochemical, anthropometric and body composition data were collected. Liver steatosis and stiffness were evaluated (ultrasound and elastography). Data were analyzed by x², t test and logistic regression.
Results: from 664 medical records reviewed, 204 met inclusion criteria and were included. So far, 87 patients were evaluated. Forty-one (47%) patients had mild, 13 (15%) moderate and 2 (2%) severe liver steatosis. In elastography, 54 (65%) patients had no liver stiffness (≤5 kPa), while 28 had some degree (5 - 9 kPa n = 19; >9 kPa n = 9). Variables associated with liver stiffness are depicted in Table 1. In multivariate analysis, ALT and BMI remained associated with higher liver stiffness. Similar results were observed when BMI was switched for total fat mass, trunk fat or limbs fat mass. NFS was the only score associated with liver stiffness.
Conclusion: ALT and parameters of fat mass were independently associated with higher liver stiffness. Notably, NFS performed better than FIB-4 score. Global fat mass, rather than fat in a specific body segment, is associated with higher risk for liver stiffness.
G.T.C. Pulz: None. P. de Almeida: None. G.R. Muller: None. M.K. Jung: None. V. Copatti: None. M.G. Friedrich: None. C.S. Faccin: None. R.S. De Fraga: None. C.B. Leitao: None.
