1366-P: Cardiovascular Complications (Myocardial Infarction, Stroke, and End-Stage Renal Disease) and Mortality in Youth-Onset Type 1 and Type 2 Diabetes Based on National Health Insurance Service (NHIS) Data

Background: In South Korea, little is known regarding the mortality and the occurrence of related cardiovascular complications in youth-onset diabetes.

Methods: Based on Korean National Health Insurance Service-National Sample Cohort database from 2006 to 2020, data of patients with type 1 (T1DM) and type 2 diabetes (T2DM) who were aged ≤30 were collected. Mortality and incidence of cardiovascular complications (myocardial infarction [MI], stroke and end-stage renal disease [ESRD]) in T1DM and T2DM were compared to the general population of the cohort.

Results: The total population was 513,633. Patients with T1DM and T2DM were 413 and 1,250, respectively. After adjusting for sex, age and income, the odds ratios (ORs) of MI were 8.71 (95% confidence interval [CI], 3.25-23.31) for T1DM and 7.81 (95% CI, 4.38-13.94) for T2DM. The ORs of stroke were 5.95 (95% CI, 2.23-15.91) for T1DM and 4.72 (95% CI, 2.59-8.60) for T2DM. The ORs of ESRD were 144.05 (95% CI, 89.00-233.15) for T1DM and 28.20 (95% CI, 15.69-50.66) for T2DM. The mortality risks in patients with T1DM (5.16; 95% CI, 2.77-9.61) and T2DM (5.18; 95% CI, 3.65-7.36 for T2DM) were significantly higher than the control group. The morality risk for T2DM aged < 20 (14.00; 95% CI, 5.82-33.69) was predominantly higher than other subgroups in T1DM and T2DM.

Conclusion: In South Korea, patients with youth-onset diabetes had a high risk of cardiovascular complications, particularly more pronounced in patients with T1DM for ESRD. Both types of diabetes were associated with notably increased mortality risk compare to the general population.