1375-P: Study of Clinical Profile and Comparison of Metabolic Parameter and Vitamin D Level in Patients with Young-Onset Diabetes Mellitus

Introduction: Metabolic phenotype of Indian population differs markedly from western population. Vitamin D deficiency has been associated with morbidities related to cardiovascular, inflammatory, autoimmune diseases and malignancy. Recent studies have linked vitamin D to the pathogenesis of diabetes and its complications.Objectives: To study the clinical profile and to correlate the metabolic parameters and Vitamin-D level among young onset diabetes patients.

Methodology: Total 148 Patients with young onset diabetes mellitus, presenting to the opd of Endocrinology department between July 2021 to August 2023 were included. Relevant sociodsemographic, metabolic and anthropometric parameters were obtained.

Results: Majority of patients were T1DM(64.2%), followed by T2DM(16.5%), FCPD(13.8%), MODY(2.8%) and Unclassified(2.7%.). Mean age was 15.6±8.9 years. Mean BMI was 17.27±5.1. BMI has significant(p<0.05) positive correlation with serum TG. Overall dyslipidaemia observed in 10.1% of patients. HbA1C level has significantly(p<0.05) negative correlation with TC and significant positive correlation with TG and significant(p<0.05) negative correlation with Vit-D level. Vit-D level was low in 48% of patients.

Conclusion: HbA1C was found to have negative correlation with Vitamin-D level and positive correlation with TG level among young diabetic patients. About one in two patients had low Vitamin-D level. We may conclude that Vit-D level and TG level may play important role in young onset diabetes mellites. However, further research is mandated to establish any significant association.