1388-P: Risk of Diabetes among Children and Young Adults after COVID-19 Infection—The DiCAYA Study

Introduction & Objective: The association between COVID-19 infection and incident diabetes remains unclear despite recent research. Using a multistate electronic health record-based surveillance approach, we examined the risk of new diabetes among children (<18) and young adults (18-44) post COVID-19 infection.

Methods: Pooled fixed-effects meta-analyses were performed. Patients (n=5,412,604) with no evidence of diabetes who received care in 2018-2019 were followed through diabetes diagnosis, death, or end of follow-up (12/31/22). COVID-19 infection was defined using labs or diagnoses from 6/1/20-12/31/21. Person-time was calculated from infection date for cases or a randomly selected visit date for controls. Propensity score-weighted Cox regression models were run at each site individually to estimate hazard ratios (HR) for diabetes risk for children and young adults.

Results: COVID-exposed individuals were at higher risk of incident diabetes compared to those with no documented infection (Children HR = 1.85 [1.69, 2.03]; Young Adult HR = 1.37 [1.31, 1.42]). All participating sites reported elevated risk but results were more heterogeneous across young adults (range 1.3-3.7, heterogeneity I2=94% vs. range 1.6-2.0, I2=0%, Figure 1).

Conclusion: These preliminary findings suggest COVID-19 infection is associated with increased risk of incident diabetes among children and young adults.

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