Introduction & Objective: Left ventricular hypertrophy (LVH) is a common complication associated with higher cardiovascular risk in Type 2 diabetes mellitus (T2DM) patients. Although many abdominal obesity indices (AOIs) have been established, studies investigating their associations with LVH in T2DM are limited. This study aimed to investigate the relationship between AOIs and LVH in T2DM.
Methods: A cross-sectional study involving 5,105 T2DM patients without prior cardiovascular disease was conducted in Beijing, China. LVH was assessed using echocardiography. Metabolic Score for Visceral Fat (Mets-VF), Waist Circumference (WC), Hip Circumference (HC), Visceral adipose tissue (VAT), BMI, Waist-to-Hip Ratio (WHR), Waist-to-Height Ratio (WHtR), Body Roundness Index (BRI), Abdominal Volume Index (AVI), Conicity Index (CI), Lipid Accumulation Product (LAP), Cardiometabolic Index (CMI), Visceral Adiposity Index (VAI), and Chinese Visceral Adiposity Index (CVAI) were investigated. Multivariate logistic regression and restricted cubic spline regression models were used to evaluate associations and potential nonlinear relationships between AOIs and LVH risk.
Results: Among 5,105 participants (aged 49.8 ± 12.2 years), 560 (10.9%) had LVH. After adjusting for confounding factors, METS-VF showed the strongest association with LVH (OR 9.78; 95% CI 6.15-15.75, p value <0.001). WC, HC, VAT, BMI, WHR, WHtR, BRI, LAP, CMI, and CVAI also maintained significant associations with LVH (ORs 1.003 to 1.916, p value <0.05). Linear associations were observed for METS-VF, WC, VAT, BMI, and WHtR, while nonlinear associations were found for HC, WHR, BRI, LAP, CMI and CVA. AVI, CI, and VAI showed no independent significant association with LVH.
Conclusions: METS-VF outperforms other well-established AOIs in predicting LVH, highlighting its potential as a valuable tool for assessing cardiovascular risk in T2DM patients.
L. Wang: None. D. Wang: None. Y. Wang: None. L. Wei: None. L. Yang: None.
