1797-LB: Detection of Potential Therapeutic Target Associated with Coronary Artery Disease in Type 2 Diabetes Patients—System Biology Approach Free

Introduction & Objective: Type 2 diabetes (T2D) and coronary artery disease (CAD), co-morbidity of which presents mortality risk, are both systemic diseases linked with altered immune response. Treatments for the co-morbid condition of T2D and CAD are not yet developed to a satisfactory level, because of lack in the understanding the linkage between them. We aim to investigate the genes that are co-expressed in T2D and CAD in order to gain a better understanding of the common causal relationship between these diseases, and to identify potential biomarkers and targets for the treatment of T2D and CAD.

Methods: We identified differentially expressed genes (DEGs) that are co-expressed in T2D and CAD genes from CAD and T2DM patients. We performed pathways analysis to predict the commonalities between the signaling pathways and molecular networks attributed to these two diseases.

Results: We identified 451 DEGs in T2D and 644 DEGs in CAD patients compared with healthy controls. Of these DEGs, 32 were shared between the two comparisons. These common DEGs significantly mapped to shared pathways. Such shared pathways can be considered as partly accounting the associations between these two disorders. Of the common DEGs, TLR4, IGF1, UBB, MAPK1, CCND1, MYC, JUN and MMP9 are key genes of the molecular network with acceptable diagnostic power in T2DM and CAD datasets. We further predicted the miRNAs and transcription factors for these key genes.

Conclusion: Our study identified key genes that might play critical roles in both T2D and CAD. These findings may lead new understanding of the associations between CAD and T2D and facilitate novel treatment or prevention strategies. However, further experimental validations and clinical trials need to be pursued to verify our results.