Objectives: We aimed to assess correlation between baPWV and ABI, specifically role of baPWV in participants with normal ABI for major adverse limb events (MALE) and mortality in people with diabetes and first diabetic foot ulcer (DFU).

Research Design and Methods: A total of 16000 patients with type 2 diabetes were screened and 2186 individuals followed until 31st December 2022 or the time of death, whichever occurred earlier. A detailed demographic and diabetes complications were recorded. Whole cohort was divided into three groups based on the presenting ABI: group A: ABI 0.7-0.9, group B-ABI: 0.9-1.2 and Group C:ABI>1.2. Presenting baPWV was divided into quartiles as <1642cm/sec, 1642-1896cm/sec,1897-2210 cm/sec and >2210cm/sec for all individuals.. A stepwise logistic regression was used to determine the most relevant predictors of MALE and all-cause mortality.

Results: Median age of participants was 61(53-67) years, duration of diabetes 10(6-15)years and follow up duration of 6(2-8) years. In comparison with participants having a baPWV<1642 cm/sec, the odds for mortality was significantly higher in individuals with baPWV >2210 cm/sec [OR 1.745(1.315-2.315); p<0.001]. At baPWV 1678 cm/sec, sensitivity was 68% and specificity of 62% for predicting mortality. On multivariate logistic regression predictors of mortality were- Age>57.5 years [OR 1.285(1.007-1.639), p-0.004], eGFR<71.5 ml/min/1.73 m2 [OR 1.434(1.128-1.824); p -0.003], any amputation [OR 1.290(1.002-1.660), p-0.049] and bAPWV >2210cm/sec [OR 1.603(1.160-2.214); p<0.001].

Conclusion: High baPWV is a significant predictor of mortality in people with diabetes presenting with a DFU despite a normal ABI.

Disclosure

A. Gupta: None. A. Rastogi: None.

© 2024 by the American Diabetes Association
2024
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