184-OR: Association between Composite Dietary Antioxidant Index and Stroke among U.S. Adults with Diabetes—Insights from NHANES

Introduction & Objective: While previous research suggests a negative correlation between the Composite Dietary Antioxidant Index (CDAI) and stroke prevalence, particularly in pre-diabetes, data on this relationship in diabetic individuals remain limited. This study aims to assess the association between CDAI and stroke risk in individuals with diabetes.

Methods: This cross-sectional study analyzed data from the NHANES from 2003 to 2018, including 6735 participants aged ≥20 with diabetes. Stroke status was determined based on self-report. The CDAI was calculated using dietary intake data of six antioxidants (vitamins A, C, E, carotenoids, selenium, zinc) obtained from 24-hour dietary recall interviews. The association between CDAI and stroke risk was assessed using multivariate logistic regression and restricted cubic spline analysis.

Results: The mean age of participants was 59.6 ± 13.6 years, 51.5% were male, with 611 (9.1%) reporting a stroke. Higher CDAI levels were associated with a lower risk of stroke after adjusting confounding factors (OR = 0.96; 95% CI 0.92-0.99, P<0.001). Specifically, participants in the highest CDAI quintile had a 43% lower stroke prevalence compared to those in the lowest quintile (OR = 0.57, 95%CI 0.40-0.83, P = 0.003). Restricted cubic spline showed that there was a negative linear association between CDAI and stroke.

Conclusion: This study found a negative relationship between CDAI and stroke risk in US diabetic adults, highlighting the potential role of antioxidant-rich diets in stroke prevention.