Aim: To compare glycaemic control in adolescents with Type 1 Diabetes (T1D) on Minimed 780G system with simplified meal announcement (fix) versus precise carbohydrate counting (flex) over an extended period of 18 months.

Methods: Adolescents with T1D were randomly distributed in a 1:1 ratio to utilize the MiniMed 780G system in conjunction with either the “flex” or “fix” meal announcement methods. Participants were followed for 18 months with data analysis at 3, 6, 12 and 18 months. The primary endpoint was the difference in time-in-range (TIR), and secondary endpoints included glycated hemoglobin (HbA1c) and other glucose and insulin metrics.

Results: At 18 months, TIR (70-180 mg/dL) was significantly higher in the flex versus fix group (80.9% versus 73.2%, respectively; p=0.001). There was no significant difference in HbA1c between the fix (6.9±0.6%) and flex groups (6.6±0.7%) at 18 months (p=0162). Glucose target of 100mg/dl, active insulin time of 2 hours and rule of 360 for carb ratio were used in >90% of participants in both groups.

Conclusion: Using the MiniMed 780G system with a simplified meal announcement, adolescents can achieve and maintain the international targets of glycaemic control over an extended period (18 months); however, carbohydrate counting resulted in superior TIR.

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Disclosure

G. Petrovski: None. J. Campbell: None. K. Hussain: None.

© 2024 by the American Diabetes Association
2024
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