Introduction & Objective: The triglyceride-glucose (TyG) index, an effective marker of insulin resistance (IR), has been confirmed to be associated with the risk of cardiovascular events in T2DM patients. However, studies related to the correlation between TyG index and diabetic kidney disease (DKD) is still limited.
Methods: 678 T2DM patients were selected from Metabolic Management Center of the First Affiliated Hospital of Dalian Medical University from October 2016 to October 2022. The patients were divided into groups according to the different change trajectories of TyG index, eGFR, and urinary albumin according to latent class growth model (Figure A-C), and multiple unordered logistic regression was used to analyze the correlation between TyG trajectory, eGFR trajectory and urinary albumin trajectory.
Results: Compared with the middle stable trajectory group of eGFR, the TyG index of patients in the low decline trajectory group and the high stable trajectory group was higher (P<0.001). Compared with the low trajectory group of urinary albumin, the TyG index of patients in the middle trajectory group and high trajectory group was higher (P<0.05). Trajectories of TyG index in T2DM patients were related to trajectories of eGFR and urinary albumin (Table 1).
Conclusion: TyG index is related to DKD in T2DM patients.
S. Yu: None. L. Men: None. J. Du: None.
