Introduction: Patients with early-onset type 2 diabetes (EOD) have 1.6-fold increased risk of cardiovascular death. Our study intends to screen for early cardiovascular abnormalities in EOD patients, and distinguish the population with cardiovascular risk through cluster classification.

Method: A total of 400 newly diagnosed EOD patients come from the Early onset diabetes Prospective multicenter study from Mar.2021 to Nov.2023. Echocardiography and carotid ultrasound were performed within 3 months after diagnosis. K-means was used for cluster classification based on age, BMI, HbA1c, HOMA2-β, HOMA2-IR, and GAD antibodies.

Result: Patients with left atrial/ventricular enlargement had higher BMI (32.78±5.58 vs. 28.92±5.10 kg/m2, p<0.001), C-peptide (3.86[3.02,4.76] vs. 3.05[2.23,4.07] ng/ml, p<0.001), and fasting insulin level (19.85[15.11,33.29] vs. 14.23[9.03,23.29] uU/ml, p<0.001). After adjusting for gender and BMI, patients with higher fasting insulin levels had an increased risk of left atrial/ventricular enlargement (OR=2.238, 95% CI: 1.179-4.250).

Conclusion: A higher proportion of EOD patients were diagnosed with cardiovascular abnormalities, especially those with obesity and insulin resistance (MOD and SIRD subtype). Cluster classification can help accurately distinguish patients at higher risk of cardiovascular complications.

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Disclosure

H. Lian: None. Q. Ren: None. W. Liu: None. R. Zhang: None. X. Zou: None. X. Han: None. L. Ji: None.

Funding

Beijing Science and Technology Committee Fund (Z201100005520012)

© 2024 by the American Diabetes Association
2024
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