It has been established that the triglyceride glucose (TyG) index is a reliable indicator of insulin resistance (IR), which strongly impact to development of hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). However, the relation between NAFLD and the TyG index remains not fully understood. We examined and analyzed the association between NAFLD and the TyG index in a population of healthy adults in Korea.

A total of 5158 participants who visit health promotion center, underwent blood sampling and abdominal ultrasonography were analyzed in this study. Degree of hepatic steatosis and NAFLD was classified via ultrasonograpic findings.

According to changes in the TyG index, significant changes in metabolic parameters were observed. The prevalence of NAFLD also increased proportionally with the increase in the TyG index. We also performed additional exploration using HOMA-IR with logistic regression analysis. The TyG index showed more strong predictive power for prevalence of NAFLD than HOMA-IR. Comparing the lowest and highest quartiles of the TyG index and HOMA-IR, the odds ratio for NAFLD prevalence in the TyG index was 3.11 (95% CI: 2.46-3.93; P for trend <0.01), which is higher than the value of 1.82 in HOMA-IR (95% CI: 1.35-2.45; P for trend <0.01).

As a result of our study, prevalence of NAFLD showed strong association with the TyG index. Additionally, the TyG Index showed stronger predictive value for NAFLD compared to HOMA-IR.

Disclosure

S. Lee: None.

© 2024 by the American Diabetes Association
2024
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