978-P: Impact of Hybrid Closed-Loop System on Glycemic Control and Quality of Life among Japanese Individuals with Type 1 Diabetes

Introduction & Objective: The effectiveness of the hybrid closed-loop (HCL) system in managing type 1 diabetes (T1D) has been reported. While insulin pump therapy has also been shown to improve quality of life (QOL) more than multiple daily insulin injections, the integration of HCL functionality is anticipated to further improve QOL. This study investigated the changes in continuous glucose monitoring (CGM) metrics and QOL during 6-month treatment with the automode function of the HCL system in individuals with T1D.

Methods: In this single-center, single-arm, retrospective observational study, 35 Japanese individuals with T1D (9 men, mean age 46 ± 13 years) were evaluated over the 6 months of treatment with automode use of Minimed 770G pump (Medtronic Japan K.K.). CGM metrics including time in range (TIR), time below range (TBR), time above range (TAR), and coefficient of variation (CV) were measured at baseline, 1, 3, and 6 months. QOL was assessed using 4 questionnaires (PAID, DTSQ, ITR-QOL, and SF36) at baseline, 3, and 6months. Mixed-model repeated measures (MMRM) analysis was conducted for time-series data comparison.

Results: HbA1c levels remained stable, with the mean levels of 7.4 ± 0.7% (mean ± SD) at both baseline and after 6 months of automode use. TIR significantly increased from 65.3 ± 12.5% at baseline to 70.6 ± 8.7% at 6 months (p = 0.0001), while TBR and TAR significantly decreased (p = 0.019, and 0.007, respectively). CV also significantly decreased at 6 months (p = 0.0022).Significant improvement was observed in ITR-QOL from baseline to 3 months (p = 0.0001) and maintained at 6 months (p = 0.0191).

Conclusion: This study observed favorable changes in CGM metrics, with an increase in TIR and decreases in TBR, TAR and CV, as well as improvement in ITR-QOL among Japanese individuals with T1D patients after 6 months of automode use in the HCL system.