Each month, the Diabetes editorial team chooses a single paper to be designated the Paper of the Month, which is then made available for free online and added to an exclusive collection (https://diabetesjournals.org/collection/1619/Diabetes-Paper-of-the-Month). Congratulations to the 2024 winners!

David A. D ’Alessio, MD

Editor in Chief, Diabetes

Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis 

Dongdong Wang, Maria Joy Therese Jabile, Junfeng Lu, Logan K. Townsend, Celina M. Valvano, Jaya Gautam, Battsetseg Batchuluun, Evangelia E. Tsakiridis, James S.V. Lally, and Gregory R. Steinberg

https://doi.org/10.2337/db23-0495

Adipocyte Glucocorticoid Receptor Activation With High Glucocorticoid Doses Impairs Healthy Adipose Tissue Expansion by Repressing Angiogenesis 

Anna Vali, Héloïse Dalle, Alya Loubaresse, Jérôme Gilleron, Emmanuelle Havis, Marie Garcia, Carine Beaupère, Clémentine Denis, Natacha Roblot, Karine Poussin, Tatiana Ledent, Benjamin Bouillet, Mireille Cormont, Jean-François Tanti, Jacqueline Capeau, Camille Vatier, Bruno Fève, Alexandra Grosfeld, and Marthe Moldes

https://doi.org/10.2337/db23-0165

High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans 

Sarah M. Gray, Elisha Goonatilleke, Michelle A. Emrick, Jessica O. Becker, Andrew N. Hoofnagle, Darko Stefanovski, Wentao He, Guofang Zhang, Jenny Tong, Jonathan Campbell, and David A. D’Alessio

https://doi.org/10.2337/db23-0201

None selected

Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice

Devi Kasinathan, Zheng Guo, Dylan C. Sarver, G. William Wong, Shumei Yun, Aaron W. Michels, Liping Yu, Chandan Sona, Matthew N. Poy, Maria L. Golson, and Dax Fu

https://doi.org/10.2337/db23-0568

Gut Microbiota−Tryptophan Metabolism−GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin 

Yafei Jiang, Jin Yang, Li Xia, Tianjiao Wei, Xiaona Cui, Dandan Wang, Zirun Jin, Xiafang Lin, Fei Li, Kun Yang, Shan Lang, Ye Liu, Jing Hang, Zhe Zhang, Tianpei Hong, and Rui Wei

https://doi.org/10.2337/db23-0553

Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity

Jordan J. Wright, Adel Eskaros, Annika Windon, Rita Bottino, Regina Jenkins, Amber M. Bradley, Radhika Aramandla, Sharon Philips, Hakmook Kang, Diane C. Saunders, Marcela Brissova, and Alvin C. Powers

https://doi.org/10.2337/db23-0009

Glucose Transporters Are Key Components of the Human Glucostat

Inbal Caspi, Daniel M. Tremmel, Julian Pulecio, Dapeng Yang, Dingyu Liu, Jielin Yan, Jon S. Odorico, and Danwei Huangfu

https://doi.org/10.2337/db23-0508

Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia 

Alessandro Bonifazi, Michael Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O. Mantilla-Rivas, Comfort A. Boateng, Amy J. Eshleman, Aaron Janowsky, Margaret K. Hahn, Gary J. Schwartz, Barbara S. Slusher, Amy Hauck Newman, and Zachary Freyberg

https://doi.org/10.2337/db24-0175

A 3-Week Ketogenic Diet Increases Skeletal Muscle Insulin Sensitivity in Individuals With Obesity: A Randomized Controlled Crossover Trial 

Thien Vinh Luong, Mette Glavind Bülow Pedersen, Caroline Bruun Abild, Katrine Meyer Lauritsen, Mette Louise Gram Kjærulff, Niels Møller, Lars Christian Gormsen, and Esben Søndergaard

https://doi.org/10.2337/db24-0162

Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy 

Qian Yang, Marina Yasvoina, Abraham Olvera-Barrios, Joel Mendes, Meidong Zhu, Cathy Egan, Adnan Tufail, and Marcus Fruttiger

https://doi.org/10.2337/db24-0107

Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

Max C. Petersen, Mihoko Yoshino, Gordon I. Smith, Rafael C. Gaspar, Mario Kahn, Dmitri Samovski, Gerald I. Shulman, and Samuel Klein

https://doi.org/10.2337/db24-0083

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