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Issues
July 2025
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Cover Image
Cover Image
On the cover: The Rehearsal Studio, oil on canvas, 2025, Maren R. Laughlin, artist, in collaboration with Gisele Sonnier. For more information, see The Art of Diabetes Care in the July issue of Diabetes Care, available online at
diabetesjournals.org/care/issue/48/7 . - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0012-1797
EISSN 1939-327X
In this Issue
Diabetes Spotlight
Diabetes Spotlight: Carmella Evans-Molina, MD, PhD—Charting β-Cell Dysfunction to Delay the Onset of Type 1 Diabetes
Diabetes June 2025, Vol.74, 1035-1036. doi:https://doi.org/10.2337/dbi25-0030
Perspectives in Diabetes
What Is Gestational Diabetes—Really?
Diabetes April 2025, Vol.74, 1037-1046. doi:https://doi.org/10.2337/dbi24-0041
Commentary
Special Collection: NIDDK 75th Anniversary
NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Longevity
Diabetes April 2025, Vol.74, 1050-1052. doi:https://doi.org/10.2337/dbi25-0019
NIDDK: Celebrating 75 Years of Advancing Diabetes Research
Diabetes April 2025, Vol.74, 1053-1056. doi:https://doi.org/10.2337/dbi25-0023
Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative
Audrey V. Parent; Ashutosh Agarwal; Juan Rene Alvarez-Dominguez; Rafael Arrojo e Drigo; Mark A. Atkinson; Michael A. Brehm; Leonardo M.R. Ferreira; Klaus H. Kaestner; Vira Kravets; Joyce C. Niland; Denis O’Meally; Layla Rouse; Holger A. Russ; Cherie L. Stabler; John S. Kaddis
Diabetes April 2025, Vol.74, 1057-1067. doi:https://doi.org/10.2337/db25-0097
Advances in Cell Replacement Therapies for Diabetes
Bernhard J. Hering; Michael R. Rickels; Melena D. Bellin; Jeffrey R. Millman; Alice A. Tomei; Andrés J. García; Haval Shirwan; Cherie L. Stabler; Minglin Ma; Peng Yi; Xunrong Luo; Qizhi Tang; Sabarinathan Ramachandran; Jose Oberholzer; Camillo Ricordi; Timothy J. Kieffer; A.M. James Shapiro
Diabetes April 2025, Vol.74, 1068-1077. doi:https://doi.org/10.2337/db25-0037
The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes
Teresa L.Z. Jones; Irina Kusmartseva; Silvio Litovsky; Rahul Thakar; Amanda L. Posgai; Robert H. Eckel; Mark A. Atkinson
Diabetes April 2025, Vol.74, 1078-1088. doi:https://doi.org/10.2337/db25-0017
Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data
Maria C. Costanzo; Beena Akolkar; Melina Claussnitzer; Jose C. Florez; Anna L. Gloyn; Struan F.A. Grant; Klaus H. Kaestner; Alisa K. Manning; Karen L. Mohlke; Stephen C.J. Parker; Paul M. Titchenell; Miriam S. Udler; Melissa A. Jones; Tania N. Kamphaus; Rachel A. Fischer; Mark I. McCarthy; Melissa R. Miller; Michael Boehnke; AMP T2D Consortium; AMP CMD Consortium; Jason Flannick; Noël P. Burtt
Diabetes April 2025, Vol.74, 1089-1098. doi:https://doi.org/10.2337/db25-0042
Celebrating the Past, Present, and Future of NIDDK-Supported Research Centers Focused on Diabetes, Endocrinology, and Metabolic Diseases
Corinne M. Silva; Pamela L. Thornton; Shavon Artis Dickerson; Thomas L. Eggerman; Maren R. Laughlin; Julie A. Wallace; Mary C. Hanlon-Tilghman; William T. Cefalu
Diabetes April 2025, Vol.74, 1099-1106. doi:https://doi.org/10.2337/db25-0039
Metabolism
DA-1241, a GPR119 Agonist, Ameliorates Fatty Liver Through the Upregulation of TFEB-Mediated Autophagy
Diabetes March 2025, Vol.74, 1107-1120. doi:https://doi.org/10.2337/db24-0370
Analysis of Multiple Insulin Actions in Single Muscle Fibers From Insulin-Resistant Mice Reveals Selective Defect in Endogenous GLUT4 Translocation
Sebastian Judge; Stewart W.C. Masson; Søren Madsen; Meg Potter; David E. James; James G. Burchfield; Alexis Diaz-Vegas
Diabetes April 2025, Vol.74, 1121-1134. doi:https://doi.org/10.2337/db25-0022
Obesity Studies
Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis
Hiro Kohda; Miyako Tanaka; Shigeyuki Shichino; Satoko Arakawa; Tadasuke Komori; Ayaka Ito; Eri Wada; Kozue Ochi; Xunmei Yuan; Takehiko Takeda; Atsuhito Saiki; Ichiro Tatsuno; Kenji Ikeda; Yuki Miyai; Atsushi Enomoto; Yoshihiro Morikawa; Shigeomi Shimizu; Satoshi Ueha; Kouji Matsushima; Yoshihiro Ogawa; Takayoshi Suganami
Diabetes March 2025, Vol.74, 1135-1152. doi:https://doi.org/10.2337/db24-0762
BAP1 Suppresses White Adipose Tissue Browning and Thermogenesis Through Deubiquitinating KDM1B
Pengchao Wang; Jingbo Zhu; Liuye Yang; Yilong Wang; Minglu Liang; Fengcen Li; Ze Wang; Kaiyuan Liu; Mingfa Ai; Dazhu Li; Kai Huang; Meng Du
Diabetes April 2025, Vol.74, 1153-1167. doi:https://doi.org/10.2337/db24-1011
Identifying Four Obesity Axes Through Integrative Multiomics and Imaging Analysis
Chiemela S. Odoemelam; Afreen Naz; Marjola Thanaj; Elena P. Sorokin; Brandon Whitcher; Naveed Sattar; Jimmy D. Bell; E. Louise Thomas; Madeleine Cule; Hanieh Yaghootkar
Diabetes April 2025, Vol.74, 1168-1183. doi:https://doi.org/10.2337/db24-1103
Islet Studies
Surface Modification of Islets With L-DOPA–KF7 Enhances Islet Survival by Inhibiting IBMIR in Intrahepatic Islet Transplantation
Daopeng Yang; Bin Qiao; Fang Bai; Jinliang Duan; Haibin Ji; Xue Ma; Zepeng Lin; Yibo Hou; Xiaoshun He; Xiaofeng Zhu; Bowen Zhuang; Xiaoyan Xie; Anbin Hu
Diabetes April 2025, Vol.74, 1184-1195. doi:https://doi.org/10.2337/db24-1033
Pathophysiology
The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Heba M. Ismail; David Cuthbertson; Alfonso Galderisi; Ingrid Libman; Laura Jacobsen; Antoinette Moran; Alessandra Petrelli; Mark Atkinson; Maria J. Redondo; Tamara Hannon; Kieren J. Mather; Jay M. Sosenko
Diabetes April 2025, Vol.74, 1196-1204. doi:https://doi.org/10.2337/db24-1000
Complications
miR-214 and Its Primary Transcript Dnm3os Regulate Fibrosis and Inflammation Through RAGE Signaling in Diabetic Kidney Disease
Shinji Hagiwara; Jun Okabe; Mark Ziemann; Brian Drew; Maki Murakoshi; Karly C. Sourris; Aaron D. McClelland; Madhura Bose; Elif Ilhan Ekinci; Melinda T. Coughlan; Adrienne Laskowski; Hiroko Sakuma; Tomohito Gohda; Yusuke Suzuki; Mark E. Cooper; Phillip Kantharidis
Diabetes April 2025, Vol.74, 1205-1219. doi:https://doi.org/10.2337/db24-0121
Neuroprotective Effect of a Novel Soluble Guanylate Cyclase Activator Runcaciguat in Diabetic and Ischemic Retinopathy
Elia J. Duh; Zhenhua Xu; Hongkwan Cho; Shirley Wu; William Schubert; Carsten Terjung; Fabio Baschiera; Lingli Zhou; Lijuan Wu; Grace Lee; Yangyiran Xie; Qiaoyan Hui; James Guerra; Joseph Mertz; Khaled Nassar
Diabetes April 2025, Vol.74, 1220-1232. doi:https://doi.org/10.2337/db24-0739
G Protein–Coupled Receptor 35 Suppresses Oxidative Stress Responsive Kinase 1 in Diabetic Wound Healing
Hainan Li; Liping Xu; Sai Pranathi Meda Venkata; Morgan Minjares; Hassan Melhem; Anjaneyulu Kowluru; Jan Hendrik Niess; Graeme Milligan; Jie-Mei Wang
Diabetes April 2025, Vol.74, 1233-1246. doi:https://doi.org/10.2337/db24-0737
Targeting tsRNA-1797 Alleviates Diabetes-Induced Vascular Dysfunction Through Modulating Purine Metabolism
Duo Li; Jingyue Zhang; Xiaoyan Han; Lingjie Kong; Ying Zhang; Mudi Yao; Ling Ren; Wan Mu; Qin Jiang; Biao Yan
Diabetes April 2025, Vol.74, 1247-1261. doi:https://doi.org/10.2337/db24-1158
Pharmacology and Therapeutics
A Randomized Controlled, Double-Masked, Crossover Study of a GPR119 Agonist on Glucagon Counterregulation During Hypoglycemia in Type 1 Diabetes
Anika Bilal; Anna Casu; Fanchao Yi; Tumpa Dutta; Justine M. Mucinski; Gina Mercouffer; Martin C. Marak; Marcus Hompesch; David Kelley; Richard E. Pratley
Diabetes April 2025, Vol.74, 1262-1272. doi:https://doi.org/10.2337/db25-0096
Liraglutide Treatment Reverses Unconventional Cellular Defects in Induced Pluripotent Stem Cell–Derived β-Cells Harboring a Partially Functional WFS1 Variant
Silvia Torchio; Gabriel Siracusano; Federica Cuozzo; Valentina Zamarian; Silvia Pellegrini; Fabio Manenti; Riccardo Bonfanti; Giulio Frontino; Valeria Sordi; Raniero Chimienti; Lorenzo Piemonti
Diabetes April 2025, Vol.74, 1273-1288. doi:https://doi.org/10.2337/db24-0720
Genetics/Genomes/Proteomics/Metabolomics
Are Polymorphisms Within the Fructosamine-3-Kinase Gene Associated With the Discordance Between HbA1c and Other Measures of Glycemia?
Dipuo D. Motshwari; Cindy George; Elvis N. Ngwa; Annalise E. Zemlin; Andre P. Kengne; Glenda M. Davison; Rajiv T. Erasmus; Tandi E. Matsha
Diabetes April 2025, Vol.74, 1289-1299. doi:https://doi.org/10.2337/db24-0606
Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver
Yunyun Ma; Shiqi Zuo; Therlinder Lo; David Phan; Tyler Finley; Adrienne Mackay; Enrique Trigo; Jaana A. Hartiala; Hooman Allayee; Anny H. Xiang; Thomas A. Buchanan; Richard M. Watanabe
Diabetes April 2025, Vol.74, 1300-1309. doi:https://doi.org/10.2337/db24-0923
