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January 2025
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Cover Image
Cover Image
On the cover: A representative cardiac PET image showing the left ventricle, right ventricle, superior vena cava, and liver. Image courtesy of Ralph A. DeFronzo, Division of Diabetes, Department of Medicine, University of Texas Health Science Center, and Texas Diabetes Institute, University Health System, San Antonio, TX. The article “Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes” appears in this issue of Diabetes (p.
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ISSN 0012-1797
EISSN 1939-327X
Editorial
Perspectives in Diabetes
Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future
Roberto Mallone; Emily Sims; Peter Achenbach; Chantal Mathieu; Alberto Pugliese; Mark Atkinson; Sanjoy Dutta; Carmella Evans-Molina; David Klatzmann; Anne Koralova; S. Alice Long; Lut Overbergh; Teresa Rodriguez-Calvo; Anette-Gabriele Ziegler; Sylvaine You
Diabetes October 2024, Vol.74, 12-21. doi:https://doi.org/10.2337/db24-0439
Technological Advances
Long-term Nerve Regeneration in Diabetic Keratopathy Mediated by a Novel NGF Delivery System
Lin Cong; Benxiang Qi; Shijiu Chen; Ruiling Liu; Suxia Li; Qingjun Zhou; Yihai Cao; Bi Ning Zhang; Lixin Xie
Diabetes October 2024, Vol.74, 22-35. doi:https://doi.org/10.2337/db24-0393
Metabolism
One-Hour Postload Glucose Is a More Sensitive Marker of Impaired β-Cell Function Than Two-Hour Postload Glucose
Jingyi Lu; Jiaying Ni; Hang Su; Xingxing He; Wei Lu; Wei Zhu; Yufei Wang; Xiaojing Ma; Yuqian Bao; Jian Zhou
Diabetes October 2024, Vol.74, 36-42. doi:https://doi.org/10.2337/db24-0652
Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes
Carolina Solis-Herrera; Yuejuan Qin; Henri Honka; Eugenio Cersosimo; Curtis Triplitt; Sivaram Neppala; Jemena Rajan; Francisca M. Acosta; Alexander J. Moody; Patricio Iozzo; Peter Fox; Geoffrey Clarke; Ralph A. DeFronzo
Diabetes October 2024, Vol.74, 43-52. doi:https://doi.org/10.2337/db24-0406
Islet Studies
Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells
Alexander Hamilton; Quan Zhang; Rui Gao; Thomas G. Hill; Albert Salehi; Jakob G. Knudsen; Matthew B. Draper; Paul R.V. Johnson; Patrik Rorsman; Andrei I. Tarasov
Diabetes October 2024, Vol.74, 53-64. doi:https://doi.org/10.2337/db23-0809
Complications
Exploring Structural and Molecular Features of Sciatic Nerve Lesions in Diabetic Neuropathy: Unveiling Pathogenic Pathways and Targets
Daniel Schwarz; Maxime Le Marois; Volker Sturm; Andreas S. Peters; Rémi Longuespée; Dominic Helm; Martin Schneider; Bastian Eichmüller; Asa S. Hidmark; Manuel Fischer; Zoltan Kender; Constantin Schwab; Ingrid Hausser; Joachim Weis; Susanne Dihlmann; Dittmar Böckler; Martin Bendszus; Sabine Heiland; Stephan Herzig; Peter P. Nawroth; Julia Szendroedi; Thomas Fleming
Diabetes October 2024, Vol.74, 65-74. doi:https://doi.org/10.2337/db24-0493
When Does Metabolic Memory Start? Insights From the Association of Medical Diabetologists Annals Initiative on Stringent HbA1c Targets
Giuseppina T. Russo; Antonio Nicolucci; Giuseppe Lucisano; Maria Chiara Rossi; Antonio Ceriello; Francesco Prattichizzo; Valeria Manicardi; Alberto Rocca; Paolo Di Bartolo; Salvatore De Cosmo; Graziano Di Cianni; Riccardo Candido
Diabetes October 2024, Vol.74, 75-81. doi:https://doi.org/10.2337/db24-0166
N6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy
Siguo Feng; Qiuyang Zhang; Qing Liu; Chang Huang; Huiying Zhang; Fengsheng Wang; Yue Zhu; Qizhi Jian; Xue Chen; Qin Jiang; Biao Yan
Diabetes October 2024, Vol.74, 82-95. doi:https://doi.org/10.2337/db24-0691
Induction of a Müller Glial Cell–Specific Protective Pathway Safeguards the Retina From Diabetes-Induced Damage
Cheng-Hui Lin; Man-Ru Wu; Bogdan Tanasa; Praveen Prakhar; Boxiong Deng; Alexander E. Davis; Liang Li; Alexander Xia; Yang Shan; Patrice E. Fort; Sui Wang
Diabetes October 2024, Vol.74, 96-107. doi:https://doi.org/10.2337/db24-0199
Genetics / Genomes / Proteomics / Metabolomics
Evaluating the Causal Effect of Circulating Proteome on Glycemic Traits: Evidence From Mendelian Randomization
Diabetes October 2024, Vol.74, 108-119. doi:https://doi.org/10.2337/db24-0262
Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations
Daniel B. Rosoff; Josephin Wagner; Jeesun Jung; Pal Pacher; Constantinos Christodoulides; George Davey Smith; David Ray; Falk W. Lohoff
Diabetes October 2024, Vol.74, 120-130. doi:https://doi.org/10.2337/db24-0451
