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Perspectives in Diabetes

Leptin: The Tale of an Obesity Gene

José F Caro; Madhur K Sinha; Jerzy W Kolaczynski; Pei Li Zhang; Robert V Considine

View articletitled, Leptin: The Tale of an Obesity Gene

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Topics: genes , leptin , obesity

Diabetes November 1996, Vol.45, 1455-1462. doi:https://doi.org/10.2337/diab.45.11.1455

Original Articles

Disturbed Development of the Preimplantation Embryo in the Insulin-Dependent Diabetic BB/E Rat

Richard G Lea; Jane E McCracken; Susan S McIntyre; William Smith; Joyce D Baird

Abstract

View articletitled, Disturbed Development of the Preimplantation Embryo in the Insulin-Dependent Diabetic BB/E Rat

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Topics: embryo , insulin , fetal death , diabetes mellitus, type 1

Diabetes November 1996, Vol.45, 1463-1470. doi:https://doi.org/10.2337/diab.45.11.1463

Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [¹⁵O]H₂O, [¹⁸F]fluoro-2-deoxy-D-glucose, and Positron Emission Tomography

Maria Raitakari; Pirjo Nuutila; Ulla Ruotsalainen; Hanna Laine; Mika Teräs; Hidehiro Iida; Sari Mäkimattila; Tapio Utriainen; Vesa Oikonen; Hannu Sipilä; Merja Haaparanta; Olof Solin; Uno Wegelius; Juhani Knuuti; Hannele Yki-Järvinen

Abstract

View articletitled, Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and Positron Emission Tomography

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Topics: dissociation , glucose , glucose uptake , insulin , positron-emission tomography

Diabetes November 1996, Vol.45, 1471-1477. doi:https://doi.org/10.2337/diab.45.11.1471

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

Hirotaka Watada; Yoshitaka Kajimoto; Yutaka Umayahara; Taka-aki Matsuoka; Hideaki Kaneto; Yoshi Fujitani; Takenobu Kamada; Ryuzo Kawamori; Yoshimitsu Yamasaki

Abstract

View articletitled, The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

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Topics: fibrinogen , genes , glucokinase , insulin

Diabetes November 1996, Vol.45, 1478-1488. doi:https://doi.org/10.2337/diab.45.11.1478

Glycation of Insulin in the Islets of Langerhans of Normal and Diabetic Animals

Yasser H A Abdel-Wahab; Finbarr P O'Harte; Helen Ratcliff; Neville H McClenaghan; Christopher R Barnett; Peter R Flatt

Abstract

View articletitled, Glycation of Insulin in the Islets of Langerhans of Normal and Diabetic Animals

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Topics: endocrine pancreas , glycation , insulin

Diabetes November 1996, Vol.45, 1489-1496. doi:https://doi.org/10.2337/diab.45.11.1489

Pregnant Diabetic Rats Fed the Antioxidant Butylated Hydroxytoluene Show Decreased Occurrence of Malformations in Offspring

Ulf J Eriksson; C Martin Simán

Abstract

View articletitled, Pregnant Diabetic Rats Fed the Antioxidant Butylated Hydroxytoluene Show Decreased Occurrence of Malformations in Offspring

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Topics: antioxidants , butylated hydroxytoluene , congenital abnormality , pregnancy , rats

Diabetes November 1996, Vol.45, 1497-1502. doi:https://doi.org/10.2337/diab.45.11.1497

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Maria M Byrne; Jeppe Sturis; Stephan Menzel; Kazuya Yamagata; Stefan S Fajans; Mark J Dronsfield; Stephen C Bain; Andrew T Hattersley; Gilberto Velho; Phillipe Froguel; Graeme I Bell; Kenneth S Polonsky

Abstract

View articletitled, Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

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Topics: chromosomes, human, pair 12 , genes , glucose , insulin , mutation

Diabetes November 1996, Vol.45, 1503-1510. doi:https://doi.org/10.2337/diab.45.11.1503

Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

Jerzy W Kolaczynski; Robert V Considine; Joanna Ohannesian; Cheryl Marco; Irina Opentanova; Mark R Nyce; Michael Myint; Jasé F Caro

Abstract

View articletitled, Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

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Topics: fasting , ketogenesis , ketones , leptin , refeeding syndrome

Diabetes November 1996, Vol.45, 1511-1515. doi:https://doi.org/10.2337/diab.45.11.1511

Muscle Subcellular Localization and Recruitment by Insulin of Glucose Transporters and Na⁺-K⁺-ATPase Subunits in Transgenic Mice Overexpressing the GLUT4 Glucose Transporter

Toolsie Ramlal; H Stephen Ewart; Romel Somwar; Rhonda O Deems; Michele A Valentin; Douglas A Young; Amira Klip

Abstract

View articletitled, Muscle Subcellular Localization and Recruitment by Insulin of Glucose Transporters and Na+-K+-ATPase Subunits in Transgenic Mice Overexpressing the GLUT4 Glucose Transporter

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Topics: adenosine triphosphatases , glucose transporter , insulin , mice, transgenic

Diabetes November 1996, Vol.45, 1516-1523. doi:https://doi.org/10.2337/diab.45.11.1516

Normalization of Insulin Responses to Glucose by Overnight Infusion of Glucagon-Like Peptide 1 (7–36) Amide in Patients With NIDDM

Jonathan Rachman; Fiona M Gribble; Beryl A Barrow; Jonathan C Levy; Keith D Buchanan; Robert C Turner

Abstract

View articletitled, Normalization of Insulin Responses to Glucose by Overnight Infusion of Glucagon-Like Peptide 1 (7–36) Amide in Patients With NIDDM

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Topics: amides , diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose , infusion procedures

Diabetes November 1996, Vol.45, 1524-1530. doi:https://doi.org/10.2337/diab.45.11.1524

Inhibition of Mitochondrial Complex I May Account for IDDM Induced by Intoxication With the Rodenticide Vacor

Mauro D Esposti; Anna Ngo; Mark A Myers

Abstract

View articletitled, Inhibition of Mitochondrial Complex I May Account for IDDM Induced by Intoxication With the Rodenticide Vacor

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Topics: diabetes mellitus, type 1 , intoxication , mitochondria , pyriminil , rodenticides

Diabetes November 1996, Vol.45, 1531-1534. doi:https://doi.org/10.2337/diab.45.11.1531

Genetic Control of Giant Perivascular Space Formation in the Thymus of NOD Mice

Evelyne Colomb; Wilson Savino; Linda Wicker; Larry Peterson; Mireille Dardenne; Claude Carnaud

Abstract

View articletitled, Genetic Control of Giant Perivascular Space Formation in the Thymus of NOD Mice

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Topics: gene expression regulation , mice, inbred nod , thymus gland

Diabetes November 1996, Vol.45, 1535-1540. doi:https://doi.org/10.2337/diab.45.11.1535

β-Cell Growth and Mass Are Preserved in Long-Term Syngeneic Islet Transplantation in Streptozocin-Induced Diabetic Lewis Rats

Victor Nácher; Mercè Raurell; J Francisco Merino; Olga Aranda; Joan Soler; Eduard Montana

Abstract

View articletitled, β-Cell Growth and Mass Are Preserved in Long-Term Syngeneic Islet Transplantation in Streptozocin-Induced Diabetic Lewis Rats

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Topics: islets of langerhans transplantation , rats , streptozocin

Diabetes November 1996, Vol.45, 1541-1546. doi:https://doi.org/10.2337/diab.45.11.1541

Insulin Sensitivity and Abdominal Obesity in African-American, Hispanic, and Non-Hispanic White Men and Women: The Insulin Resistance and Atherosclerosis Study

Andrew J Karter; Elizabeth J Mayer-Davis; Joe V Selby; Ralph B D'Agostino, Jr; Steven M Haffner; Phyliss Sholinsky; Richard Bergman; Mohammed F Saad; Richard F Hamman

Abstract

View articletitled, Insulin Sensitivity and Abdominal Obesity in African-American, Hispanic, and Non-Hispanic White Men and Women: The Insulin Resistance and Atherosclerosis Study

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Topics: atherosclerosis , insulin resistance , insulin sensitivity , obesity, abdominal

Diabetes November 1996, Vol.45, 1547-1555. doi:https://doi.org/10.2337/diab.45.11.1547

Troglitazone Inhibits Fatty Acid Oxidation and Esterification, and Gluconeogenesis in Isolated Hepatocytes from Starved Rats

Jean-Pierre Fulgencio; Claude Kohl; Jean Girard; Jean-Paul Pégorier

Abstract

View articletitled, Troglitazone Inhibits Fatty Acid Oxidation and Esterification, and Gluconeogenesis in Isolated Hepatocytes from Starved Rats

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Topics: esterification , fatty acid oxidation , gluconeogenesis , hepatocytes , rats

Diabetes November 1996, Vol.45, 1556-1562. doi:https://doi.org/10.2337/diab.45.11.1556

Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence

Doriane Argaud; Qing Zhang; Wansong Pan; Subir Maitra; Simon J Pilkis; Alex J Lange

Abstracts

View articletitled, Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence

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Topics: gene expression , gene organization , glucose-6-phosphatase , liver

Diabetes November 1996, Vol.45, 1563-1571. doi:https://doi.org/10.2337/diab.45.11.1563

Effect of Troglitazone on Insulin Sensitivity and Pancreatic β-Cell Function in Women at High Risk for NIDDM

Kathleen Berkowitz; Ruth Peters; Siri L Kjos; Jose Goico; Aura Marroquin; Meleana E Dunn; Anny Xiang; Stanley Azen; Thomas A Buchanan

Abstract

View articletitled, Effect of Troglitazone on Insulin Sensitivity and Pancreatic β-Cell Function in Women at High Risk for NIDDM

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Topics: diabetes mellitus, type 2 , insulin sensitivity , pancreas , troglitazone

Diabetes November 1996, Vol.45, 1572-1579. doi:https://doi.org/10.2337/diab.45.11.1572

Plasma Leptin Levels Correlate to Islet Function Independently of Body Fat in Postmenopausal Women

Hillevi Larsson; Sö Elmståhl; Bo Ahrén

Abstract

View articletitled, Plasma Leptin Levels Correlate to Islet Function Independently of Body Fat in Postmenopausal Women

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Topics: body fat , leptin , plasma , postmenopause

Diabetes November 1996, Vol.45, 1580-1584. doi:https://doi.org/10.2337/diab.45.11.1580

Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects

Leif Groop; Carol Forsblom; Mikko Lehtovirta; Tlinamaija Tuomi; Samuel Karanko; Michael Nissén; Bjorn-Olof Ehrnström; Björn Forsén; Bo Isomaa; Börje Snickars; Marja-Riitta Taskinen

Abstract

View articletitled, Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects

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Topics: diabetes mellitus, type 2 , family history

Diabetes November 1996, Vol.45, 1585-1593. doi:https://doi.org/10.2337/diab.45.11.1585

A Comparison of the Effects of Selective Increases in Peripheral or Portal insulin on Hepatic Glucose Production in the Conscious Dog

Dana K Sindelar; James H Balcom; Chang A Chu; Doss W Neal; Alan D Cherrington

Abstract

View articletitled, A Comparison of the Effects of Selective Increases in Peripheral or Portal insulin on Hepatic Glucose Production in the Conscious Dog

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Topics: dog, domestic , glucose , insulin

Diabetes November 1996, Vol.45, 1594-1604. doi:https://doi.org/10.2337/diab.45.11.1594

The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913

Gösta Tibblin; Annika Adlerberth; Göran Lindstedt; Per Björntorp

Abstract

View articletitled, The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913

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Topics: older adult , pituitary-gonadal axis , obesity, abdominal , sex hormone-binding globulin , testosterone

Diabetes November 1996, Vol.45, 1605-1609. doi:https://doi.org/10.2337/diab.45.11.1605

Imidazoline Compounds Stimulate Insulin Release by Inhibition of K_ATP Channels and Interaction With the Exocytotic Machinery

Sergei V Zaitsev; Alexandre M Efanov; Ioulia B Efanova; Olof Larsson; Claes-Göran Ostenson; Gerald Gold; Per-Olof Berggren; Suad Efendić

Abstract

View articletitled, Imidazoline Compounds Stimulate Insulin Release by Inhibition of KATP Channels and Interaction With the Exocytotic Machinery

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Topics: imidazolines , insulin

Diabetes November 1996, Vol.45, 1610-1618. doi:https://doi.org/10.2337/diab.45.11.1610

Epidermal Growth Factor Induces Glucose Storage in Transgenic 3T3-L1 Adipocytes Overexpressing Epidermal Growth Factor Receptors

Mark Van Epps-Fung; Robert W Hardy; Jodie Williford; Kiran Gupta; Alan Wells

Abstract

View articletitled, Epidermal Growth Factor Induces Glucose Storage in Transgenic 3T3-L1 Adipocytes Overexpressing Epidermal Growth Factor Receptors

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Topics: adipocytes , animals, transgenic , epidermal growth factor , epidermal growth factor receptors , glucose

Diabetes November 1996, Vol.45, 1619-1625. doi:https://doi.org/10.2337/diab.45.11.1619

Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of Zucker Diabetic Fatty Rats

Michael J MacDonald; Jiping Tang; Kenneth S Polonsky

Abstract

View articletitled, Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of Zucker Diabetic Fatty Rats

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Topics: endocrine pancreas , glycerol , mitochondria , oxidoreductase , phosphates

Diabetes November 1996, Vol.45, 1626-1630. doi:https://doi.org/10.2337/diab.45.11.1626

Nicotinamide's Effects on Glucose Metabolism in Subjects at Risk For IDDM

Carla J Greenbaum; Steven E Kahn; Jerry P Palmer

Abstract

View articletitled, Nicotinamide's Effects on Glucose Metabolism in Subjects at Risk For IDDM

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Topics: diabetes mellitus, type 1 , glucose metabolism

Diabetes November 1996, Vol.45, 1631-1634. doi:https://doi.org/10.2337/diab.45.11.1631

Rapid Publications

Leptin: A Significant Indicator of Total Body Fat but Not of Visceral Fat and Insulin Insensitivity in African-American Women

Arnavaz Dua; Magda I Hennes; Raymond G Hoffmann; Diana L Maas; Glenn R Krakower; Gabriele E Sonnenberg; Ahmed H Kissebah

Abstract

View articletitled, Leptin: A Significant Indicator of Total Body Fat but Not of Visceral Fat and Insulin Insensitivity in African-American Women

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Topics: body fat , insulin , leptin , visceral fat

Diabetes November 1996, Vol.45, 1635-1637. doi:https://doi.org/10.2337/diab.45.11.1635

Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity

Karen L Houseknecht; Chris S Mantzoros; Regina Kuliawat; Edward Hadro; Jeffrey S Flier; Barbara B Kahn

Abstract

View articletitled, Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity

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Topics: leptin , obesity , rodentia

Diabetes November 1996, Vol.45, 1638-1643. doi:https://doi.org/10.2337/diab.45.11.1638

Lilly lecture 1995

Glucose Transport: Pivotal Step in Insulin Action

Barbara B Kahn

Abstract

View articletitled, Glucose Transport: Pivotal Step in Insulin Action

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Topics: glucose transport , insulin

Diabetes November 1996, Vol.45, 1644-1654. doi:https://doi.org/10.2337/diab.45.11.1644

Erratum

View articletitled, Erratum

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Diabetes November 1996, Vol.45, 1655. doi:https://doi.org/10.2337/diab.45.11.1655

Organization Section

View articletitled, Organization Section

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Diabetes November 1996, Vol.45, 1656-1658. doi:https://doi.org/10.2337/diab.45.11.1656

SI Units Table

Système International (SI) Units Table

View articletitled, Système International (SI) Units Table

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Diabetes November 1996, Vol.45, 1659-1660. doi:https://doi.org/10.2337/diab.45.11.1659

Issues

Perspectives in Diabetes

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Lilly lecture 1995

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SI Units Table

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