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Volume 45, Issue 12

1 December 1996

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Front Matter
Back Matter

ISSN 0012-1797

EISSN 1939-327X

In this Issue

Perspectives in Diabetes
Original Articles
Rapid Publications
Organization Section
SI Units Table
1996 Subject and Author Indexes

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Perspectives in Diabetes

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

Alan R Saltiel; Jerrold M Olefsky

Abstract

View articletitled, Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

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Topics: diabetes mellitus, type 2 , insulin resistance , thiazolidinedione

Diabetes December 1996, Vol.45, 1661-1669. doi:https://doi.org/10.2337/diab.45.12.1661

Original Articles

Heterologous Expression and Characterization of Rat Liver Glucokinase Regulatory Protein

Kasim A Mookhtiar; Stephen S Kalinowski; Karen S Brown; Yim Ha Tsay; Constance Smith-Monroy; Gordon W Robinson

Abstract

View articletitled, Heterologous Expression and Characterization of Rat Liver Glucokinase Regulatory Protein

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Topics: glucokinase , liver , regulatory protein

Diabetes December 1996, Vol.45, 1670-1677. doi:https://doi.org/10.2337/diab.45.12.1670

Abnormally Expressed Low-Voltage-Activated Calcium Channels in β-Cells From NOD Mice and a Related Clonal Cell Line

Lin Wang; Arin Bhattacharjee; Jian Fu; Ming Li

Abstract

View articletitled, Abnormally Expressed Low-Voltage-Activated Calcium Channels in β-Cells From NOD Mice and a Related Clonal Cell Line

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Topics: calcium channels , cell lines , mice, inbred nod

Diabetes December 1996, Vol.45, 1678-1683. doi:https://doi.org/10.2337/diab.45.12.1678

Relationship of Generalized and Regional Adiposity to Insulin Sensitivity in Men With NIDDM

Nicola Abate; Abhimanyu Garg; Ronald M Peshock; James Stray-Gundersen; Beverley Adams-Huet; Scott M Grundy

Abstract

View articletitled, Relationship of Generalized and Regional Adiposity to Insulin Sensitivity in Men With NIDDM

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Topics: diabetes mellitus, type 2 , insulin sensitivity , obesity

Diabetes December 1996, Vol.45, 1684-1693. doi:https://doi.org/10.2337/diab.45.12.1684

Chronic Dosing With Aminoguanidine and Novel Advanced Glycosylation End Product-Formation Inhibitors Ameliorates Cross-Linking of Tail Tendon Collagen in STZ-Induced Diabetic Rats

Maral Kochakian; Belur N Manjula; John J Egan

Abstract

View articletitled, Chronic Dosing With Aminoguanidine and Novel Advanced Glycosylation End Product-Formation Inhibitors Ameliorates Cross-Linking of Tail Tendon Collagen in STZ-Induced Diabetic Rats

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Topics: collagen , cross-linking , glycosylation , pimagedine , rats

Diabetes December 1996, Vol.45, 1694-1700. doi:https://doi.org/10.2337/diab.45.12.1694

Identification of Two Missense Mutations in the GIP Receptor Gene: A Functional Study and Association Analysis with NIDDM: No Evidence of Association with Japanese NIDDM Subjects

Akira Kubota; Yuichiro Yamada; Tadao Hayami; Koichiro Yasuda; Yoshimichi Someya; Yu Ihara; Shinji Kagimoto; Rie Watanabe; Tomohiko Taminato; Kinsuke Tsuda; Yutaka Seino

Abstract

View articletitled, Identification of Two Missense Mutations in the GIP Receptor Gene: A Functional Study and Association Analysis with NIDDM: No Evidence of Association with Japanese NIDDM Subjects

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Topics: diabetes mellitus, type 2 , genes , missense mutation

Diabetes December 1996, Vol.45, 1701-1705. doi:https://doi.org/10.2337/diab.45.12.1701

Disease-Associated Antibodies in Offspring of Mothers with IDDM

Anu Martikainen; Tero Saukkonen; Petri K Kulmala; Helena Reijonen; Jorma Ilonen; Kari Teramo; Pentti Koskela; Mikael Knip; Hans K Åkerblom

Abstract

View articletitled, Disease-Associated Antibodies in Offspring of Mothers with IDDM

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Topics: antibodies , diabetes mellitus, type 1

Diabetes December 1996, Vol.45, 1706-1710. doi:https://doi.org/10.2337/diab.45.12.1706

Major Histocompatibility Complex Class II Molecules Function as a Template for the Processing of a Partially Processed Insulin Peptide into a T-cell Epitope

Ying Lang; Frederique Forquet; Edwin Speck; Janice Blum; Terry L Delovitch

Abstract

View articletitled, Major Histocompatibility Complex Class II Molecules Function as a Template for the Processing of a Partially Processed Insulin Peptide into a T-cell Epitope

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Topics: histocompatibility antigens class ii , insulin , molecule , peptides , t-lymphocyte epitopes

Diabetes December 1996, Vol.45, 1711-1719. doi:https://doi.org/10.2337/diab.45.12.1711

Interactions of Age, Islet Cell Antibodies, Insulin Autoantibodies, and First-Phase Insulin Response in Predicting Risk of Progression to IDDM in ICA⁺ Relatives: The ICARUS Data Set

Polly J Bingley

Abstract

View articletitled, Interactions of Age, Islet Cell Antibodies, Insulin Autoantibodies, and First-Phase Insulin Response in Predicting Risk of Progression to IDDM in ICA+ Relatives: The ICARUS Data Set

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Topics: antibodies , autoantibodies , datasets , diabetes mellitus, type 1 , endocrine pancreas

Diabetes December 1996, Vol.45, 1720-1728. doi:https://doi.org/10.2337/diab.45.12.1720

Glomerular Hyperfiltration in the Prediction of Nephropathy in IDDM: A 10-Year Follow-Up Study

Jeannie W Yip; Sharon L Jones; Martin J Wiseman; Caron Hill; Giancarlo Viberti

Abstract

View articletitled, Glomerular Hyperfiltration in the Prediction of Nephropathy in IDDM: A 10-Year Follow-Up Study

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Topics: diabetes mellitus, type 1 , follow-up , kidney diseases , kidney glomerulus

Diabetes December 1996, Vol.45, 1729-1733. doi:https://doi.org/10.2337/diab.45.12.1729

Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

Meredith Hawkins; Nir Barzilai; Wei Chen; Ivo Angelov; Meizhu Hu; Pinchas Cohen; Luciano Rossetti

Abstract

View articletitled, Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

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Topics: glucose , hexosamines , insulin , insulin-like growth factor i

Diabetes December 1996, Vol.45, 1734-1743. doi:https://doi.org/10.2337/diab.45.12.1734

Reduced Expression of the Leptin Gene (ob) by Catecholamine Through a G_S Protein-Coupled Pathway in 3T3-L1 Adipocytes

Atsushi Kosaki; Kazunori Yamada; Hideshi Kuzuya

Abstract

View articletitled, Reduced Expression of the Leptin Gene (ob) by Catecholamine Through a GS Protein-Coupled Pathway in 3T3-L1 Adipocytes

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Topics: adipocytes , catecholamines , genes , leptin

Diabetes December 1996, Vol.45, 1744-1749. doi:https://doi.org/10.2337/diab.45.12.1744

Immunologic Effects of Insulin Lispro [Lys (B28), Pro (B29) Human Insulin] in IDDM and NIDDM Patients Previously Treated With Insulin

Naomi S Fineberg; S Edwin Fineberg; James H Anderson; Martin A Birkett; Reid G Gibson; Suzan Hufferd

Abstract

View articletitled, Immunologic Effects of Insulin Lispro [Lys (B28), Pro (B29) Human Insulin] in IDDM and NIDDM Patients Previously Treated With Insulin

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Topics: diabetes mellitus, type 1 , diabetes mellitus, type 2 , immunology , insulin , insulin lispro

Diabetes December 1996, Vol.45, 1750-1754. doi:https://doi.org/10.2337/diab.45.12.1750

Diminished Fraction of Blockable ATP-Sensitive K⁺ Channels in Islets Transplanted Into Diabetic Mice

Bernat Soria; Franz Martín; Etelvina Andreu; Juan V Sanchez-Andrés; Victor Nacher; Eduard Montana

Abstract

View articletitled, Diminished Fraction of Blockable ATP-Sensitive K+ Channels in Islets Transplanted Into Diabetic Mice

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Topics: mice , glucose

Diabetes December 1996, Vol.45, 1755-1760. doi:https://doi.org/10.2337/diab.45.12.1755

Tissue-Specific Self-Peptides Bound by Major Histocompatibility Complex Class I Molecules of a Human Pancreatic β-cell Line

Kyriakos P Papadopoulos; Adrianna I Colovai; Antonella Maffei; Dolores Jaraquemada; Nicole Suciu-Foca; Paul E Harris

Abstract

View articletitled, Tissue-Specific Self-Peptides Bound by Major Histocompatibility Complex Class I Molecules of a Human Pancreatic β-cell Line

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Topics: major histocompatibility complex , molecule , pancreas , peptides

Diabetes December 1996, Vol.45, 1761-1765. doi:https://doi.org/10.2337/diab.45.12.1761

The βHC-9 Pancreatic β-Cell Line Preserves the Characteristics of Progenitor Mouse Islets

Mitsuhiko Noda; Mitsuhisa Komatsu; Geoffrey W G Sharp

Abstract

View articletitled, The βHC-9 Pancreatic β-Cell Line Preserves the Characteristics of Progenitor Mouse Islets

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Topics: mice , pancreas , glucose , insulin

Diabetes December 1996, Vol.45, 1766-1773. doi:https://doi.org/10.2337/diab.45.12.1766

Effects of Chronically Elevated Glucose Levels on the Functional Properties of Rat Pancreatic β-Cells

Zhidong Ling; Rita Kiekens; Tania Mahler; Frans C Schuit; Miriam Pipeleers-Marichal; Abdullah Sener; Gunther Klöppel; Willy J Malaisse; Daniel G Pipeleers

Abstract

View articletitled, Effects of Chronically Elevated Glucose Levels on the Functional Properties of Rat Pancreatic β-Cells

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Topics: hyperglycemia , pancreas

Diabetes December 1996, Vol.45, 1774-1782. doi:https://doi.org/10.2337/diab.45.12.1774

Dual Functional Effects of Interleukin-1β on Purine Nucleotides and Insulin Secretion in Rat Islets and INS-1 Cells

Melissa Meredith; Mary E Rabaglia; John A Corbett; Stewart A Metz

Abstract

View articletitled, Dual Functional Effects of Interleukin-1β on Purine Nucleotides and Insulin Secretion in Rat Islets and INS-1 Cells

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Topics: insulin secretion , interleukins , purine nucleotides

Diabetes December 1996, Vol.45, 1783-1791. doi:https://doi.org/10.2337/diab.45.12.1783

Mechanisms of Sulfonylurea's Stimulation of Insulin Secretion In Vivo: Selective Amplification of Insulin Secretory Burst Mass

Niels K Pørksen; Stephen R Munn; Jeffery L Steers; Ole Schmitz; Johannes D Veldhuis; Peter C Butler

Abstract

View articletitled, Mechanisms of Sulfonylurea's Stimulation of Insulin Secretion In Vivo: Selective Amplification of Insulin Secretory Burst Mass

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Topics: amplification , insulin , insulin secretion

Diabetes December 1996, Vol.45, 1792-1797. doi:https://doi.org/10.2337/diab.45.12.1792

Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway

D Elizabeth Estrada; H Stephen Ewart; Theodoros Tsakiridis; Allen Volchuk; Toolsie Ramlal; Hans Tritschler; Amira Klip

Abstract

View articletitled, Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway

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Topics: coenzymes , glucose uptake , insulin signaling pathway , thioctic acid

Diabetes December 1996, Vol.45, 1798-1804. doi:https://doi.org/10.2337/diab.45.12.1798

In the Absence of Counterregulatory Hormones, the Increase in Hepatic Glucose Production During Insulin-Induced Hypoglycemia in the Dog Is Initiated in the Liver Rather Than the Brain

Cynthia C Connolly; Sharon R Myers; Doss W Neal; Jon R Hastings; Alan D Cherrington

Abstract

View articletitled, In the Absence of Counterregulatory Hormones, the Increase in Hepatic Glucose Production During Insulin-Induced Hypoglycemia in the Dog Is Initiated in the Liver Rather Than the Brain

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Topics: brain , dog, domestic , glucose , hormones , hypoglycemia

Diabetes December 1996, Vol.45, 1805-1813. doi:https://doi.org/10.2337/diab.45.12.1805

Long-Term Metabolic Control by Rat Islet Grafts Depends on the Composition of the Implant

Bart Keymeulen; Greg Korbutt; Monique De Paepe; Frans Gorus; Gönter Klöppel; Daniel G Pipeleers

Abstract

View articletitled, Long-Term Metabolic Control by Rat Islet Grafts Depends on the Composition of the Implant

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Topics: implants , tissue transplants

Diabetes December 1996, Vol.45, 1814-1821. doi:https://doi.org/10.2337/diab.45.12.1814

Rapid Publications

Troglitazone Attenuates High-Glucose–Induced Abnormalities in Relaxation and Intracellular Calcium in Rat Ventricular Myocytes

Jun Ren; Ligia J Dominguez; James R Sowers; Amy J Davidoff

Abstract

View articletitled, Troglitazone Attenuates High-Glucose–Induced Abnormalities in Relaxation and Intracellular Calcium in Rat Ventricular Myocytes

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Topics: calcium , glucose , troglitazone , ventricular myocytes

Diabetes December 1996, Vol.45, 1822-1825. doi:https://doi.org/10.2337/diab.45.12.1822

PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

Hirotaka Watada; Yoshitaka Kajimoto; Jun-ichiro Miyagawa; Toshiaki Hanafusa; Kazuyuki Hamaguchi; Taka-aki Matsuoka; Koji Yamamoto; Yuji Matsuzawa; Ryuzo Kawamori; Yoshimitsu Yamasaki

Abstract

View articletitled, PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

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Topics: betacellulin , clone cells , gene expression , glucokinase , insulin

Diabetes December 1996, Vol.45, 1826-1831. doi:https://doi.org/10.2337/diab.45.12.1826

Organization Section

View articletitled, Organization Section

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Diabetes December 1996, Vol.45, 1832-1833. doi:https://doi.org/10.2337/diab.45.12.1832

SI Units Table

Système International (SI) Units Table

View articletitled, Système International (SI) Units Table

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Diabetes December 1996, Vol.45, 1834. doi:https://doi.org/10.2337/diab.45.12.1834

1996 Subject and Author Indexes

View articletitled, 1996 Subject and Author Indexes

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Diabetes December 1996, Vol.45, 1835-1845. doi:https://doi.org/10.2337/diab.45.12.1835

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