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Perspectives in Diabetes

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

Shane Rea; David E James

Abstract

View articletitled, Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

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Topics: origin of life , vesicle

Diabetes November 1997, Vol.46, 1667-1677. doi:https://doi.org/10.2337/diab.46.11.1667

Original Articles

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

Philip D G Miles; Oreste M Romeo; Katsuya Higo; Aaron Cohen; Karim Rafaat; Jerrold M Olefsky

Abstract

View articletitled, TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

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Topics: insulin resistance , troglitazone , tumor necrosis factors

Diabetes November 1997, Vol.46, 1678-1683. doi:https://doi.org/10.2337/diab.46.11.1678

Vanadate Activates Membranous Nonreceptor Protein Tyrosine Kinase in Rat Adipocytes

Gerard Elberg; Zhibin He; Jinping Li; Natesampillai Sekar; Yoram Shechter

Abstract

View articletitled, Vanadate Activates Membranous Nonreceptor Protein Tyrosine Kinase in Rat Adipocytes

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Topics: adipocytes , protein tyrosine kinase , tissue membrane , vanadates

Diabetes November 1997, Vol.46, 1684-1690. doi:https://doi.org/10.2337/diab.46.11.1684

Expression of Nitric Oxide Synthase in Skeletal Muscle: A Novel Role for Nitric Oxide as a Modulator of Insulin Action

Sonia Kapur; Sylvain Bédard; Bruno Marcotte; Claude H Côté; André Marette

Abstract

View articletitled, Expression of Nitric Oxide Synthase in Skeletal Muscle: A Novel Role for Nitric Oxide as a Modulator of Insulin Action

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Topics: insulin , nitric oxide , nitric oxide synthase , skeletal muscles

Diabetes November 1997, Vol.46, 1691-1700. doi:https://doi.org/10.2337/diab.46.11.1691

Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers

Polly J Bingley; Ezio Bonifacio; Alistair J K Williams; Stefano Genovese; Gian Franco Bottazzo; Edwin A M Gale

Abstract

View articletitled, Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers

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Topics: autoantibodies , diabetes mellitus, type 1

Diabetes November 1997, Vol.46, 1701-1710. doi:https://doi.org/10.2337/diab.46.11.1701

Cow's Milk–Free Diet Does Not Prevent Diabetes in NOD Mice

Jessica A Paxson; Jennifer G Weber; Anthony Kulczycki, Jr

Abstract

View articletitled, Cow's Milk–Free Diet Does Not Prevent Diabetes in NOD Mice

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Topics: cow's milk , diabetes prevention , diet , mice, inbred nod

Diabetes November 1997, Vol.46, 1711-1717. doi:https://doi.org/10.2337/diab.46.11.1711

Impaired β-Cell Function and Deposition of Fat Droplets in the Pancreas as a Consequence of Hypertriglyceridemia in OLETF Rat, a Model of Spontaneous NIDDM

Zhi-Wei Man; Min Zhu; Yoshihiko Noma; Kiyotaka Toide; Takashi Sato; Yoshihiko Asahi; Tsukasa Hirashima; Shigehito Mori; Kazuya Kawano; Akira Mizuno; Toshiaki Sano; Kenji Shima

Abstract

View articletitled, Impaired β-Cell Function and Deposition of Fat Droplets in the Pancreas as a Consequence of Hypertriglyceridemia in OLETF Rat, a Model of Spontaneous NIDDM

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Topics: diabetes mellitus, type 2 , hypertriglyceridemia , pancreas , rats, inbred oletf

Diabetes November 1997, Vol.46, 1718-1724. doi:https://doi.org/10.2337/diab.46.11.1718

Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM

Steven E Kahn; Philippe A Halban

Abstract

View articletitled, Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM

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Topics: diabetes mellitus, type 2 , proinsulin

Diabetes November 1997, Vol.46, 1725-1732. doi:https://doi.org/10.2337/diab.46.11.1725

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

Markus Tiedge; Stephan Lortz; Jens Drinkgern; Sigurd Lenzen

Abstract

View articletitled, Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

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Topics: antioxidants , enzymes , gene expression , insulin

Diabetes November 1997, Vol.46, 1733-1742. doi:https://doi.org/10.2337/diab.46.11.1733

A Nonsense Mutation in the Inward Rectifier Potassium Channel Gene, Kir6.2, Is Associated With Familial Hyperinsulinism

Ann Nestorowicz; Nobuya Inagaki; Tohru Gonoi; Kathleen P Schoor; Beth Anne Wilson; Benjamin Glaser; Heddy Landau; Charles A Stanley; Paul S Thornton; Susumu Seino; M Alan Permutt

Abstract

View articletitled, A Nonsense Mutation in the Inward Rectifier Potassium Channel Gene, Kir6.2, Is Associated With Familial Hyperinsulinism

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Topics: genes , hyperinsulinism , inward rectifier potassium channel , mutation, nonsense

Diabetes November 1997, Vol.46, 1743-1748. doi:https://doi.org/10.2337/diab.46.11.1743

Diminished Insulin and Glucagon Secretory Responses to Arginine in Nondiabetic Subjects With a Mutation in the Hepatocyte Nuclear Factor–4α/MODY1 Gene

William H Herman; Stefan S Fajans; Maria J Smith; Kenneth S Polonsky; Graeme I Bell; Jeffrey B Halter

Abstract

View articletitled, Diminished Insulin and Glucagon Secretory Responses to Arginine in Nondiabetic Subjects With a Mutation in the Hepatocyte Nuclear Factor–4α/MODY1 Gene

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Topics: arginine , genes , glucagon , hepatocytes , insulin

Diabetes November 1997, Vol.46, 1749-1754. doi:https://doi.org/10.2337/diab.46.11.1749

GLP-I(7–36) Amide Augments Ba²⁺ Current Through L-Type Ca²⁺ Channel of Rat Pancreatic β-Cell in a cAMP-Dependent Manner

Sechiko Suga; Takahiro Kanno; Kyoko Nakano; Teruko Takeo; Yoshifusa Dobashi; Makoto Wakui

Abstract

View articletitled, GLP-I(7–36) Amide Augments Ba2+ Current Through L-Type Ca2+ Channel of Rat Pancreatic β-Cell in a cAMP-Dependent Manner

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Topics: amides , cyclic amp , pancreas

Diabetes November 1997, Vol.46, 1755-1760. doi:https://doi.org/10.2337/diab.46.11.1755

Insulin Resistance of Muscle Glucose Transport in Rats Fed a High-Fat Diet: A Reevaluation

Dong-Ho Han; Polly A Hansen; Helen H Host; John O Holloszy

Abstract

View articletitled, Insulin Resistance of Muscle Glucose Transport in Rats Fed a High-Fat Diet: A Reevaluation

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Topics: diet, high-fat , glucose transport , insulin resistance , rats

Diabetes November 1997, Vol.46, 1761-1767. doi:https://doi.org/10.2337/diab.46.11.1761

Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding

Nicholas D Oakes; Gregory J Cooney; Souad Camilleri; Donald J Chisholm; Edward W Kraegen

Abstract

View articletitled, Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding

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Topics: insulin resistance , liver

Diabetes November 1997, Vol.46, 1768-1774. doi:https://doi.org/10.2337/diab.46.11.1768

Insulin Signaling in Human Skeletal Muscle: Time Course and Effect of Exercise

Jørgen F P Wojtaszewski; Bo F Hansen; Bente Kiens; Erik A Richter

Abstract

View articletitled, Insulin Signaling in Human Skeletal Muscle: Time Course and Effect of Exercise

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Topics: insulin , signal transduction , skeletal muscles , time factors

Diabetes November 1997, Vol.46, 1775-1781. doi:https://doi.org/10.2337/diab.46.11.1775

Inhibition of Food Response to Intracerebroventricular Injection of Leptin Is Attenuated in Rats With Diet-Induced Obesity

P S Widdowson; R Upton; R Buckingham; J Arch; G Williams

Abstract

View articletitled, Inhibition of Food Response to Intracerebroventricular Injection of Leptin Is Attenuated in Rats With Diet-Induced Obesity

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Topics: attenuation , diet , leptin , obesity , rats

Diabetes November 1997, Vol.46, 1782-1785. doi:https://doi.org/10.2337/diab.46.11.1782

Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals With Type 2 Diabetes

Richard A Anderson; Nanzheng Cheng; Noella A Bryden; Marilyn M Polansky; Nanping Cheng; Jiaming Chi; Jinguang Feng

Abstract

View articletitled, Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals With Type 2 Diabetes

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Topics: chromium , diabetes mellitus, type 2 , glucose , insulin

Diabetes November 1997, Vol.46, 1786-1791. doi:https://doi.org/10.2337/diab.46.11.1786

Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides

A O Schaffhauser; A Stricker-Krongrad; L Brunner; F Cumin; C Gerald; S Whitebread; L Criscione; K G Hofbauer

Abstract

View articletitled, Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides

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Topics: eating , neuropeptide y , oligodeoxyribonucleotides, antisense

Diabetes November 1997, Vol.46, 1792-1798. doi:https://doi.org/10.2337/diab.46.11.1792

Interstitial Muscle Insulin and Glucose Levels in Normal and Insulin-Resistant Zucker Rats

Agneta Holmäng; Kazuo Mimura; Per Björntorp; Peter Lsönroth

Abstract

View articletitled, Interstitial Muscle Insulin and Glucose Levels in Normal and Insulin-Resistant Zucker Rats

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Topics: glucose , insulin , rats, zucker

Diabetes November 1997, Vol.46, 1799-1804. doi:https://doi.org/10.2337/diab.46.11.1799

Insulin-Independent Acute Restoration of Euglycemia Normalizes the Impaired Glucose Clearance During Exercise in Diabetic Dogs

Simon J Fisher; Michael Lekas; Z Qing Shi; Debra Bilinski; George Carvalho; Adria Giacca; Mladen Vranic

Abstract

View articletitled, Insulin-Independent Acute Restoration of Euglycemia Normalizes the Impaired Glucose Clearance During Exercise in Diabetic Dogs

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Topics: blood glucose normal , dog, domestic , drug clearance , glucose , insulin

Diabetes November 1997, Vol.46, 1805-1812. doi:https://doi.org/10.2337/diab.46.11.1805

Reassessment of Glucose Effectiveness and Insulin Sensitivity From Minimal Model Analysis: A Theoretical Evaluation of the Single-Compartment Glucose Distribution Assumption

Ta-Chen Ni; Marilyn Ader; Richard N Bergman

Abstract

View articletitled, Reassessment of Glucose Effectiveness and Insulin Sensitivity From Minimal Model Analysis: A Theoretical Evaluation of the Single-Compartment Glucose Distribution Assumption

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Topics: glucose , insulin sensitivity

Diabetes November 1997, Vol.46, 1813-1821. doi:https://doi.org/10.2337/diab.46.11.1813

Evidence of an Increased Number of Type IIb Muscle Fibers in Insulin-Resistant First-Degree Relatives of Patients with NIDDM

Birgit Nyholm; Zhuqing Qu; Andreas Kaal; Steen Bønnelykke Pedersen; Claus Højbjerg Gravholt; Jesper Løvind Andersen; Bengt Saltin; Ole Schmitz

Abstract

View articletitled, Evidence of an Increased Number of Type IIb Muscle Fibers in Insulin-Resistant First-Degree Relatives of Patients with NIDDM

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Topics: diabetes mellitus, type 2 , insulin , muscle fibers

Diabetes November 1997, Vol.46, 1822-1828. doi:https://doi.org/10.2337/diab.46.11.1822

Clustering of Long-Term Complications in Families With Diabetes in the Diabetes Control and Complications Trial

The Diabetes Control and Complications Trial Research Group

View articletitled, Clustering of Long-Term Complications in Families With Diabetes in the Diabetes Control and Complications Trial

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Topics: dcct trial

Diabetes November 1997, Vol.46, 1829-1839. doi:https://doi.org/10.2337/diab.46.11.1829

Impairment of Cerebrovascular Reactivity in Long-Term Type 1 Diabetes

Béla Fülesdi; Martien Limburg; Dániel Bereczki; Robert P J Michels; Gyula Neuwirth; Dink Legemate; Attila Valikovics; László Csiba

Abstract

View articletitled, Impairment of Cerebrovascular Reactivity in Long-Term Type 1 Diabetes

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Topics: diabetes mellitus, type 1

Diabetes November 1997, Vol.46, 1840-1845. doi:https://doi.org/10.2337/diab.46.11.1840

Aerobic Exercise Capacity Remains Normal Despite Impaired Endothelial Function in the Micro- and Macrocirculation of Physically Active IDDM Patients

Aristidis Veves; Rola Saouaf; Valerie M Donaghue; Catherine A Mullooly; Joy A Kistler; John M Giurini; Edward S Horton; Roger A Fielding

Abstract

View articletitled, Aerobic Exercise Capacity Remains Normal Despite Impaired Endothelial Function in the Micro- and Macrocirculation of Physically Active IDDM Patients

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Topics: diabetes mellitus, type 1 , endothelium , microbiology procedures

Diabetes November 1997, Vol.46, 1846-1852. doi:https://doi.org/10.2337/diab.46.11.1846

Defective Plasma Antioxidant Defenses and Enhanced Susceptibility to Lipid Peroxidation in Uncomplicated IDDM

Stefano A Santini; Giampiero Marra; Bruno Giardina; Patrizia Cotroneo; Alvaro Mordente; Giuseppe E Martorana; Andrea Manto; Giovanni Ghirlanda

Abstract

View articletitled, Defective Plasma Antioxidant Defenses and Enhanced Susceptibility to Lipid Peroxidation in Uncomplicated IDDM

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Topics: antioxidants , diabetes mellitus, type 1 , lipid peroxidation , plasma

Diabetes November 1997, Vol.46, 1853-1858. doi:https://doi.org/10.2337/diab.46.11.1853

The Blood Contribution to Early Myocardial Reperfusion Injury Is Amplified in Diabetes

Paul F McDonagh; Jason Y Hokama; Jack G Copeland; James M Reynolds

Abstract

View articletitled, The Blood Contribution to Early Myocardial Reperfusion Injury Is Amplified in Diabetes

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Topics: myocardial reperfusion injury

Diabetes November 1997, Vol.46, 1859-1867. doi:https://doi.org/10.2337/diab.46.11.1859

Renal and Ocular Hemodynamic Effects of Insulin

Leopold Schmetterer; Markus Müller; Peter Fasching; Carmen Diepolder; Antje Gallenkamp; Gabriele Zanaschka; Oliver Findl; Karin Strenn; Christa Mensik; Edda Tschernko; Hans-Georg Eichler; Michael Wolzt

Abstract

View articletitled, Renal and Ocular Hemodynamic Effects of Insulin

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Topics: hemodynamics , insulin , kidney

Diabetes November 1997, Vol.46, 1868-1874. doi:https://doi.org/10.2337/diab.46.11.1868

Immunohistochemical Quantification of Heparan Sulfate Proteoglycan and Collagen IV in Skeletal Muscle Capillary Basement Membranes of Patients With Diabetic Nephropathy

Hiroki Yokoyama; Poul E Høyer; Pernille M Hansen; Jacob van den Born; Tonny Jensen; Jo H M Berden; Torsten Deckert; Charly Garbarsch

Abstract

View articletitled, Immunohistochemical Quantification of Heparan Sulfate Proteoglycan and Collagen IV in Skeletal Muscle Capillary Basement Membranes of Patients With Diabetic Nephropathy

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Topics: basement membrane , blood capillaries , collagen type iv , diabetic nephropathy , heparan sulfate proteoglycans

Diabetes November 1997, Vol.46, 1875-1880. doi:https://doi.org/10.2337/diab.46.11.1875

Upregulation of Mesangial Growth Factor and Extracellular Matrix Synthesis by Advanced Glycation End Products Via a Receptor-Mediated Mechanism

Giuseppe Pugliese; Flavia Pricci; Giulio Romeo; Francesco Pugliese; Paolo Mené; Stefano Giannini; Barbara Cresci; Gianna Galli; Carlo M Rotella; Helen Vlassara; Umberto Di Mario

Abstract

View articletitled, Upregulation of Mesangial Growth Factor and Extracellular Matrix Synthesis by Advanced Glycation End Products Via a Receptor-Mediated Mechanism

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Topics: extracellular matrix , glycosylation end products, advanced , growth factor , up-regulation (physiology)

Diabetes November 1997, Vol.46, 1881-1887. doi:https://doi.org/10.2337/diab.46.11.1881

The Effect of HLA-B Allele on the IDDM Risk Defined by DRB104 Subtypes and DQB10302

Sergei Nejentsev; Helena Reijonen; Bela Adojaan; Liliya Kovalchuk; Arthur Sochnevs; Eugene I Schwartz; Hans K Åkerblom; Jorma Ilonen

Abstract

View articletitled, The Effect of HLA-B Allele on the IDDM Risk Defined by DRB1*04 Subtypes and DQB1*0302

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Topics: alleles , diabetes mellitus, type 1 , hla-b antigens

Diabetes November 1997, Vol.46, 1888-1892. doi:https://doi.org/10.2337/diab.46.11.1888

Association of HLA-DR, DQ Genotype With Different β-Cell Functions at IDDM Diagnosis in Japanese Children

Shigetaka Sugihara; Tateo Sakamaki; Susumu Konda; Atsushi Murata; Kunio Wataki; Yasuyuki Kobayashi; Kanshi Minamitani; Shigeki Miyamoto; Nozomu Sasaki; Hiroo Niimi

Abstract

View articletitled, Association of HLA-DR, DQ Genotype With Different β-Cell Functions at IDDM Diagnosis in Japanese Children

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Topics: child , diabetes mellitus, type 1 , genotype , hla-dr antigens

Diabetes November 1997, Vol.46, 1893-1897. doi:https://doi.org/10.2337/diab.46.11.1893

Brief Genetics Reports

The Gln²²³ Arg and Lys⁶⁵⁶ Asn Polymorphisms in the Human Leptin Receptor Do Not Associate With Traits Related to Obesity

Kristi Silver; Jeremy Walston; Wendy K Chung; Flora Yao; Vipul V Parikh; Ross Andersen; Lawrence J Cheskin; Dariush Elahi; Denis Muller; Rudolph L Leibel; Alan R Shuldiner

View articletitled, The Gln223 Arg and Lys656 Asn Polymorphisms in the Human Leptin Receptor Do Not Associate With Traits Related to Obesity

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Topics: leptin , obesity , polymorphism

Diabetes November 1997, Vol.46, 1898-1900. doi:https://doi.org/10.2337/diab.46.11.1898

Dominant Transmission of Insulin Resistance in a Type A Family Resulting From a Heterozygous Nonsense Mutation in the Insulin Receptor Gene and Associated With Decreased mRNA Level and Insulin Binding Sites

Jocelyne Magré; Christina Karayanni; Charalambos G Hadjiathanasiou; Christèle Desbois-Mouthon; Muriel Meier; Corinne Vigouroux; Christos Stavrinadis; Constantinos Sinaniotis; Martine Caron; Jacqueline Capeau

View articletitled, Dominant Transmission of Insulin Resistance in a Type A Family Resulting From a Heterozygous Nonsense Mutation in the Insulin Receptor Gene and Associated With Decreased mRNA Level and Insulin Binding Sites

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Topics: genes , heterozygote , insulin binding , insulin receptor , insulin resistance

Diabetes November 1997, Vol.46, 1901-1903. doi:https://doi.org/10.2337/diab.46.11.1901

No Coding Mutations Are Detected in the Peroxisome Proliferator-Activated Receptor-γ Gene in Japanese Patients with Lipoatrophic Diabetes

Hideki Okazawa; Hiroyuki Mori; Yoshikazu Tamori; Satoshi Araki; Toshiharu Niki; Jiro Masugi; Masatoshi Kawanishi; Takanori Kubota; Hiroaki Shinoda; Masato Kasuga

View articletitled, No Coding Mutations Are Detected in the Peroxisome Proliferator-Activated Receptor-γ Gene in Japanese Patients with Lipoatrophic Diabetes

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Topics: diabetes mellitus, lipoatrophic , genes , mutation , peroxisome

Diabetes November 1997, Vol.46, 1904-1906. doi:https://doi.org/10.2337/diab.46.11.1904

Rapid Publications

Progressive Islet Graft Failure Occurs Significantly Earlier in Autoantibody-Positive Than in Autoantibody-Negative IDDM Recipients of Intrahepatic Islet Allografts

Clemens Jaeger; Mathias D Brendel; Bernhard J Hering; Michael Eckhard; Reinhard G Bretzel

Abstract

View articletitled, Progressive Islet Graft Failure Occurs Significantly Earlier in Autoantibody-Positive Than in Autoantibody-Negative IDDM Recipients of Intrahepatic Islet Allografts

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Topics: allografting , autoantibodies , diabetes mellitus, type 1 , tissue transplants

Diabetes November 1997, Vol.46, 1907-1910. doi:https://doi.org/10.2337/diab.46.11.1907

Central Leptin Stimulates Corticosterone Secretion at the Onset of the Dark Phase

Gertjan van Dijk; Jamie C K Donahey; Todd E Thiele; Anton J W Scheurink; Anton B Steffens; Charles W Wilkinson; Renata Tenenbaum; L Arthur Campfield; Paul Burn; Randy J Seeley; Stephen C Woods

Abstract

View articletitled, Central Leptin Stimulates Corticosterone Secretion at the Onset of the Dark Phase

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Topics: bodily secretions , corticosterone , leptin

Diabetes November 1997, Vol.46, 1911-1914. doi:https://doi.org/10.2337/diab.46.11.1911

Nitric Oxide Stimulates Skeletal Muscle Glucose Transport Through a Calcium/Contraction– and Phosphatidylinositol-3-Kinase–Independent Pathway

Garret J Etgen, Jr; David A Fryburg; E Michael Gibbs

Abstract

View articletitled, Nitric Oxide Stimulates Skeletal Muscle Glucose Transport Through a Calcium/Contraction– and Phosphatidylinositol-3-Kinase–Independent Pathway

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Topics: 1-phosphatidylinositol 3-kinase , calcium , glucose transport , nitric oxide , skeletal muscles

Diabetes November 1997, Vol.46, 1915-1919. doi:https://doi.org/10.2337/diab.46.11.1915

Erratum

View articletitled, Erratum

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Diabetes November 1997, Vol.46, 1920. doi:https://doi.org/10.2337/diab.46.11.1920

SI Units Table

TABLE 1—Système International (SI) units for plasma, serum, or blood concentrations

View articletitled, TABLE 1—Système International (SI) units for plasma, serum, or blood concentrations

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Topics: plasma

Diabetes November 1997, Vol.46, 1921. doi:https://doi.org/10.2337/diab.46.11.1921

Organization Section

View articletitled, Organization Section

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Diabetes November 1997, Vol.46, 1922. doi:https://doi.org/10.2337/diab.46.11.1922

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