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1996 Presidential Address

Hypatia: Change, Limits, and Interconnectedness

Frank Vinicor

View articletitled, Hypatia: Change, Limits, and Interconnectedness

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Diabetes December 1997, Vol.46, 1923-1927. doi:https://doi.org/10.2337/diab.46.12.1923

Perspectives in Diabetes

Augmentation of Insulin Release by Glucose in the Absence of Extracellular Ca²⁺: New Insights Into Stimulus-Secretion Coupling

Mitsuhisa Komatsu; Thomas Schermerhorn; Mitsuhiko Noda; Susanne G Straub; Toru Aizawa; Geoffrey W G Sharp

Abstract

View articletitled, Augmentation of Insulin Release by Glucose in the Absence of Extracellular Ca2+: New Insights Into Stimulus-Secretion Coupling

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Topics: bodily secretions , glucose , insulin

Diabetes December 1997, Vol.46, 1928-1938. doi:https://doi.org/10.2337/diab.46.12.1928

Original Articles

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

Johannes B Prins; Carola U Niesler; Clay M Winterford; Nicholas A Bright; Kenneth Siddle; Stephen O'Rahilly; Neal I Walker; Donald P Cameron

Abstract

View articletitled, Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

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Topics: apoptosis , tumor necrosis

Diabetes December 1997, Vol.46, 1939-1944. doi:https://doi.org/10.2337/diab.46.12.1939

Regulation of Hepatic Glutaminase in the Streptozotocin-Induced Diabetic Rat

Stephen A Squires; H Stephen Ewart; Colin McCarthy; Margaret E Brosnan; John T Brosnan

Abstract

View articletitled, Regulation of Hepatic Glutaminase in the Streptozotocin-Induced Diabetic Rat

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Topics: glutaminase , streptozocin

Diabetes December 1997, Vol.46, 1945-1949. doi:https://doi.org/10.2337/diab.46.12.1945

Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action

Carla RO Carvalho; Ana Claudia P Thirone; Jose A R Gontijo; Licio A Velloso; Mario J A Saad

Abstract

View articletitled, Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action

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Topics: bradykinin , captopril , insulin , losartan

Diabetes December 1997, Vol.46, 1950-1957. doi:https://doi.org/10.2337/diab.46.12.1950

Sensitization to Insulin Induced by β,β′-Methyl-Substituted Hexadecanedioic Acid (MEDICA 16) in Obese Zucker Rats In Vivo

Nina Mayorek; Bella Kalderon; Etty Itach; Jacob Bar-Tana

Abstract

View articletitled, Sensitization to Insulin Induced by β,β′-Methyl-Substituted Hexadecanedioic Acid (MEDICA 16) in Obese Zucker Rats In Vivo

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Topics: insulin , obesity , rats, zucker , sensitization

Diabetes December 1997, Vol.46, 1958-1964. doi:https://doi.org/10.2337/diab.46.12.1958

Effect of Insulin on GLUT4 Cell Surface Content and Turnover Rate in Human Skeletal Muscle as Measured by the Exofacial Bis-Mannose Photolabeling Technique

Sten Lund; Geoffrey D Holman; Juleen R Zierath; Jorge Rincon; Lorraine A Nolte; Avril E Clark; Ole Schmitz; Oluf Pedersen; Harriet Wallberg-Henriksson

Abstract

View articletitled, Effect of Insulin on GLUT4 Cell Surface Content and Turnover Rate in Human Skeletal Muscle as Measured by the Exofacial Bis-Mannose Photolabeling Technique

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Topics: insulin , mannose , skeletal muscles

Diabetes December 1997, Vol.46, 1965-1969. doi:https://doi.org/10.2337/diab.46.12.1965

Reduction in Diabetes Incidence in an I-A^g7 Transgenic Nonobese Diabetic Mouse Line

Diane K Wherrett; Steven M Singer; Hugh O McDevitt

Abstract

View articletitled, Reduction in Diabetes Incidence in an I-Ag7 Transgenic Nonobese Diabetic Mouse Line

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Topics: animals, transgenic , mice, inbred nod

Diabetes December 1997, Vol.46, 1970-1974. doi:https://doi.org/10.2337/diab.46.12.1970

Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

Marina Cetkovic-Cvrlje; Ivan C Gerling; Andrew Muir; Mark A Atkinson; John F Elliott; Edward H Leiter

Abstract

View articletitled, Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

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Topics: antigens , mice

Diabetes December 1997, Vol.46, 1975-1982. doi:https://doi.org/10.2337/diab.46.12.1975

Long-Term Function (6 Years) of Islet Allografts in Type 1 Diabetes

Rodolfo Alejandro; Roger Lehmann; Camillo Ricordi; Norma S Kenyon; M Clara Angelico; George Burke; Violet Esquenazi; Jose Nery; Arthur E Betancourt; Shen S Kong; Joshua Miller; Daniel H Mintz

Abstract

View articletitled, Long-Term Function (6 Years) of Islet Allografts in Type 1 Diabetes

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Topics: allografting , diabetes mellitus, type 1

Diabetes December 1997, Vol.46, 1983-1989. doi:https://doi.org/10.2337/diab.46.12.1983

The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects

Leena Mykkänen; Steven M Haffner; C Nick Hales; Tapani Rönnemaa; Markku Laakso

Abstract

View articletitled, The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects

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Topics: blood glucose normal , insulin , insulin sensitivity , proinsulin

Diabetes December 1997, Vol.46, 1990-1995. doi:https://doi.org/10.2337/diab.46.12.1990

Oscillations in Activities of Enzymes in Pancreatic Islet Subcellular Fractions Induced by Physiological Concentrations of Effectors

Michael J MacDonald; Hussam Al-Masri; Muriel Jumelle-Laclau; Meredith O Cruz

Abstract

View articletitled, Oscillations in Activities of Enzymes in Pancreatic Islet Subcellular Fractions Induced by Physiological Concentrations of Effectors

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Topics: endocrine pancreas , enzymes , subcellular fractions

Diabetes December 1997, Vol.46, 1996-2001. doi:https://doi.org/10.2337/diab.46.12.1996

Localization and Functional Role of Synaptotagmin III in Insulin Secretory Vesicles in Pancreatic β-Cells

Masanari Mizuta; Takeshi Kurose; Takashi Miki; Yoko Shoji-Kasai; Masami Takahashi; Susumu Seino; Shigeru Matsukura

Abstract

View articletitled, Localization and Functional Role of Synaptotagmin III in Insulin Secretory Vesicles in Pancreatic β-Cells

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Topics: insulin , pancreas , secretory vesicles

Diabetes December 1997, Vol.46, 2002-2006. doi:https://doi.org/10.2337/diab.46.12.2002

Assessment of Hepatic Sensitivity to Glucagon in NIDDM: Use as a Tool to Estimate the Contribution of the Indirect Pathway to Nocturnal Glycogen Synthesis

Michael F Nielsen; Steven Wise; Sean F Dinneen; W Frederick Schwenk; Ananda Basil; Robert A Rizza

Abstract

View articletitled, Assessment of Hepatic Sensitivity to Glucagon in NIDDM: Use as a Tool to Estimate the Contribution of the Indirect Pathway to Nocturnal Glycogen Synthesis

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Topics: diabetes mellitus, type 2 , glucagon , glycogen synthesis , night time

Diabetes December 1997, Vol.46, 2007-2016. doi:https://doi.org/10.2337/diab.46.12.2007

Effects of Insulin on Blood Flow and Volume in Skeletal Muscle of Patients With IDDM: Studies Using [¹⁵O]H₂O, [¹⁵O]CO, and Positron Emission Tomography

Maria Raitakari; Pirjo Nuutila; Juhani Knuuti; Olli T Raitakari; Hanna Laine; Ulla Ruotsalainen; Olli Kirvelä; Teemu O Takala; Hidehiro Iida; Hannele Yki-Järvinen

Abstract

View articletitled, Effects of Insulin on Blood Flow and Volume in Skeletal Muscle of Patients With IDDM: Studies Using [15O]H2O, [15O]CO, and Positron Emission Tomography

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Topics: diabetes mellitus, type 1 , insulin , positron-emission tomography , skeletal muscles , vascular flow

Diabetes December 1997, Vol.46, 2017-2021. doi:https://doi.org/10.2337/diab.46.12.2017

Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

Nicholas D Oakes; Kim S Bell; Stuart M Furler; Souad Camilleri; Asish K Saha; Neil B Ruderman; Donald J Chisholm; Edward W Kraegen

Abstract

View articletitled, Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

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Topics: acyl coenzyme a , diet , dietary fats , glucose uptake , insulin

Diabetes December 1997, Vol.46, 2022-2028. doi:https://doi.org/10.2337/diab.46.12.2022

Leptin Sensitivity in Nonobese Glucagon-Like Peptide I Receptor −/− Mice

Louise A Scrocchi; Theodore J Brown; Daniel J Drucker

Abstract

View articletitled, Leptin Sensitivity in Nonobese Glucagon-Like Peptide I Receptor −/− Mice

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Topics: glucagon , leptin , mice , peptides

Diabetes December 1997, Vol.46, 2029-2034. doi:https://doi.org/10.2337/diab.46.12.2029

Leptin Gene Expression Increases With Age Independent of Increasing Adiposity in Rats

Hua Li; Michael Matheny; Margery Nicolson; Nihal Türner; Philip J Scarpace

Abstract

View articletitled, Leptin Gene Expression Increases With Age Independent of Increasing Adiposity in Rats

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Topics: gene expression , leptin , obesity , rats

Diabetes December 1997, Vol.46, 2035-2039. doi:https://doi.org/10.2337/diab.46.12.2035

Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

Joseph C Dunbar; Yuange Hu; Huiqing Lu

Abstract

View articletitled, Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

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Topics: blood pressure , kidney , leptin , rats , sympathetic nerve

Diabetes December 1997, Vol.46, 2040-2043. doi:https://doi.org/10.2337/diab.46.12.2040

Method of Insulin Administration Has No Effect on Insulin Sensitivity Estimates From the Insulin-Modified Minimal Model Protocol

Mohammed F Saad; Garry M Steil; Maggy Riad-Gabriel; Arshad Khan; Alok Sharma; Rima Boyadjian; Sujata D Jinagouda; Richard N Bergman

Abstract

View articletitled, Method of Insulin Administration Has No Effect on Insulin Sensitivity Estimates From the Insulin-Modified Minimal Model Protocol

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Topics: insulin , insulin administration , insulin sensitivity

Diabetes December 1997, Vol.46, 2044-2048. doi:https://doi.org/10.2337/diab.46.12.2044

Induction of Renal Kallikrein and Renin Gene Expression by Insulin and IGF-I in the Diabetic Rat

Ayad A Jaffa; Carlos Vio; Victoria Velarde; Derek LeRoith; Ronald K Mayfield

Abstract

View articletitled, Induction of Renal Kallikrein and Renin Gene Expression by Insulin and IGF-I in the Diabetic Rat

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Topics: gene expression , insulin , insulin-like growth factor i , kidney , kininogenase

Diabetes December 1997, Vol.46, 2049-2056. doi:https://doi.org/10.2337/diab.46.12.2049

Impaired Molecular Regenerative Responses in Sensory Neurones of Diabetic Rats: Gene Expression Changes in Dorsal Root Ganglia After Sciatic Nerve Crush

L Mohiuddin; D R Tomlinson

Abstract

View articletitled, Impaired Molecular Regenerative Responses in Sensory Neurones of Diabetic Rats: Gene Expression Changes in Dorsal Root Ganglia After Sciatic Nerve Crush

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Topics: ganglia, spinal , gene expression , rats , sciatic nerve

Diabetes December 1997, Vol.46, 2057-2062. doi:https://doi.org/10.2337/diab.46.12.2057

Hyperinsulinemia and Abdominal Obesity Affect the Expression of Hypertriglyceridemia in Heterozygous Familial Lipoprotein Lipase Deficiency

Pierre Julien; Marie-Claude Void; Daniel Gaudet; Claude Gagné; Georges Lévesque; Jean-Pierre Després; François Cadelis; Louis Daniel Brun; André Nadeau; M R Ven Murthy

Abstract

View articletitled, Hyperinsulinemia and Abdominal Obesity Affect the Expression of Hypertriglyceridemia in Heterozygous Familial Lipoprotein Lipase Deficiency

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Topics: familial lipoprotein lipase deficiency , heterozygote , hyperinsulinism , hypertriglyceridemia , obesity, abdominal

Diabetes December 1997, Vol.46, 2063-2068. doi:https://doi.org/10.2337/diab.46.12.2063

Altered Platelet Membrane Dynamic Properties in Type 1 Diabetes

Laura Mazzanti; Rosa A Rabini; Paolo Fumelli; Daniela Martarelli; Roberto Staffolani; Eleonora Salvolini; Giovanna Curatola

Abstract

View articletitled, Altered Platelet Membrane Dynamic Properties in Type 1 Diabetes

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Topics: blood platelets , diabetes mellitus, type 1 , tissue membrane

Diabetes December 1997, Vol.46, 2069-2074. doi:https://doi.org/10.2337/diab.46.12.2069

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

Hikaru Sugimoto; Kenichi Shikata; Kyoji Hirata; Kenji Akiyama; Mitsuhiro Matsuda; Masahiko Kushiro; Yasushi Shikata; Nobuyuki Miyatake; Masayuki Miyasaka; Hirofumi Makino

Abstract

View articletitled, Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

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Topics: intercellular adhesion molecule 1 , kidney glomerulus , up-regulation (physiology)

Diabetes December 1997, Vol.46, 2075-2081. doi:https://doi.org/10.2337/diab.46.12.2075

Cholesteryl Ester Transfer Protein Gene Polymorphism Is a Determinant of HDL Cholesterol and of the Lipoprotein Response to a Lipid-Lowering Diet in Type 1 Diabetes

Robin P F Dullaart; Klaas Hoogenberg; Stephen C Riemens; Johanna E M Groener; Arie van Tol; Wim J Sluiter; Ben K Stulp

Abstract

View articletitled, Cholesteryl Ester Transfer Protein Gene Polymorphism Is a Determinant of HDL Cholesterol and of the Lipoprotein Response to a Lipid-Lowering Diet in Type 1 Diabetes

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Topics: cholesterol ester transfer proteins , diabetes mellitus, type 1 , diet , genes , high density lipoprotein cholesterol

Diabetes December 1997, Vol.46, 2082-2087. doi:https://doi.org/10.2337/diab.46.12.2082

Pyruvate Improves Deleterious Effects of High Glucose on Activation of Pentose Phosphate Pathway and Glutathione Redox Cycle in Endothelial Cells

Atsunori Kashiwagi; Yoshihiko Nishio; Takayuki Asahina; Motoyoshi Ikebuchi; Natsuki Harada; Yasushi Tanaka; Noriko Takahara; Hideki Taki; Toshiyuki Obata; Hideki Hidaka; Yukikazu Saeki; Ryuichi Kikkawa

Abstract

View articletitled, Pyruvate Improves Deleterious Effects of High Glucose on Activation of Pentose Phosphate Pathway and Glutathione Redox Cycle in Endothelial Cells

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Topics: endothelial cells , glucose , glutathione , oxidation-reduction , pentose phosphate pathway

Diabetes December 1997, Vol.46, 2088-2095. doi:https://doi.org/10.2337/diab.46.12.2088

Circulating Vascular Cell Adhesion Molecule-1 (VCAM-1) in Atherosclerotic NIDDM Patients

Michio Otsuki; Kunihiko Hashimoto; Yasuhiko Morimoto; Tadamitsu Kishimoto; Soji Kasayama

Abstract

View articletitled, Circulating Vascular Cell Adhesion Molecule-1 (VCAM-1) in Atherosclerotic NIDDM Patients

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Topics: diabetes mellitus, type 2 , vascular cell adhesion molecule-1

Diabetes December 1997, Vol.46, 2096-2101. doi:https://doi.org/10.2337/diab.46.12.2096

Brief Genetics Reports

Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Arterial Wall Thickening and Myocardial Infarction Risk in NIDDM

Katsumi Arai; Yoshimitsu Yamasaki; Yoshitaka Kajimoto; Hirotaka Watada; Yutaka Umayahara; Mineo Kodama; Ken'ya Sakamoto; Masatsugu Hori

View articletitled, Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Arterial Wall Thickening and Myocardial Infarction Risk in NIDDM

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Topics: diabetes mellitus, type 2 , genes , methylenetetrahydrofolate reductase (nadph2) , myocardial infarction , polymorphism

Diabetes December 1997, Vol.46, 2102-2104. doi:https://doi.org/10.2337/diab.46.12.2102

Uncoupling Protein 2 Region on Chromosome 11q13 Is not Linked to Markers of Obesity in Familial Type 2 Diabetes

Steven C Elbein; Mark Leppert; Sandra Hasstedt

View articletitled, Uncoupling Protein 2 Region on Chromosome 11q13 Is not Linked to Markers of Obesity in Familial Type 2 Diabetes

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Topics: chromosomes , diabetes mellitus, type 2 , obesity , uncoupling protein 2

Diabetes December 1997, Vol.46, 2105-2107. doi:https://doi.org/10.2337/diab.46.12.2105

An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-1α Gene (Maturity-Onset Diabetes of the Young)

Philippe Boutin; Jean Claude Chévre; El Habib Hani; Ramon Gomis; Victor C Pardini; Pierre-Jean Guillausseau; Martine Vaxillaire; Gilberto Velho; Philippe Froguel

View articletitled, An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-1α Gene (Maturity-Onset Diabetes of the Young)

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Topics: genes , hepatocytes , maturity onset diabetes mellitus in young , molecular conformation , mutation

Diabetes December 1997, Vol.46, 2108-2109. doi:https://doi.org/10.2337/diab.46.12.2108

Rapid Publications

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

Anna Krook; Yuichi Kawano; Xiao Mei Song; Suad Efendić; Richard A Roth; Harriet Wallberg-Henriksson; Juleen R Zierath

Abstract

View articletitled, Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

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Topics: glucose tolerance , glucose transport , insulin , phosphotransferases , proto-oncogene proteins c-akt

Diabetes December 1997, Vol.46, 2110-2114. doi:https://doi.org/10.2337/diab.46.12.2110

Thiazolidinediones Downregulate Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes

Shogo Kurebayashi; Takahisa Hirose; Yoshihiro Miyashita; Soji Kasayama; Tadamitsu Kishimoto

Abstract

View articletitled, Thiazolidinediones Downregulate Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes

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Topics: adipocytes , gene expression , stearoyl-coa desaturase , thiazolidinedione

Diabetes December 1997, Vol.46, 2115-2118. doi:https://doi.org/10.2337/diab.46.12.2115

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

Michael W Schwartz; Randy J Seeley; Stephen C Woods; David S Weigle; L Arthur Campfield; Paul Burn; Denis G Baskin

Abstract

View articletitled, Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

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Topics: hypothalamus , leptin , nucleus infundibularis hypothalami , pro-opiomelanocortin , rna, messenger

Diabetes December 1997, Vol.46, 2119-2123. doi:https://doi.org/10.2337/diab.46.12.2119

Tribute

Harold Rifkin, MD 1916–1997

Gerald Bernstein, MD

View articletitled, Harold Rifkin, MD 1916–1997

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Diabetes December 1997, Vol.46, 2124-2126. doi:https://doi.org/10.2337/diab.46.12.2124

Organization Section

Other Events

View articletitled, Other Events

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Diabetes December 1997, Vol.46, 2127. doi:https://doi.org/10.2337/diab.46.12.2127

SI Units Table

Système International (SI) units for plasma, serum, or blood concentrations

View articletitled, Système International (SI) units for plasma, serum, or blood concentrations

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Topics: plasma

Diabetes December 1997, Vol.46, 2128. doi:https://doi.org/10.2337/diab.46.12.2128

1997 Subject And Author Indexes

View articletitled, 1997 Subject And Author Indexes

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Diabetes December 1997, Vol.46, 2129-2138. doi:https://doi.org/10.2337/diab.46.12.2129

Issues

1996 Presidential Address

Perspectives in Diabetes

Original Articles

Brief Genetics Reports

Rapid Publications

Tribute

Organization Section

SI Units Table

1997 Subject And Author Indexes

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