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Perspectives in Diabetes

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

John C Lawrence, Jr; Peter J Roach

Abstracts

View articletitled, New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

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Topics: glycogen (starch) synthase , insulin

Diabetes April 1997, Vol.46, 541-547. doi:https://doi.org/10.2337/diab.46.4.541

Original Articles

Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of its Analogs—Lys^B28Pro^B29-Human Insulin and Asp^B10Lys^B28Pro^B29-Human Insulin—Assessed in a Conscious Pig Model

Jerry M Radziuk; Jill C Davies; W Susan Pye; James E Shields; Richard D DiMarchi; Ronald E Chance

Abstracts

View articletitled, Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of its Analogs—LysB28ProB29-Human Insulin and AspB10LysB28ProB29-Human Insulin—Assessed in a Conscious Pig Model

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Topics: biological availability , insulin

Diabetes April 1997, Vol.46, 548-556. doi:https://doi.org/10.2337/diab.46.4.548

Immunological Aspects of Nutritional Diabetes Prevention in NOD Mice: A Pilot Study for the Cow's Milk–Based IDDM Prevention Trial

Wolfram Karges; Denise Hammond-McKibben; Roy K Cheung; Marc Visconti; Noriko Shibuya; Don Kemp; Hans-Michael Dosch

Abstracts

View articletitled, Immunological Aspects of Nutritional Diabetes Prevention in NOD Mice: A Pilot Study for the Cow's Milk–Based IDDM Prevention Trial

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Topics: cow's milk , diabetes mellitus, type 1 , diabetes prevention , mice, inbred nod

Diabetes April 1997, Vol.46, 557-564. doi:https://doi.org/10.2337/diab.46.4.557

Combined Analysis and Single-Step Detection of GAD65 and IA2 Autoantibodies in IDDM Can Replace the Histochemical Islet Cell Antibody Test

Uta Wiest-Ladenburger; Ralf Hartmann; Ulrike Hartmann; Kerstin Berling; Bernhard O Böhm; Wiltrud Richter

Abstracts

View articletitled, Combined Analysis and Single-Step Detection of GAD65 and IA2 Autoantibodies in IDDM Can Replace the Histochemical Islet Cell Antibody Test

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Topics: antibodies , autoantibodies , diabetes mellitus, type 1 , endocrine pancreas

Diabetes April 1997, Vol.46, 565-571. doi:https://doi.org/10.2337/diab.46.4.565

Association Between αβTCR⁺CD4⁻CD8⁻ T-Cell Deficiency and IDDM in NOD/Lt Mice

Alan G Baxter; Simon J Kinder; Kirsten J L Hammond; Roland Scollay; Dale I Godfrey

Abstracts

View articletitled, Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

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Topics: diabetes mellitus, type 1 , mice , t-lymphocyte deficiency

Diabetes April 1997, Vol.46, 572-582. doi:https://doi.org/10.2337/diab.46.4.572

Glutamate Decarboxylase–Reactive Peripheral Blood Lymphocytes From Patients With IDDM Express Gut-Specific Homing Receptor α₄β₇-Integrin

Johanna Paronen; Paula Klemetti; Jussi M Kantele; Erkki Savilahti; Jaakko Perheentupa; Hans K Åkerblom; Outi Vaarala

Abstracts

View articletitled, Glutamate Decarboxylase–Reactive Peripheral Blood Lymphocytes From Patients With IDDM Express Gut-Specific Homing Receptor α4β7-Integrin

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Topics: diabetes mellitus, type 1 , glutamate decarboxylase , integrins , lymphocytes

Diabetes April 1997, Vol.46, 583-588. doi:https://doi.org/10.2337/diab.46.4.583

Potential Mechanisms by Which Certain Foods Promote or Inhibit the Development of Spontaneous Diabetes in BB Rats: Dose, Timing, Early Effect on Islet Area, and Switch in Infiltrate From Th1 to Th2 Cells

Fraser W Scott; Heather E Cloutier; Rainer Kleemann; Ute Wöerz-Pagenstert; Paul Rowsell; H Wayne Modler; Hubert Kolb

Abstracts

View articletitled, Potential Mechanisms by Which Certain Foods Promote or Inhibit the Development of Spontaneous Diabetes in BB Rats: Dose, Timing, Early Effect on Islet Area, and Switch in Infiltrate From Th1 to Th2 Cells

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Topics: infiltrates , rats, inbred bb , th2 cells , diet , cytokine

Diabetes April 1997, Vol.46, 589-598. doi:https://doi.org/10.2337/diab.46.4.589

α-Cell Neogenesis in an Animal Model of IDDM

Lorraine A O'Reilly; Danling Gu; Nora Sarvetnick; Helena Edlund; Jenny M Phillips; Tony Fulford; Anne Cooke

Abstracts

View articletitled, α-Cell Neogenesis in an Animal Model of IDDM

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Topics: animal model , diabetes mellitus, type 1

Diabetes April 1997, Vol.46, 599-606. doi:https://doi.org/10.2337/diab.46.4.599

Elevated Islet Amyloid Pancreatic Polypeptide and Proinsulin in Lean Gestational Diabetes

A Kautzky-Willer; K Thomaseth; B Ludvik; P Nowotny; D Rabensteiner; W Waldhäusl; G Pacini; R Prager

Abstracts

View articletitled, Elevated Islet Amyloid Pancreatic Polypeptide and Proinsulin in Lean Gestational Diabetes

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Topics: amyloid , gestational diabetes , pancreatic polypeptide , proinsulin

Diabetes April 1997, Vol.46, 607-614. doi:https://doi.org/10.2337/diab.46.4.607

Protein Kinase A-Dependent Stimulation of Exocytosis in Mouse Pancreatic β-Cells by Glucose-Dependent Insulinotropic Polypeptide

Wei-Guang Ding; Jesper Gromada

Abstracts

View articletitled, Protein Kinase A-Dependent Stimulation of Exocytosis in Mouse Pancreatic β-Cells by Glucose-Dependent Insulinotropic Polypeptide

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Topics: exocytosis , glucose , mice , pancreas , protein kinase

Diabetes April 1997, Vol.46, 615-621. doi:https://doi.org/10.2337/diab.46.4.615

Diagnostic Heterogeneity of Diabetes in Lean Young Adults: Classification Based on Immunological and Genetic Parameters

Philippe Dussoix; Martine Vaxillaire; Patrick B Iynedjian; Jean-Marie Tiercy; Juan Ruiz; Giatgen A Spinas; Willy Berger; Gaston Zahnd; Philippe Froguel; Jacques Philippe

Abstracts

View articletitled, Diagnostic Heterogeneity of Diabetes in Lean Young Adults: Classification Based on Immunological and Genetic Parameters

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Topics: genetics , heterogeneity , young adult , maturity onset diabetes mellitus in young

Diabetes April 1997, Vol.46, 622-631. doi:https://doi.org/10.2337/diab.46.4.622

Effects of Pramlintide, an Analog of Human Amylin, on Plasma Glucose Profiles in Patients With IDDM: Results of a Multicenter Trial

Robert G Thomas; Janet Peterson; Alan Gottlieb; John Mullane

Abstracts

View articletitled, Effects of Pramlintide, an Analog of Human Amylin, on Plasma Glucose Profiles in Patients With IDDM: Results of a Multicenter Trial

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Topics: diabetes mellitus, type 1 , iapp gene , plasma glucose , pramlintide

Diabetes April 1997, Vol.46, 632-636. doi:https://doi.org/10.2337/diab.46.4.632

Acylation of Human Insulin With Palmitic Acid Extends the Time Action of Human Insulin in Diabetic Dogs

Sharon Myers; Fatima E Yakubu-Madus; William T Johnson; James E Baker; Tania S Cusick; Valerie K Williams; Frank C Tinsley; Aidas Kriauciunas; Joseph Manetta; Victor J Chen

Abstracts

View articletitled, Acylation of Human Insulin With Palmitic Acid Extends the Time Action of Human Insulin in Diabetic Dogs

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Topics: acylation , dog, domestic , insulin , palmitic acid

Diabetes April 1997, Vol.46, 637-642. doi:https://doi.org/10.2337/diab.46.4.637

Renal Glucose Production During Insulin-Induced Hypoglycemia

Eugenio Cersosimo; Patricia E Molina; Naji N Abumrad

Abstracts

View articletitled, Renal Glucose Production During Insulin-Induced Hypoglycemia

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Topics: glucose , hypoglycemia , insulin , kidney

Diabetes April 1997, Vol.46, 643-646. doi:https://doi.org/10.2337/diab.46.4.643

Aldose Reductase Inhibition Increases CNTF-Like Bioactivity and Protein in Sciatic Nerves From Galactose-Fed and Normal Rats

Andrew P Mizisin; Nigel A Calcutt; Peter S DiStefano; Ann Acheson; Frank M Longo

Abstracts

View articletitled, Aldose Reductase Inhibition Increases CNTF-Like Bioactivity and Protein in Sciatic Nerves From Galactose-Fed and Normal Rats

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Topics: aldehyde reductase , ciliary neurotrophic factor , galactose , rats , sciatic nerve

Diabetes April 1997, Vol.46, 647-652. doi:https://doi.org/10.2337/diab.46.4.647

Nitric Oxide and Ocular Blood Flow in Patients With IDDM

Leopold Schmetterer; Oliver Findl; Peter Fasching; Wolfgang Ferber; Karin Strenn; Helene Breiteneder; Hiltrud Adam; Hans-Georg Eichler; Michael Wolzt

Abstracts

View articletitled, Nitric Oxide and Ocular Blood Flow in Patients With IDDM

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Topics: diabetes mellitus, type 1 , nitric oxide , vascular flow

Diabetes April 1997, Vol.46, 653-658. doi:https://doi.org/10.2337/diab.46.4.653

Troglitazone Reduces Contraction by Inhibition of Vascular Smooth Muscle Cell Ca²⁺ Currents and Not Endothelial Nitric Oxide Production

Jianben Song; Mary F Walsh; Robert Igwe; Jeffrey L Ram; Mohamad Barazi; Ligia J Dominguez; James R Sowers

Abstracts

View articletitled, Troglitazone Reduces Contraction by Inhibition of Vascular Smooth Muscle Cell Ca2+ Currents and Not Endothelial Nitric Oxide Production

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Topics: endothelium , muscle, smooth, vascular , nitric oxide , troglitazone

Diabetes April 1997, Vol.46, 659-664. doi:https://doi.org/10.2337/diab.46.4.659

Hypertension as a Risk Factor for Diabetic Neuropathy: A Prospective Study

Kimberly Y-Z Forrest; Raelene E Maser; Georgia Pambianco; Dorothy J Becker; Trevor J Orchard

Abstracts

View articletitled, Hypertension as a Risk Factor for Diabetic Neuropathy: A Prospective Study

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Topics: diabetic neuropathies , hypertension

Diabetes April 1997, Vol.46, 665-670. doi:https://doi.org/10.2337/diab.46.4.665

Nitric Oxide Inhibition of Transforming Growth Factor-β and Collagen Synthesis in Mesangial Cells

Patricia A Craven; Rebecca K Studer; Jill Felder; Stephen Phillips; Frederick R DeRubertis

Abstracts

View articletitled, Nitric Oxide Inhibition of Transforming Growth Factor-β and Collagen Synthesis in Mesangial Cells

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Topics: collagen synthesis , mesangial cells , nitric oxide

Diabetes April 1997, Vol.46, 671-681. doi:https://doi.org/10.2337/diab.46.4.671

Effect of Polymorphism of Apolipoprotein E and Angiotensin-Converting Enzyme Genes on Arterial Wall Thickness

Kyoko Kogawa; Yoshiki Nishizawa; Masayuki Hosoi; Takahiko Kawagishi; Kiyoshi Maekawa; Tetsuo Shoji; Yasuhisa Okuno; Hirotoshi Morii

Abstracts

View articletitled, Effect of Polymorphism of Apolipoprotein E and Angiotensin-Converting Enzyme Genes on Arterial Wall Thickness

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Topics: ace gene , apolipoprotein e , polymorphism , carotid intima-media thickness

Diabetes April 1997, Vol.46, 682-687. doi:https://doi.org/10.2337/diab.46.4.682

Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians

El Habib Hani; Karine Clément; Gilberto Velho; Nathalie Vionnet; Jörg Hager; Anne Philippi; Christian Dina; Hiroshi Inoue; M Alan Permutt; Arnaud Basdevant; Michael North; Florence Demenais; Bernard Guy-Grand; Philippe Froguel

Abstracts

View articletitled, Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians

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Topics: diabetes mellitus, type 2 , genes , genetic research , obesity, morbid , sulfonylurea receptor

Diabetes April 1997, Vol.46, 688-694. doi:https://doi.org/10.2337/diab.46.4.688

Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene

Paul Denny; Christopher J Lord; Natasha J Hill; Juliet V Goy; Elaine R Levy; Patricia L Podolin; Laurence B Peterson; Linda S Wicker; John A Todd; Paul A Lyons

Abstracts

View articletitled, Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene

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Topics: diabetes mellitus, type 1 , genes , interleukin-2

Diabetes April 1997, Vol.46, 695-700. doi:https://doi.org/10.2337/diab.46.4.695

Predictors of Progression From Impaired Glucose Tolerance to NIDDM: An Analysis of Six Prospective Studies

Sharon L Edelstein; William C Knowler; Raymond P Bain; Reubin Andres; Elizabeth L Barrett-Connor; Gary K Dowse; Steven M Haffher; David J Pettitt; John D Sorkin; Denis C Muller; Veronica R Collins; Richard F Hamman

Abstracts

View articletitled, Predictors of Progression From Impaired Glucose Tolerance to NIDDM: An Analysis of Six Prospective Studies

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Topics: diabetes mellitus, type 2 , glucose intolerance

Diabetes April 1997, Vol.46, 701-710. doi:https://doi.org/10.2337/diab.46.4.701

Brief Genetics Report

The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Does Not Influence Insulin Sensitivity in Finnish Nondiabetic and NIDDM Subjects

Johanna Rissanen; Jussi Pihlajamäki; Sami Heikkinen; Päivi Kekäläinen; Johanna Kuusisto; Markku Laakso

Abstracts

View articletitled, The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Does Not Influence Insulin Sensitivity in Finnish Nondiabetic and NIDDM Subjects

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Topics: diabetes mellitus, type 2 , fatty acid-binding proteins , finnish , genes , insulin sensitivity

Diabetes April 1997, Vol.46, 711-712. doi:https://doi.org/10.2337/diab.46.4.711

Rapid Publications

Anti-Insulin Activity in Normal Newborn Cord-Blood Serum: Absence of IgG-Mediated Insulin Binding

J Ramón Bilbao; Begoña Calvo; Inés Urrutia; Alberto Linares; Luis Castaño

Abstracts

View articletitled, Anti-Insulin Activity in Normal Newborn Cord-Blood Serum: Absence of IgG-Mediated Insulin Binding

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Topics: immunoglobulin g , insulin , insulin binding , newborn , umbilical cord blood

Diabetes April 1997, Vol.46, 713-716. doi:https://doi.org/10.2337/diab.46.4.713

Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance

K E Zakrzewska; I Cusin; A Sainsbury; F Rohner-Jeanrenaud; B Jeanrenaud

Abstracts

View articletitled, Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance

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Topics: glucocorticoids , hormones , leptin

Diabetes April 1997, Vol.46, 717-719. doi:https://doi.org/10.2337/diab.46.4.717

Mutations in the Hepatocyte Nuclear Factor–1α Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K.

Timothy M Frayling; Michael P Bulman; Sian Ellard; Maggie Appleton; Mark J Dronsfield; Alasdair D R Mackie; Joyce D Baird; Pamela J Kaisaki; Kazuya Yamagata; Graeme I Bell; Stephen C Bain; Andrew T Hattersley

Abstracts

View articletitled, Mutations in the Hepatocyte Nuclear Factor–1α Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K.

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Topics: genes , hepatocytes , maturity onset diabetes mellitus in young , mutation

Diabetes April 1997, Vol.46, 720-725. doi:https://doi.org/10.2337/diab.46.4.720

Novel MODY3 Mutations in the Hepatocyte Nuclear Factor-1α Gene: Evidence for a Hyperexcitability of Pancreatic β-cells to Intravenous Secretagogues in a Glucose-Tolerant Carrier of a P447L Mutation

Torben Hansen; Hans Eiberg; Mathias Rouard; Martine Vaxillaire; Ann M Møller; Søren K Rasmussen; Marianne Fridberg; Søren A Urhammer; Jens J Holst; Katrine Almind; Søren M Echwald; Lars Hansen; Graeme I Bell; Oluf Pedersen

Abstracts

View articletitled, Novel MODY3 Mutations in the Hepatocyte Nuclear Factor-1α Gene: Evidence for a Hyperexcitability of Pancreatic β-cells to Intravenous Secretagogues in a Glucose-Tolerant Carrier of a P447L Mutation

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Topics: genes , glucose , hepatocytes , mutation , pancreas

Diabetes April 1997, Vol.46, 726-730. doi:https://doi.org/10.2337/diab.46.4.726

Erratum

View articletitled, Erratum

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Diabetes April 1997, Vol.46, 731. doi:https://doi.org/10.2337/diab.46.4.731

Organization Section

View articletitled, Organization Section

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Diabetes April 1997, Vol.46, 732. doi:https://doi.org/10.2337/diab.46.4.732

SI Units Table

Systém International (SI) Units Table

View articletitled, Systém International (SI) Units Table

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Diabetes April 1997, Vol.46, 733. doi:https://doi.org/10.2337/diab.46.4.733

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