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Volume 46, Issue 5
1 May 1997
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ISSN 0012-1797
EISSN 1939-327X
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Original Articles

Differential Activation of Mitogen-Activated Protein Kinase by Insulin and Epidermal Growth Factor in 3T3-L1 Adipocytes: A Possible Involvement of PI3-Kinase in the Activation of the MAP Kinase by Insulin
Junko Suga; Yasunao Yoshimasa; Kazunori Yamada; Yuji Yamamoto; Gen Inoue; Motozumi Okamoto; Tatsuya Hayashi; Michika Shigemoto; Atsushi Kosaki; Hideshi Kuzuya; Kazuwa Nakao
View articletitled, Differential Activation of Mitogen-Activated Protein Kinase by Insulin and Epidermal Growth Factor in 3T3-L1 Adipocytes: A Possible Involvement of PI3-Kinase in the Activation of the MAP Kinase by Insulin
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Diabetes May 1997, Vol.46, 735-741. doi:https://doi.org/10.2337/diab.46.5.735
Insulin Stimulates Nitric Oxide Synthesis in Human Platelets and, Through Nitric Oxide, Increases Platelet Concentrations of Both Guanosine-3′, 5′-Cyclic Monophosphate and Adenosine-3′, 5′-Cyclic Monophosphate
Mariella Trovati; Giovanni Anfossi; Paola Massucco; Luigi Mattiello; Costanzo Costamagna; Valentina Piretto; Elena Mularoni; Franco Cavalot; Amalia Bosia; Dario Ghigo
View articletitled, Insulin Stimulates Nitric Oxide Synthesis in Human Platelets and, Through Nitric Oxide, Increases Platelet Concentrations of Both Guanosine-3′, 5′-Cyclic Monophosphate and Adenosine-3′, 5′-Cyclic Monophosphate
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Diabetes May 1997, Vol.46, 742-749. doi:https://doi.org/10.2337/diab.46.5.742
Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse
Bronwyn A O'Brien; Brian V Harmon; Donald P Cameron; David J Allan
View articletitled, Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse
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Diabetes May 1997, Vol.46, 750-757. doi:https://doi.org/10.2337/diab.46.5.750
Hsp60 Peptide Therapy of NOD Mouse Diabetes Induces a Th2 Cytokine Burst and Downregulates Autoimmunity to Various β-Cell Antigens
Dana Elias; Aviram Meilin; Vitaly Ablamunits; Ohad S Birk; Pnina Carmi; Stephanie Könen-Waisman; Irun R Cohen
View articletitled, Hsp60 Peptide Therapy of NOD Mouse Diabetes Induces a Th2 Cytokine Burst and Downregulates Autoimmunity to Various β-Cell Antigens
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Diabetes May 1997, Vol.46, 758-765. doi:https://doi.org/10.2337/diab.46.5.758
Rejection of Islets Differing by a Single Antigen Is Dependent on Donor MHC
Murielle Vigneau-Hermellin; Letizia Vitali; Isabelle Tardivel; Myriam Rabaud; Michael V Holers; Jean-Claude Carel
View articletitled, Rejection of Islets Differing by a Single Antigen Is Dependent on Donor MHC
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Diabetes May 1997, Vol.46, 765-769. doi:https://doi.org/10.2337/diab.46.5.765
Interferon-γ Independently Activates the MHC Class I Antigen Processing Pathway and Diminishes Glucose Responsiveness in Pancreatic β-Cell Lines
Manuel E Baldeón; David J Neece; Dipankar Nandi; John J Monaco; H Rex Gaskins
View articletitled, Interferon-γ Independently Activates the MHC Class I Antigen Processing Pathway and Diminishes Glucose Responsiveness in Pancreatic β-Cell Lines
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Diabetes May 1997, Vol.46, 770-778. doi:https://doi.org/10.2337/diab.46.5.770
Effect of MHC Transgene Expression on Spontaneous Insulin Autoantibody Class Switch in Nonobese Diabetic Mice
Patricia Hutchings; Paul Tonks; Anne Cooke
View articletitled, Effect of MHC Transgene Expression on Spontaneous Insulin Autoantibody Class Switch in Nonobese Diabetic Mice
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Diabetes May 1997, Vol.46, 779-784. doi:https://doi.org/10.2337/diab.46.5.779
Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas
R Scott Heller; Timothy J Kieffer; Joel F Habener
View articletitled, Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas
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Diabetes May 1997, Vol.46, 785-791. doi:https://doi.org/10.2337/diab.46.5.785
Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca2+-Induced Secretion in Rat α-Cells by a Protein Kinase A–Mediated Mechanism
Wei-Guang Ding; Erik Renström; Patrik Rorsman; Karsten Buschard; Jesper Gromada
View articletitled, Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca<sup>2+</sup>-Induced Secretion in Rat α-Cells by a Protein Kinase A–Mediated Mechanism
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Diabetes May 1997, Vol.46, 792-800. doi:https://doi.org/10.2337/diab.46.5.792
Activation of Autonomic Nerves and the Adrenal Medulla Contributes to Increased Glucagon Secretion During Moderate Insulin-Induced Hypoglycemia in Women
Peter J Havel; Bo Ahren
View articletitled, Activation of Autonomic Nerves and the Adrenal Medulla Contributes to Increased Glucagon Secretion During Moderate Insulin-Induced Hypoglycemia in Women
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Diabetes May 1997, Vol.46, 801-807. doi:https://doi.org/10.2337/diab.46.5.801
Parallel Reduction of Pancreas Insulin Content and Insulin Secretion in 48-h Tolbutamide-Infused Normoglycemic Rats
Y A Hosokawa; Jack L Leahy
View articletitled, Parallel Reduction of Pancreas Insulin Content and Insulin Secretion in 48-h Tolbutamide-Infused Normoglycemic Rats
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Diabetes May 1997, Vol.46, 808-813. doi:https://doi.org/10.2337/diab.46.5.808
Contribution of Autonomic Neuropathy to Reduced Plasma Adrenaline Responses to Hypoglycemia in IDDM: Evidence for a Nonselective Defect
Paolo Bottini; Enrico Boschetti; Simone Pampanelli; Marco Ciofetta; Paola Del Sindaco; Luciano Scionti; Paolo Brunetti; Geremia B Bolli
View articletitled, Contribution of Autonomic Neuropathy to Reduced Plasma Adrenaline Responses to Hypoglycemia in IDDM: Evidence for a Nonselective Defect
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Diabetes May 1997, Vol.46, 814-823. doi:https://doi.org/10.2337/diab.46.5.814
Blood Glucose Lowering and Glucagonostatic Effects of Glucagon-Like Peptide I in Insulin-Deprived Diabetic Dogs
E-J Freyse; T Becher; El El-Hag; S Knospe; B Göke; U Fischer
View articletitled, Blood Glucose Lowering and Glucagonostatic Effects of Glucagon-Like Peptide I in Insulin-Deprived Diabetic Dogs
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Diabetes May 1997, Vol.46, 824-828. doi:https://doi.org/10.2337/diab.46.5.824
Importance of Cerebral Blood Flow to the Recognition of and Physiological Responses to Hypoglycemia
Thomas Matthew; Robert S Sherwin; June Murphy; David Kerr
View articletitled, Importance of Cerebral Blood Flow to the Recognition of and Physiological Responses to Hypoglycemia
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Diabetes May 1997, Vol.46, 829-833. doi:https://doi.org/10.2337/diab.46.5.829
Regulation of Glomerular Epithelial Cell Production of Fibronectin and Transforming Growth Factor-β by High Glucose, Not by Angiotensin II
Nicole F van Det; Nicole A M Verhagen; Jouke T Tamsma; Jo H M Berden; Jan A Bruijn; Mohamed R Daha; Fokko J van der Woude
View articletitled, Regulation of Glomerular Epithelial Cell Production of Fibronectin and Transforming Growth Factor-β by High Glucose, Not by Angiotensin II
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Diabetes May 1997, Vol.46, 834-840. doi:https://doi.org/10.2337/diab.46.5.834
Binding Properties of Glutamate Receptors in Streptozotocin-Induced Diabetes in Rats
Gagné Joël; Martin Milot; Sylvie Gélinas; Ahmed Lahsaïni; François Trudeau; Maria-Grazia Martinoli; Guy Massicotte
View articletitled, Binding Properties of Glutamate Receptors in Streptozotocin-Induced Diabetes in Rats
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Diabetes May 1997, Vol.46, 841-846. doi:https://doi.org/10.2337/diab.46.5.841
Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions
Masakazu Haneda; Shin-ichi Araki; Masaki Togawa; Toshiro Sugimoto; Isono Motohide; Ryuichi Kikkawa
View articletitled, Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions
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Diabetes May 1997, Vol.46, 847-853. doi:https://doi.org/10.2337/diab.46.5.847
Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes
Kumar Sharma; Fuad N Ziyadeh; Bashar Alzahabi; Tracy A McGowan; Shiv Kapoor; Brenda R C Kurnik; Peter B Kurnik; Lawernce S Weisberg
View articletitled, Increased Renal Production of Transforming Growth Factor-β<sub>1</sub> in Patients with Type II Diabetes
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Diabetes May 1997, Vol.46, 854-859. doi:https://doi.org/10.2337/diab.46.5.854
Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease
M C Alessi; F Peiretti; P Morange; M Henry; G Nalbone; I Juhan-Vague
View articletitled, Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease
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Diabetes May 1997, Vol.46, 860-867. doi:https://doi.org/10.2337/diab.46.5.860
Effect of Insulin on Systemic and Renal Handling of Albumin in Nondiabetic and NIDDM Subjects
Carlo Catalano; Elsa Muscelli; Alfredo Quiñones Galvan; Simona Baldi; Antonio Masoni; Ian Gibb; Ole Torffvit; Giuseppe Seghieri; Ele Ferrannini
View articletitled, Effect of Insulin on Systemic and Renal Handling of Albumin in Nondiabetic and NIDDM Subjects
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Diabetes May 1997, Vol.46, 868-875. doi:https://doi.org/10.2337/diab.46.5.868
New Susceptibility Locus for NIDDM Is Localized to Human Chromosome 20q
Linong Ji; Maciek Malecki; James H Warram; Yadong Yang; Stephen S Rich; Andrzej S Krolewski
View articletitled, New Susceptibility Locus for NIDDM Is Localized to Human Chromosome 20q
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Diabetes May 1997, Vol.46, 876-881. doi:https://doi.org/10.2337/diab.46.5.876
Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy
Donald W Bowden; Michèle Sale; Timothy D Howard; Asif Qadri; Beverly J Spray; Cynthia B Rothschild; Gita Akots; Stephen S Rich; Barry I Freedman
View articletitled, Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy
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Diabetes May 1997, Vol.46, 882-886. doi:https://doi.org/10.2337/diab.46.5.882
A Novel Locus, Mody4, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice
Masato Yoshioka; Tsuyoshi Kayo; Tsurumi Ikeda; Akio Koizuni
View articletitled, A Novel Locus, <em>Mody4</em>, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice
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Diabetes May 1997, Vol.46, 887-894. doi:https://doi.org/10.2337/diab.46.5.887

Rapid Publications

Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation
Sakurako Nakamura; Zenji Makita; Shintaro Ishikawa; Koichi Yasumura; Wataru Fujii; Katsuyuki Yanagisawa; Tetsuya Kawata; Takao Koike
View articletitled, Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation
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Diabetes May 1997, Vol.46, 895-899. doi:https://doi.org/10.2337/diab.46.5.895
Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis
Ruth E Gimeno; Marlene Dembski; Xun Weng; Nanhua Deng; Andrew W Shyjan; Carlos J Gimeno; Francois Iris; Stephen J Ellis; Elizabeth A Woolf; Louis A Tartaglia
View articletitled, Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis
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Diabetes May 1997, Vol.46, 900-906. doi:https://doi.org/10.2337/diab.46.5.900
Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells
Wilma L Suarez-Pinzon; Casaba Szabó; Alex Rabinovitch
View articletitled, Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells
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Diabetes May 1997, Vol.46, 907-911. doi:https://doi.org/10.2337/diab.46.5.907
A Prevalent Amino Acid Polymorphism at Codon 98 in the Hepatocyte Nuclear Factor-1α Gene Is Associated With Reduced Serum C-Peptide and Insulin Responses to an Oral Glucose Challenge
Søen A Urhammer; Marianne Fridberg; Torben Hansen; Søren K Rasmussen; Ann Merete Møller; Jesper O Clausen; Oluf Pedersen
View articletitled, A Prevalent Amino Acid Polymorphism at Codon 98 in the Hepatocyte Nuclear Factor-1α Gene Is Associated With Reduced Serum C-Peptide and Insulin Responses to an Oral Glucose Challenge
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Diabetes May 1997, Vol.46, 912-916. doi:https://doi.org/10.2337/diab.46.5.912
Leptin Is Present in Human Cord Blood
Eyal Sivan; W Michael Lin; Carol J Homko; E Albert Reece; Guenther Boden
View articletitled, Leptin Is Present in Human Cord Blood
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Diabetes May 1997, Vol.46, 917-919. doi:https://doi.org/10.2337/diab.46.5.917
Increased Prevalence of Mitochondrial DNA Deletions in Skeletal Muscle of Older Individuals With Impaired Glucose Tolerance: Possible Marker of Glycemic Stress
Ping Liang; Virginia Hughes; Naomi K Fukagawa
View articletitled, Increased Prevalence of Mitochondrial DNA Deletions in Skeletal Muscle of Older Individuals With Impaired Glucose Tolerance: Possible Marker of Glycemic Stress
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Diabetes May 1997, Vol.46, 920-924. doi:https://doi.org/10.2337/diab.46.5.920

Errata

Errata
View articletitled, Errata
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Diabetes May 1997, Vol.46, 924. doi:https://doi.org/10.2337/diab.46.5.924

SI Units Table

Système International (SI) Units Table
View articletitled, Système International (SI) Units Table
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Diabetes May 1997, Vol.46, 925. doi:https://doi.org/10.2337/diab.46.5.925

Organization Section

Organization Section
View articletitled, Organization Section
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Diabetes May 1997, Vol.46, 926. doi:https://doi.org/10.2337/diab.46.5.926
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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