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Volume 47, Issue 2
1 February 1998
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ISSN 0012-1797
EISSN 1939-327X
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1997 Presidential Address

We Are What We Repeatedly Do
Philip E Cryer
View articletitled, We Are What We Repeatedly Do
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Diabetes February 1998, Vol.47, 155-158. doi:https://doi.org/10.2337/diab.47.2.155

Perspectives in Diabetes

Glucagon-Like Peptides
Daniel J Drucker
View articletitled, Glucagon-Like Peptides
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Diabetes February 1998, Vol.47, 159-169. doi:https://doi.org/10.2337/diab.47.2.159

Original Articles

Metabolism and Signal Transdution
Expression of Glutamine:Fructose-6-Phosphate Amidotransferase in Human Tissues: Evidence for High Variability and Distinct Regulation in Diabetes
Andreas G Nerlich; Ulrich Sauer; Verena Kolm-Litty; Eva Wagner; Matthias Koch; Erwin D Schleicher
View articletitled, Expression of Glutamine:Fructose-6-Phosphate Amidotransferase in Human Tissues: Evidence for High Variability and Distinct Regulation in Diabetes
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Diabetes February 1998, Vol.47, 170-178. doi:https://doi.org/10.2337/diab.47.2.170
Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3-Kinase–Mediating Glucose Transport and Lipogenesis
Ralph W Stevenson; David K Kreutter; Kim M Andrews; Paul E Genereux; E Michael Gibbs
View articletitled, Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3-Kinase–Mediating Glucose Transport and Lipogenesis
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Diabetes February 1998, Vol.47, 179-185. doi:https://doi.org/10.2337/diab.47.2.179
Immunology and Transplantation
The B-Subunit of Cholera Toxin Induces Immunoregulatory Cells and Prevents Diabetes in the NOD Mouse
Douglas O Sobel; Boris Yankelevich; Deepshikha Goyal; David Nelson; Amitabha Mazumder
View articletitled, The B-Subunit of Cholera Toxin Induces Immunoregulatory Cells and Prevents Diabetes in the NOD Mouse
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Diabetes February 1998, Vol.47, 186-191. doi:https://doi.org/10.2337/diab.47.2.186
Normoglycemia Restores β-Cell Replicative Response to Glucose in Transplanted Islets Exposed to Chronic Hyperglycemia
Victor Nacher; Juan F Merino; Mercè Raurell; Joan Soler; Eduard Montanya
View articletitled, Normoglycemia Restores β-Cell Replicative Response to Glucose in Transplanted Islets Exposed to Chronic Hyperglycemia
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Diabetes February 1998, Vol.47, 192-196. doi:https://doi.org/10.2337/diab.47.2.192
Excessive Production of Nitric Oxide by Macrophages From DP-BB Rats Is Secondary to the T-Lymphopenic State of These Animals
Albert Lau; Sheela Ramanathan; Philippe Poussier
View articletitled, Excessive Production of Nitric Oxide by Macrophages From DP-BB Rats Is Secondary to the T-Lymphopenic State of These Animals
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Diabetes February 1998, Vol.47, 197-205. doi:https://doi.org/10.2337/diab.47.2.197
Islet Studies
4-Hydroxyisoleucine: A Novel Amino Acid Potentiator of Insulin Secretion
Yves Sauvaire; Pierre Petit; Christophe Broca; Michèle Manteghetti; Yves Baissac; Josepha Fernandez-Alvarez; Renè Gross; Michèle Roye; Agnès Leconte; Ramon Gomis; Gèrard Ribes
View articletitled, 4-Hydroxyisoleucine: A Novel Amino Acid Potentiator of Insulin Secretion
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Diabetes February 1998, Vol.47, 206-210. doi:https://doi.org/10.2337/diab.47.2.206
RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells
Ioulia B Efanova; Sergei V Zaitsev; Graham Brown; Per-Olof Berggren; Suad Efendić
View articletitled, RX871024 Induces Ca<sup>2+</sup> Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells
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Diabetes February 1998, Vol.47, 211-218. doi:https://doi.org/10.2337/diab.47.2.211
Effects of Leptin on Insulin Secretion From Isolated Rat Pancreatic Islets
Mari Ookuma; Kazuyoshi Ookuma; David A York
View articletitled, Effects of Leptin on Insulin Secretion From Isolated Rat Pancreatic Islets
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Diabetes February 1998, Vol.47, 219-223. doi:https://doi.org/10.2337/diab.47.2.219
Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide
Pellegrino Masiello; Christophe Broca; René Gross; Michèle Roye; Michèle Manteghetti; Dominique Hillaire-Buys; Michela Novelli; Gérard Ribes
View articletitled, Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide
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Diabetes February 1998, Vol.47, 224-229. doi:https://doi.org/10.2337/diab.47.2.224
Pathophysiology
Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations
Christos S Mantzoros; Robert C Frederich; Daqing Qu; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
View articletitled, Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations
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Diabetes February 1998, Vol.47, 230-238. doi:https://doi.org/10.2337/diab.47.2.230
Increased Plasma Leptin Levels Are Associated With Fat Accumulation in Japanese Americans
Steven D Chessler; Wilfred Y Fujimoto; Jane B Shofer; Edward J Boyko; David S Weigle
View articletitled, Increased Plasma Leptin Levels Are Associated With Fat Accumulation in Japanese Americans
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Diabetes February 1998, Vol.47, 239-243. doi:https://doi.org/10.2337/diab.47.2.239
Plasma Leptin Concentrations Do Not Appear to Decrease Insulin-Mediated Glucose Disposal or Glucose-Stimulated Insulin Secretion in Women With Normal Glucose Tolerance
Marcello Carantoni; Fahim Abbasi; Salman Azhar; Yii-Der I Chen; Mark Klebanov; Pei-Wen Wang; Fabienne Warmerdam; Gerald M Reaven
View articletitled, Plasma Leptin Concentrations Do Not Appear to Decrease Insulin-Mediated Glucose Disposal or Glucose-Stimulated Insulin Secretion in Women With Normal Glucose Tolerance
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Diabetes February 1998, Vol.47, 244-247. doi:https://doi.org/10.2337/diab.47.2.244
β-Hydroxybutyrate Increases Reactive Oxygen Species in Late but Not in Early Postimplantation Embryonic Cells In Vitro
Henrik Forsberg; Ulf J Eriksson; Öjar Melefors; Nils Welsh
View articletitled, β-Hydroxybutyrate Increases Reactive Oxygen Species in Late but Not in Early Postimplantation Embryonic Cells In Vitro
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Diabetes February 1998, Vol.47, 255-262. doi:https://doi.org/10.2337/diab.47.2.255
Complications
Coronary Flow Reserve Is Reduced in Young Men With IDDM
Olli-Pekka Pitkänen; Pirjo Nuutila; Olli T Raitakari; Tapani Rönnemaa; Pertti J Koskinen; Hidehiro Iida; Terho J Lehtimäki; Hanna K Laine; Teemu Takala; Jorma S A Viikari; Juhani Knuuti
View articletitled, Coronary Flow Reserve Is Reduced in Young Men With IDDM
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Diabetes February 1998, Vol.47, 248-254. doi:https://doi.org/10.2337/diab.47.2.248
Genetics
Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection
P Hanifi Moghaddam; P de Knijf; B O Roep; B Van der Auwera; A Naipal; F Gorus; F Schuit; M J Giphart; Belgian Diabetes Registry
View articletitled, Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection
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Diabetes February 1998, Vol.47, 263-269. doi:https://doi.org/10.2337/diab.47.2.263
Epidemiology
Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men
Jukka T Salonen; Timo A Lakka; Hanna-Maaria Lakka; Veli-Pekka Valkonen; Susan A Everson; George A Kaplan
View articletitled, Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men
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Diabetes February 1998, Vol.47, 270-275. doi:https://doi.org/10.2337/diab.47.2.270

Brief Genetics Reports

New Mitochondrial DNA Homoplasmic Mutations Associated With Japanese Patients With Type 2 Diabetes
Masato Tawata; Masayuki Ohtaka; Eiichi Iwase; Yukinobu Ikegishi; Kaoru Aida; Toshimasa Onaya
View articletitled, New Mitochondrial DNA Homoplasmic Mutations Associated With Japanese Patients With Type 2 Diabetes
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Diabetes February 1998, Vol.47, 276-277. doi:https://doi.org/10.2337/diab.47.2.276
Association of Apolipoprotein ε2 Allele With Diabetic Nephropathy in Caucasian Subjects With IDDM
Tahseen A Chowdhury; Philip H Dyer; Sudesh Kumar; Simon P Gibson; Bethan R Rowe; Simon J Davies; Sally M Marshall; Peter J Morris; Geoffrey V Gill; Susan Feeney; Peter Maxwell; David Savage; Andrew J M Boulton; John A Todd; David Dunger; Anthony H Barnett; Stephen C Bain
View articletitled, Association of Apolipoprotein ε2 Allele With Diabetic Nephropathy in Caucasian Subjects With IDDM
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Diabetes February 1998, Vol.47, 278-280. doi:https://doi.org/10.2337/diab.47.2.278
Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients
Ole Peter Kristiansen; Mahdi Zamani; Jesper Johannesen; Thomas Mandrup-Poulsen; Jean-Jacques Cassiman; Jørn Nerup; Flemming Pociot; The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood
View articletitled, Linkage and Association Between a <em>CD4</em> Gene Polymorphism and IDDM in Danish IDDM Patients
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Diabetes February 1998, Vol.47, 281-283. doi:https://doi.org/10.2337/diab.47.2.281
Human Hormone-Sensitive Lipase: Genetic Mapping, Identification of a New Dinucleotide Repeat, and Association With Obesity and NIDDM
Jocelyne Magré; Henrik Laurell; Cécile Fizames; Pierre J Antoine; Colette Dib; Corinne Vigouroux; Charlotte Bourut; Jacqueline Capeau; Jean Weissenbach; Dominique Langin
View articletitled, Human Hormone-Sensitive Lipase: Genetic Mapping, Identification of a New Dinucleotide Repeat, and Association With Obesity and NIDDM
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Diabetes February 1998, Vol.47, 284-286. doi:https://doi.org/10.2337/diab.47.2.284
Prohormone Convertase 1 in Obesity, Gestational Diabetes Mellitus, and NIDDM: No Evidence for a Major Susceptibility Role
Kamini Kalidas; Eleanor Dow; Philip J Saker; Nicholas Wareham; David Halsall; Robert S Jackson; Siew-Pheng Chan; Susan Gelding; Mark Walker; Eleni Kousta; Desmond G Johnston; Stephen O'Rahilly; Mark I McCarthy
View articletitled, Prohormone Convertase 1 in Obesity, Gestational Diabetes Mellitus, and NIDDM: No Evidence for a Major Susceptibility Role
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Diabetes February 1998, Vol.47, 287-289. doi:https://doi.org/10.2337/diab.47.2.287

Rapid Publications

Induction of Hyperinsulinemia Combined With Hyperglycemia and Hypertriglyceridemia Increases Plasminogen Activator Inhibitor 1 in Blood in Normal Human Subjects
Jorge Calles-Escandon; Shirwan A Mirza; Burton E Sobel; David J Schneider
View articletitled, Induction of Hyperinsulinemia Combined With Hyperglycemia and Hypertriglyceridemia Increases Plasminogen Activator Inhibitor 1 in Blood in Normal Human Subjects
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Diabetes February 1998, Vol.47, 290-293. doi:https://doi.org/10.2337/diab.47.2.290
Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin
Tooru M Mizuno; Steven P Kleopoulos; Hugo T Bergen; James L Roberts; Catherine A Priest; Charles V Mobbs
View articletitled, Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in <em>ob/ob</em> and <em>db/db</em> Mice, but Is Stimulated by Leptin
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Diabetes February 1998, Vol.47, 294-297. doi:https://doi.org/10.2337/diab.47.2.294
Elevated Free Fatty Acids Induce Uncoupling Protein 3 Expression in Muscle: A Potential Explanation for the Effect of Fasting
David S Weigle; Leah E Selfridge; Michael W Schwartz; Randy J Seeley; David E Cummings; Peter J Havel; Joseph L Kuijper; Hector BeltrandelRio
View articletitled, Elevated Free Fatty Acids Induce Uncoupling Protein 3 Expression in Muscle: A Potential Explanation for the Effect of Fasting
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Diabetes February 1998, Vol.47, 298-302. doi:https://doi.org/10.2337/diab.47.2.298

Erratum

Erratum
View articletitled, Erratum
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Diabetes February 1998, Vol.47, 303. doi:https://doi.org/10.2337/diab.47.2.303

Organization Section

Organization Section
View articletitled, Organization Section
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Diabetes February 1998, Vol.47, 304-305. doi:https://doi.org/10.2337/diab.47.2.304

(SI) Units Table

Système International (SI) units for plasma, serum, or blood concentrations
View articletitled, Système International (SI) units for plasma, serum, or blood concentrations
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Diabetes February 1998, Vol.47, 306. doi:https://doi.org/10.2337/diab.47.2.306
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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