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Volume 47, Issue 7

1 July 1998

ISSN 0012-1797

EISSN 1939-327X

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Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

G J Taborsky, Jr; B Ahrén; P J Havel

Abstract

View articletitled, Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

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Topics: autonomic nervous system , diabetes mellitus, type 1 , glucagon secretion , hypoglycemia , pancreatic alpha cell

Diabetes July 1998, Vol.47, 995-1005. doi:https://doi.org/10.2337/diabetes.47.7.995

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

E Hajduch; D R Alessi; B A Hemmings; H S Hundal

Abstract

View articletitled, Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

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Topics: amino acids , carrier proteins , glucose , glycogen synthase kinase 3 , muscle cells

Diabetes July 1998, Vol.47, 1006-1013. doi:https://doi.org/10.2337/diabetes.47.7.1006

Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.

I Cusin; K E Zakrzewska; O Boss; P Muzzin; J P Giacobino; D Ricquier; B Jeanrenaud; F Rohner-Jeanrenaud

Abstract

View articletitled, Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.

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Topics: glucose metabolism , infusion procedures , insulin , leptin , mitochondrial uncoupling proteins

Diabetes July 1998, Vol.47, 1014-1019. doi:https://doi.org/10.2337/diabetes.47.7.1014

Glucose turnover and insulin sensitivity in rats with pancreatic islet transplants.

J Guan; M T Behme; P Zucker; P Atkison; I Hramiak; R Zhong; J Dupré

Abstract

View articletitled, Glucose turnover and insulin sensitivity in rats with pancreatic islet transplants.

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Topics: endocrine pancreas , glucose , insulin sensitivity , rats

Diabetes July 1998, Vol.47, 1020-1026. doi:https://doi.org/10.2337/diabetes.47.7.1020

Measurements of oxygen tension in native and transplanted rat pancreatic islets.

P O Carlsson; P Liss; A Andersson; L Jansson

Abstract

View articletitled, Measurements of oxygen tension in native and transplanted rat pancreatic islets.

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Topics: arterial oxygen tension , endocrine pancreas

Diabetes July 1998, Vol.47, 1027-1032. doi:https://doi.org/10.2337/diabetes.47.7.1027

Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice: treatment with 1,25(OH)2D3 restores defect.

K M Casteels; C A Gysemans; M Waer; R Bouillon; J M Laureys; J Depovere; C Mathieu

Abstract

View articletitled, Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice: treatment with 1,25(OH)2D3 restores defect.

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Topics: apoptosis , dexamethasone , mice, inbred nod , sex characteristics

Diabetes July 1998, Vol.47, 1033-1037. doi:https://doi.org/10.2337/diabetes.47.7.1033

Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene.

M Cordier-Bussat; C Bernard; F Levenez; N Klages; B Laser-Ritz; J Philippe; J A Chayvialle; J C Cuber

Abstract

View articletitled, Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene.

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Topics: bodily secretions , genes , glucagon-like peptide 1 , hormones , incretin

Diabetes July 1998, Vol.47, 1038-1045. doi:https://doi.org/10.2337/diabetes.47.7.1038

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

R A Pederson; M Satkunarajah; C H McIntosh; L A Scrocchi; D Flamez; F Schuit; D J Drucker; M B Wheeler

Abstract

View articletitled, Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

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Topics: bodily secretions , glucagon-like peptide 1 , glucose , mice

Diabetes July 1998, Vol.47, 1046-1052. doi:https://doi.org/10.2337/diabetes.47.7.1046

Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

S G Straub; R F James; M J Dunne; G W Sharp

Abstract

View articletitled, Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

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Topics: endocrine pancreas , glucose , insulin secretion

Diabetes July 1998, Vol.47, 1053-1057. doi:https://doi.org/10.2337/diabetes.47.7.1053

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

C Bernard; C Thibault; M F Berthault; C Magnan; C Saulnier; B Portha; W F Pralong; L Pénicaud; A Ktorza

Abstract

View articletitled, Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

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Topics: glucose , infusion procedures , pancreas , pancreatic beta cell , rats

Diabetes July 1998, Vol.47, 1058-1065. doi:https://doi.org/10.2337/diabetes.47.7.1058

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

C A Leech; J F Habener

Abstract

View articletitled, A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

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Topics: calcium ions , cations , membrane potentials , pancreas

Diabetes July 1998, Vol.47, 1066-1073. doi:https://doi.org/10.2337/diabetes.47.7.1066

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

G T Schuppin; S Pons; S Hügl; L P Aiello; G L King; M White; C J Rhodes

Abstract

View articletitled, A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

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Topics: irs2 protein, human , pancreas , pancreatic beta cell , insulinoma , rna, messenger

Diabetes July 1998, Vol.47, 1074-1085. doi:https://doi.org/10.2337/diabetes.47.7.1074

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

E Roche; S Farfari; L A Witters; F Assimacopoulos-Jeannet; S Thumelin; T Brun; B E Corkey; A K Saha; M Prentki

Abstract

View articletitled, Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

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Topics: gene expression , glucose , lipogenesis

Diabetes July 1998, Vol.47, 1086-1094. doi:https://doi.org/10.2337/diabetes.47.7.1086

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

L Frittitta; D Spampinato; A Solini; R Nosadini; I D Goldfine; R Vigneri; V Trischitta

Abstract

View articletitled, Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

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Topics: cultured skin , fibroblasts , insulin , insulin receptor , intrinsic factor

Diabetes July 1998, Vol.47, 1095-1100. doi:https://doi.org/10.2337/diabetes.47.7.1095

Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia.

E Cersosimo; P E Molina; N N Abumrad

Abstract

View articletitled, Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia.

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Topics: gluconeogenesis , hypoglycemia , insulin , kidney , lactates

Diabetes July 1998, Vol.47, 1101-1106. doi:https://doi.org/10.2337/diabetes.47.7.1101

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.

Y T Kruszynska; M I Mulford; J Baloga; J G Yu; J M Olefsky

Abstract

View articletitled, Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.

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Topics: diabetes mellitus, type 2 , hexokinase , insulin , skeletal muscles

Diabetes July 1998, Vol.47, 1107-1113. doi:https://doi.org/10.2337/diabetes.47.7.1107

Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.

I Giardino; A K Fard; D L Hatchell; M Brownlee

Abstract

View articletitled, Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.

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Topics: apoptosis , lipid peroxidation , oxidants , pimagedine , reactive oxygen species

Diabetes July 1998, Vol.47, 1114-1120. doi:https://doi.org/10.2337/diabetes.47.7.1114

Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients.

S Rudberg; E L Stattin; G Dahlquist

Abstract

View articletitled, Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients.

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Topics: diabetes mellitus, type 1 , microbiology procedures , perinatal period

Diabetes July 1998, Vol.47, 1121-1126. doi:https://doi.org/10.2337/diabetes.47.7.1121

Contribution of the endothelium to transcapillary insulin transport in rat isolated perfused hearts.

F Brunner; T C Wascher

Abstract

View articletitled, Contribution of the endothelium to transcapillary insulin transport in rat isolated perfused hearts.

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Topics: endothelium , heart , insulin

Diabetes July 1998, Vol.47, 1127-1134. doi:https://doi.org/10.2337/diabetes.47.7.1127

Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats.

T Nagaoka; T Shirakawa; T W Balon; J C Russell; Y Fujita-Yamaguchi

Abstract

View articletitled, Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats.

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Topics: adipose tissue , aorta , atherosclerosis , insulin , nucleotides, cyclic

Diabetes July 1998, Vol.47, 1135-1144. doi:https://doi.org/10.2337/diabetes.47.7.1135

Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

S L Shyng; T Ferrigni; J B Shepard; A Nestorowicz; B Glaser; M A Permutt; C G Nichols

Abstract

View articletitled, Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

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Topics: mutation , nesidioblastosis , sulfonylurea receptor

Diabetes July 1998, Vol.47, 1145-1151. doi:https://doi.org/10.2337/diabetes.47.7.1145

Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.

F Beards; T Frayling; M Bulman; Y Horikawa; L Allen; M Appleton; G I Bell; S Ellard; A T Hattersley

View articletitled, Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.

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Topics: hepatocytes , maturity onset diabetes mellitus in young , mutation

Diabetes July 1998, Vol.47, 1152-1154. doi:https://doi.org/10.2337/diabetes.47.7.1152

Identification of polymorphisms in the receptor for advanced glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups.

B I Hudson; M H Stickland; P J Grant

View articletitled, Identification of polymorphisms in the receptor for advanced glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups.

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Topics: diabetes mellitus, type 2 , genes , polymorphism , rage , receptor for advanced glycation endproducts

Diabetes July 1998, Vol.47, 1155-1157. doi:https://doi.org/10.2337/diabetes.47.7.1155

CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families.

H Donner; C Seidl; J Braun; T Siegmund; J Herwig; E Seifried; K H Usadel; K Badenhoop

View articletitled, CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families.

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Topics: alleles , diabetes mellitus, type 1 , genes , haplotypes , human leukocyte antigens

Diabetes July 1998, Vol.47, 1158-1160. doi:https://doi.org/10.2337/diabetes.47.7.1158

Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting.

B G Fogelson; S I Nawas; W T Vigneswaran; J L Ferguson; W R Law; A C Sharma

Abstract

View articletitled, Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting.

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Topics: coronary artery bypass surgery , coronary sinus , endothelin-1

Diabetes July 1998, Vol.47, 1161-1163. doi:https://doi.org/10.2337/diabetes.47.7.1161

Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis.

D K Moczulski; J J Rogus; A Antonellis; J H Warram; A S Krolewski

Abstract

View articletitled, Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis.

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Topics: chromosomes , diabetes mellitus, type 1 , kidney diseases

Diabetes July 1998, Vol.47, 1164-1169. doi:https://doi.org/10.2337/diabetes.47.7.1164

Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.

Glucose turnover and insulin sensitivity in rats with pancreatic islet transplants.

Measurements of oxygen tension in native and transplanted rat pancreatic islets.

Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice: treatment with 1,25(OH)2D3 restores defect.

Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene.

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia.

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.

Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.

Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients.

Contribution of the endothelium to transcapillary insulin transport in rat isolated perfused hearts.

Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats.

Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.

Identification of polymorphisms in the receptor for advanced glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups.

CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families.

Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting.

Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis.

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