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Targeting autoimmune diabetes with gene therapy.
Topics:
autoimmunity
,
gene therapy
,
insulin
,
diabetes mellitus, type 1
,
heart diseases
Diabetes November 1999, Vol.48, 2107-2121. doi:https://doi.org/10.2337/diabetes.48.11.2107
Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.
Topics:
adipocytes
,
insulin
,
insulin receptor substrate proteins
,
irs1 protein, human
,
lipogenesis
Diabetes November 1999, Vol.48, 2122-2131. doi:https://doi.org/10.2337/diabetes.48.11.2122
Hypothalamic orexin expression: modulation by blood glucose and feeding.
X J Cai; P S Widdowson; J Harrold; S Wilson; R E Buckingham; J R Arch; M Tadayyon; J C Clapham; J Wilding; G Williams
Topics:
blood glucose
,
hypothalamus
,
orexins
Diabetes November 1999, Vol.48, 2132-2137. doi:https://doi.org/10.2337/diabetes.48.11.2132
Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity.
J J Couper; C Steele; S Beresford; T Powell; K McCaul; A Pollard; S Gellert; B Tait; L C Harrison; P G Colman
Topics:
autoimmunity
,
cow's milk
,
antibodies
,
diabetes mellitus, type 1
,
autoantibodies
Diabetes November 1999, Vol.48, 2145-2149. doi:https://doi.org/10.2337/diabetes.48.11.2145
Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.
Topics:
administration, oral
,
autoimmunity
,
cholera toxin
,
insulin
,
mice, inbred nod
Diabetes November 1999, Vol.48, 2150-2156. doi:https://doi.org/10.2337/diabetes.48.11.2150
Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes.
Topics:
cross reactions
,
diabetes mellitus, type 1
,
epitopes
,
insulin
,
mice
Diabetes November 1999, Vol.48, 2157-2165. doi:https://doi.org/10.2337/diabetes.48.11.2157
Heterophile anti-mouse immunoglobulin antibodies may interfere with cytokine measurements in patients with HLA alleles protective for type 1A diabetes.
M J Redondo; P A Gottlieb; T Motheral; C Mulgrew; M Rewers; S Babu; E Stephens; D R Wegmann; G S Eisenbarth
Topics:
alleles
,
antibodies
,
cytokine
,
human leukocyte antigens
,
immunoglobulins
Diabetes November 1999, Vol.48, 2166-2170. doi:https://doi.org/10.2337/diabetes.48.11.2166
Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells.
Topics:
insulin secretion
,
mice
,
pancreas
,
calcium ions
Diabetes November 1999, Vol.48, 2171-2181. doi:https://doi.org/10.2337/diabetes.48.11.2171
Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.
Topics:
diabetes mellitus, type 2
,
glucose uptake
,
insulin secretion
Diabetes November 1999, Vol.48, 2182-2188. doi:https://doi.org/10.2337/diabetes.48.11.2182
Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.
Topics:
dominant inheritance
,
stress
Diabetes November 1999, Vol.48, 2189-2196. doi:https://doi.org/10.2337/diabetes.48.11.2189
Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.
Topics:
glucose intolerance
,
impaired fasting glucose
Diabetes November 1999, Vol.48, 2197-2203. doi:https://doi.org/10.2337/diabetes.48.11.2197
Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor.
Topics:
eating
,
leptin
,
mice
,
mice, inbred c57bl
,
peptides
Diabetes November 1999, Vol.48, 2204-2209. doi:https://doi.org/10.2337/diabetes.48.11.2204
Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women.
Topics:
insulin resistance
,
obesity
,
phenotype
Diabetes November 1999, Vol.48, 2210-2214. doi:https://doi.org/10.2337/diabetes.48.11.2210
Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.
Topics:
cytosol
,
heterogeneity
,
kidney
,
liver
,
proteolysis
Diabetes November 1999, Vol.48, 2215-2220. doi:https://doi.org/10.2337/diabetes.48.11.2215
Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.
Diabetes November 1999, Vol.48, 2221-2228. doi:https://doi.org/10.2337/diabetes.48.11.2221
Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.
M E Cooper; D Vranes; S Youssef; S A Stacker; A J Cox; B Rizkalla; D J Casley; L A Bach; D J Kelly; R E Gilbert
Topics:
diabetes mellitus, experimental
,
kidney
,
vascular endothelial growth factor a
,
vascular endothelial growth factor receptor-2
Diabetes November 1999, Vol.48, 2229-2239. doi:https://doi.org/10.2337/diabetes.48.11.2229
Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studies.
Topics:
adverse effects
,
hyperglycemia
,
kidney development
,
rats
Diabetes November 1999, Vol.48, 2240-2245. doi:https://doi.org/10.2337/diabetes.48.11.2240
Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.
Topics:
chromosome 12q
,
diabetes mellitus, type 2
Diabetes November 1999, Vol.48, 2246-2251. doi:https://doi.org/10.2337/diabetes.48.11.2246
