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Volume 48, Issue 11

1 November 1999

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Table of Contents

ISSN 0012-1797

EISSN 1939-327X

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Targeting autoimmune diabetes with gene therapy.

N Giannoukakis; W A Rudert; P D Robbins; M Trucco

Abstract

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Diabetes November 1999, Vol.48, 2107-2121. doi:https://doi.org/10.2337/diabetes.48.11.2107

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

A M Valverde; C R Kahn; M Benito

Abstract

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Diabetes November 1999, Vol.48, 2122-2131. doi:https://doi.org/10.2337/diabetes.48.11.2122

Hypothalamic orexin expression: modulation by blood glucose and feeding.

X J Cai; P S Widdowson; J Harrold; S Wilson; R E Buckingham; J R Arch; M Tadayyon; J C Clapham; J Wilding; G Williams

Abstract

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Diabetes November 1999, Vol.48, 2132-2137. doi:https://doi.org/10.2337/diabetes.48.11.2132

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

A M Martin; M N Maxson; J Leif; J P Mordes; D L Greiner; E P Blankenhorn

Abstract

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Diabetes November 1999, Vol.48, 2138-2144. doi:https://doi.org/10.2337/diabetes.48.11.2138

Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity.

J J Couper; C Steele; S Beresford; T Powell; K McCaul; A Pollard; S Gellert; B Tait; L C Harrison; P G Colman

Abstract

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Diabetes November 1999, Vol.48, 2145-2149. doi:https://doi.org/10.2337/diabetes.48.11.2145

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

C Ploix; I Bergerot; A Durand; C Czerkinsky; J Holmgren; C Thivolet

Abstract

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Diabetes November 1999, Vol.48, 2150-2156. doi:https://doi.org/10.2337/diabetes.48.11.2150

Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes.

V L Heath; P Hutchings; D J Fowell; A Cooke; D W Mason

Abstract

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Diabetes November 1999, Vol.48, 2157-2165. doi:https://doi.org/10.2337/diabetes.48.11.2157

Heterophile anti-mouse immunoglobulin antibodies may interfere with cytokine measurements in patients with HLA alleles protective for type 1A diabetes.

M J Redondo; P A Gottlieb; T Motheral; C Mulgrew; M Rewers; S Babu; E Stephens; D R Wegmann; G S Eisenbarth

Abstract

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Diabetes November 1999, Vol.48, 2166-2170. doi:https://doi.org/10.2337/diabetes.48.11.2166

Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells.

C R Poulsen; K Bokvist; H L Olsen; M Høy; K Capito; P Gilon; J Gromada

Abstract

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Diabetes November 1999, Vol.48, 2171-2181. doi:https://doi.org/10.2337/diabetes.48.11.2171

Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.

G Boden; X Chen; M Polansky

Abstract

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Diabetes November 1999, Vol.48, 2182-2188. doi:https://doi.org/10.2337/diabetes.48.11.2182

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.

C E Mathews; E H Leiter

Abstract

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Diabetes November 1999, Vol.48, 2189-2196. doi:https://doi.org/10.2337/diabetes.48.11.2189

Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.

C Weyer; C Bogardus; R E Pratley

Abstract

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Diabetes November 1999, Vol.48, 2197-2203. doi:https://doi.org/10.2337/diabetes.48.11.2197

Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor.

P Grasso; D W White; L A Tartaglia; M C Leinung; D W Lee

Abstract

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Diabetes November 1999, Vol.48, 2204-2209. doi:https://doi.org/10.2337/diabetes.48.11.2204

Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women.

R V Dvorak; W F DeNino; P A Ades; E T Poehlman

Abstract

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Diabetes November 1999, Vol.48, 2210-2214. doi:https://doi.org/10.2337/diabetes.48.11.2210

Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

M Portero-Otín; R Pamplona; M C Ruiz; E Cabiscol; J Prat; M J Bellmunt

Abstract

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Diabetes November 1999, Vol.48, 2215-2220. doi:https://doi.org/10.2337/diabetes.48.11.2215

Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.

R A Rabini; N Cester; R Staffolani; E Salvolini; N Moretti; A Vignini; D Fumelli; L Mazzanti

Abstract

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Diabetes November 1999, Vol.48, 2221-2228. doi:https://doi.org/10.2337/diabetes.48.11.2221

Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.

M E Cooper; D Vranes; S Youssef; S A Stacker; A J Cox; B Rizkalla; D J Casley; L A Bach; D J Kelly; R E Gilbert

Abstract

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Diabetes November 1999, Vol.48, 2229-2239. doi:https://doi.org/10.2337/diabetes.48.11.2229

Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studies.

K Amri; N Freund; J Vilar; C Merlet-Bénichou; M Lelièvre-Pégorier

Abstract

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Diabetes November 1999, Vol.48, 2240-2245. doi:https://doi.org/10.2337/diabetes.48.11.2240

Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.

A Bektas; M E Suprenant; L T Wogan; N Plengvidhya; S S Rich; J H Warram; A S Krolewski; A Doria

Abstract

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Diabetes November 1999, Vol.48, 2246-2251. doi:https://doi.org/10.2337/diabetes.48.11.2246

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34-OR: The Effect of Combined Activin A and Myostatin Blockade on Body Composition—A Phase 1 Trial

Targeting autoimmune diabetes with gene therapy.

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Hypothalamic orexin expression: modulation by blood glucose and feeding.

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity.

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes.

Heterophile anti-mouse immunoglobulin antibodies may interfere with cytokine measurements in patients with HLA alleles protective for type 1A diabetes.

Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells.

Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.

Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.

Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor.

Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women.

Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.

Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.

Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studies.

Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.

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