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How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
Topics:
diffusion
,
lipids
,
nonesterified fatty acids
,
tissue membrane
Diabetes December 1999, Vol.48, 2255-2269. doi:https://doi.org/10.2337/diabetes.48.12.2255
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Topics:
exenatide
,
glucose tolerance
,
pancreatic beta cell
,
rats
Diabetes December 1999, Vol.48, 2270-2276. doi:https://doi.org/10.2337/diabetes.48.12.2270
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.
M Federici; A Giaccari; M L Hribal; B Giovannone; D Lauro; L Morviducci; L Pastore; G Tamburrano; R Lauro; G Sesti
Topics:
glucose
,
hexosamines
,
insulin
,
insulin-like growth factor i
Diabetes December 1999, Vol.48, 2277-2285. doi:https://doi.org/10.2337/diabetes.48.12.2277
Hypothalamic neuronal histamine as a target of leptin in feeding behavior.
Topics:
feeding behaviors
,
histamine
,
hypothalamus
,
leptin
Diabetes December 1999, Vol.48, 2286-2291. doi:https://doi.org/10.2337/diabetes.48.12.2286
Effects of graft-versus-host reaction on intrahepatic islet transplants.
Topics:
graft vs host reaction
,
tissue transplants
,
adverse effects
,
antigens, cd15
,
blood glucose
Diabetes December 1999, Vol.48, 2292-2299. doi:https://doi.org/10.2337/diabetes.48.12.2292
Immunotherapy of NOD mice with bone marrow-derived dendritic cells.
Topics:
dendritic cells
,
immunotherapy
,
mice, inbred nod
,
granulocyte-macrophage colony-stimulating factor
,
peptides
Diabetes December 1999, Vol.48, 2300-2308. doi:https://doi.org/10.2337/diabetes.48.12.2300
Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes: effects on insulin release from human islets.
C Pupilli; S Giannini; P Marchetti; R Lupi; A Antonelli; F Malavasi; S Takasawa; H Okamoto; E Ferrannini
Topics:
adenosine diphosphate ribose
,
autoantibodies
,
cd38
,
hydrolase
,
insulin
Diabetes December 1999, Vol.48, 2309-2315. doi:https://doi.org/10.2337/diabetes.48.12.2309
Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetes.
Topics:
antibodies
,
diabetes mellitus, type 1
,
pancreatic enzyme
Diabetes December 1999, Vol.48, 2316-2323. doi:https://doi.org/10.2337/diabetes.48.12.2316
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Topics:
cytotoxin
,
pancreatic beta cell
,
insulin
,
streptozocin
Diabetes December 1999, Vol.48, 2324-2332. doi:https://doi.org/10.2337/diabetes.48.12.2324
Early prophylaxis with recombinant human interleukin-11 prevents spontaneous diabetes in NOD mice.
F Nicoletti; P Zaccone; I Conget; R Gomis; C Möller; P L Meroni; K Bendtzen; W Trepicchio; S Sandler
Topics:
interleukin-11
,
mice, inbred nod
Diabetes December 1999, Vol.48, 2333-2339. doi:https://doi.org/10.2337/diabetes.48.12.2333
A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts.
Topics:
endocrine pancreas
,
rejection (psychology)
,
suidae
,
t-lymphocytes
,
transplantation, heterologous
Diabetes December 1999, Vol.48, 2340-2348. doi:https://doi.org/10.2337/diabetes.48.12.2340
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
J C Chapman; N H McClenaghan; K E Cosgrove; M N Hashmi; R M Shepherd; A N Giesberts; S J White; C Ammälä; P R Flatt; M J Dunne
Topics:
insulin
,
katp channels
,
pancreatic beta cell
Diabetes December 1999, Vol.48, 2349-2357. doi:https://doi.org/10.2337/diabetes.48.12.2349
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.
Topics:
exenatide
,
glucagon
,
glucagon-like peptide 1
,
insulin
,
pancreas
Diabetes December 1999, Vol.48, 2358-2366. doi:https://doi.org/10.2337/diabetes.48.12.2358
Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.
Topics:
insulin secretion, impaired
,
pancreas
,
snare instrument
Diabetes December 1999, Vol.48, 2367-2373. doi:https://doi.org/10.2337/diabetes.48.12.2367
Oscillations of insulin secretion can be triggered by imposed oscillations of cytoplasmic Ca2+ or metabolism in normal mouse islets.
Topics:
calcium ions
,
cytoplasm
,
insulin secretion
,
metabolism
,
mice
Diabetes December 1999, Vol.48, 2374-2382. doi:https://doi.org/10.2337/diabetes.48.12.2374
Increases in phosphorylation of the myosin II heavy chain, but not regulatory light chains, correlate with insulin secretion in rat pancreatic islets and RINm5F cells.
Topics:
endocrine pancreas
,
insulin secretion
,
myosin type ii
,
phosphorylation
Diabetes December 1999, Vol.48, 2383-2389. doi:https://doi.org/10.2337/diabetes.48.12.2383
Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans.
Topics:
diazoxide
,
endocrine pancreas
,
somatostatin-secreting cells
,
tolbutamide
Diabetes December 1999, Vol.48, 2390-2397. doi:https://doi.org/10.2337/diabetes.48.12.2390
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
H Kaneto; Y Kajimoto; J Miyagawa; T Matsuoka; Y Fujitani; Y Umayahara; T Hanafusa; Y Matsuzawa; Y Yamasaki; M Hori
Topics:
antioxidants
,
glucose
,
pancreas
,
toxic effect
Diabetes December 1999, Vol.48, 2398-2406. doi:https://doi.org/10.2337/diabetes.48.12.2398
Localization of the O-linked N-acetylglucosamine transferase in rat pancreas.
Topics:
acetylglucosamine
,
pancreas
,
transferase
Diabetes December 1999, Vol.48, 2407-2413. doi:https://doi.org/10.2337/diabetes.48.12.2407
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients.
Topics:
insulin
,
metformin
,
troglitazone
Diabetes December 1999, Vol.48, 2414-2421. doi:https://doi.org/10.2337/diabetes.48.12.2414
Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both?
A Bavdekar; C S Yajnik; C H Fall; S Bapat; A N Pandit; V Deshpande; S Bhave; S D Kellingray; C Joglekar
Topics:
child
,
insulin resistance
,
birth weight
Diabetes December 1999, Vol.48, 2422-2429. doi:https://doi.org/10.2337/diabetes.48.12.2422
Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes.
Topics:
diabetes mellitus, type 2
,
gestational diabetes
,
pregnancy
Diabetes December 1999, Vol.48, 2430-2436. doi:https://doi.org/10.2337/diabetes.48.12.2430
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.
Topics:
aorta
,
biopterin
,
endothelium
,
insulin
,
metabolism
Diabetes December 1999, Vol.48, 2437-2445. doi:https://doi.org/10.2337/diabetes.48.12.2437
Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillaries.
C G Schalkwijk; N Ligtvoet; H Twaalfhoven; A Jager; H G Blaauwgeers; R O Schlingemann; L Tarnow; H H Parving; C D Stehouwer; V W van Hinsbergh
Topics:
albumins
,
blood capillaries
,
diabetic nephropathy
,
endothelium
Diabetes December 1999, Vol.48, 2446-2453. doi:https://doi.org/10.2337/diabetes.48.12.2446
Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy.
Topics:
apoptosis
,
gene expression
,
hyperglycemia
,
mice
,
neural tube defects
Diabetes December 1999, Vol.48, 2454-2462. doi:https://doi.org/10.2337/diabetes.48.12.2454
Pathophysiological and genetic characterization of the major diabetes locus in GK rats.
Diabetes December 1999, Vol.48, 2463-2470. doi:https://doi.org/10.2337/diabetes.48.12.2463
A transcriptional repressor regulates mouse GLUT4 gene expression during the differentiation of 3T3-L1 cells.
Topics:
gene expression
,
mice
,
transcriptional repression
Diabetes December 1999, Vol.48, 2471-2474. doi:https://doi.org/10.2337/diabetes.48.12.2471
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
T M Frayling; M Walker; M I McCarthy; J C Evans; L I Allen; S Lynn; S Ayres; B Millauer; C Turner; R C Turner; M J Sampson; G A Hitman; S Ellard; A T Hattersley
Topics:
diabetes mellitus, type 2
,
genes
Diabetes December 1999, Vol.48, 2475-2479. doi:https://doi.org/10.2337/diabetes.48.12.2475
