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Volume 48, Issue 4

1 April 1999

ISSN 0012-1797

EISSN 1939-327X

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CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis.

R A Easom

Abstract

View articletitled, CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis.

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Topics: cavernous malformations, cerebral , cell adhesion molecules , complementary therapies , confusion assessment method , exocytosis

Diabetes April 1999, Vol.48, 675-684. doi:https://doi.org/10.2337/diabetes.48.4.675

DNA demethylation during the differentiation of 3T3-L1 cells affects the expression of the mouse GLUT4 gene.

N Yokomori; M Tawata; T Onaya

Abstract

View articletitled, DNA demethylation during the differentiation of 3T3-L1 cells affects the expression of the mouse GLUT4 gene.

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Topics: dna demethylation , genes , mice , gel

Diabetes April 1999, Vol.48, 685-690. doi:https://doi.org/10.2337/diabetes.48.4.685

Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate.

A Gagnon; C S Chen; A Sorisky

Abstract

View articletitled, Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate.

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Topics: insulin , phosphatidylinositols , proto-oncogene proteins c-akt

Diabetes April 1999, Vol.48, 691-698. doi:https://doi.org/10.2337/diabetes.48.4.691

Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.

J Rieusset; F Andreelli; D Auboeuf; M Roques; P Vallier; J P Riou; J Auwerx; M Laville; H Vidal

Abstract

View articletitled, Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.

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Topics: adipocytes , insulin , peroxisome

Diabetes April 1999, Vol.48, 699-705. doi:https://doi.org/10.2337/diabetes.48.4.699

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.

M Flodström; B Tyrberg; D L Eizirik; S Sandler

Abstract

View articletitled, Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.

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Topics: mice , nitric oxide , streptozocin

Diabetes April 1999, Vol.48, 706-713. doi:https://doi.org/10.2337/diabetes.48.4.706

Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects.

C S Mao; N Berman; K Roberts; E Ipp

Abstract

View articletitled, Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects.

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Topics: glucose , insulin , plasma

Diabetes April 1999, Vol.48, 714-721. doi:https://doi.org/10.2337/diabetes.48.4.714

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

F X Jiang; D S Cram; H J DeAizpurua; L C Harrison

Abstract

View articletitled, Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

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Topics: fetus , laminin , mice , pancreas

Diabetes April 1999, Vol.48, 722-730. doi:https://doi.org/10.2337/diabetes.48.4.722

Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes.

R Nesher; D J Gross; M Y Donath; E Cerasi; N Kaiser

Abstract

View articletitled, Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes.

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Topics: animal model , diabetes mellitus, type 2 , dietary factors , genetics , pancreatic beta cell

Diabetes April 1999, Vol.48, 731-737. doi:https://doi.org/10.2337/diabetes.48.4.731

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

M Y Donath; D J Gross; E Cerasi; N Kaiser

Abstract

View articletitled, Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

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Topics: apoptosis , endocrine pancreas , hyperglycemia , pancreatic beta cell

Diabetes April 1999, Vol.48, 738-744. doi:https://doi.org/10.2337/diabetes.48.4.738

Gene transfer to human pancreatic endocrine cells using viral vectors.

G Leibowitz; G M Beattie; T Kafri; V Cirulli; A D Lopez; A Hayek; F Levine

Abstract

View articletitled, Gene transfer to human pancreatic endocrine cells using viral vectors.

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Topics: endocrine cells , gene transfer techniques , pancreas , viral vector

Diabetes April 1999, Vol.48, 745-753. doi:https://doi.org/10.2337/diabetes.48.4.745

Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo.

J Fernandez; M Valdeolmillos

Abstract

View articletitled, Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo.

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Topics: amides , electrical activity of brain , glucagon-like peptide 1 , glucose , pancreas

Diabetes April 1999, Vol.48, 754-757. doi:https://doi.org/10.2337/diabetes.48.4.754

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

F P O'Harte; M H Mooney; P R Flatt

Abstract

View articletitled, NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

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Topics: gastric inhibitory polypeptide , hypoglycemic agents , peptide hydrolases

Diabetes April 1999, Vol.48, 758-765. doi:https://doi.org/10.2337/diabetes.48.4.758

Free fatty acids impair hepatic insulin extraction in vivo.

S R Wiesenthal; H Sandhu; R H McCall; V Tchipashvili; H Yoshii; K Polonsky; Z Q Shi; G F Lewis; A Mari; A Giacca

Abstract

View articletitled, Free fatty acids impair hepatic insulin extraction in vivo.

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Topics: insulin , nonesterified fatty acids

Diabetes April 1999, Vol.48, 766-774. doi:https://doi.org/10.2337/diabetes.48.4.766

Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle.

T S Tsao; A E Stenbit; S M Factor; W Chen; L Rossetti; M J Charron

Abstract

View articletitled, Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle.

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Topics: ablation , animals, transgenic , gene complementation , heterozygote , insulin resistance

Diabetes April 1999, Vol.48, 775-782. doi:https://doi.org/10.2337/diabetes.48.4.775

Inhibition of LDL oxidation in vitro but not ex vivo by troglitazone.

R S Crawford; S R Mudaliar; R R Henry; A Chait

Abstract

View articletitled, Inhibition of LDL oxidation in vitro but not ex vivo by troglitazone.

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Topics: loudness discomfort level , low-density lipoproteins , oxidation , troglitazone

Diabetes April 1999, Vol.48, 783-790. doi:https://doi.org/10.2337/diabetes.48.4.783

Gluconeogenesis in very low birth weight infants receiving total parenteral nutrition.

A L Sunehag; M W Haymond; R J Schanler; P J Reeds; D M Bier

Abstract

View articletitled, Gluconeogenesis in very low birth weight infants receiving total parenteral nutrition.

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Topics: gluconeogenesis , infant, very low birth weight , total parenteral nutrition

Diabetes April 1999, Vol.48, 791-800. doi:https://doi.org/10.2337/diabetes.48.4.791

Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats.

F Giorgino; F Logoluso; A M Davalli; R Napoli; L Laviola; M F Hirshman; E S Horton; G C Weir; R J Smith

Abstract

View articletitled, Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats.

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Topics: 1-phosphatidylinositol 3-kinase , insulin receptor , islets of langerhans transplantation , myocardium , phosphorylation

Diabetes April 1999, Vol.48, 801-812. doi:https://doi.org/10.2337/diabetes.48.4.801

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment.

P Wentzel; N Welsh; U J Eriksson

Abstract

View articletitled, Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment.

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Topics: cyclooxygenase-2 , dinoprostone , embryo , gene expression , lipid peroxidation

Diabetes April 1999, Vol.48, 813-820. doi:https://doi.org/10.2337/diabetes.48.4.813

Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.

J Westerbacka; S Vehkavaara; R Bergholm; I Wilkinson; J Cockcroft; H Yki-Järvinen

Abstract

View articletitled, Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.

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Topics: arterial stiffness , insulin , obesity

Diabetes April 1999, Vol.48, 821-827. doi:https://doi.org/10.2337/diabetes.48.4.821

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

D G Baskin; J F Breininger; M W Schwartz

Abstract

View articletitled, Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

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Topics: fasting , hypothalamus , leptin , neurons , neuropeptide y

Diabetes April 1999, Vol.48, 828-833. doi:https://doi.org/10.2337/diabetes.48.4.828

Effect of insulin on fat metabolism during and after normal pregnancy.

E Sivan; C J Homko; X Chen; E A Reece; G Boden

Abstract

View articletitled, Effect of insulin on fat metabolism during and after normal pregnancy.

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Topics: fat metabolism , insulin , normal pregnancy

Diabetes April 1999, Vol.48, 834-838. doi:https://doi.org/10.2337/diabetes.48.4.834

Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.

B H Goodpaster; D E Kelley; R R Wing; A Meier; F L Thaete

Abstract

View articletitled, Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.

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Topics: body fat distribution , insulin sensitivity , obesity , weight reduction

Diabetes April 1999, Vol.48, 839-847. doi:https://doi.org/10.2337/diabetes.48.4.839

Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes.

A H Xiang; R K Peters; E Trigo; S L Kjos; W P Lee; T A Buchanan

Abstract

View articletitled, Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes.

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Topics: diabetes mellitus, type 2 , late stage of pregnancy

Diabetes April 1999, Vol.48, 848-854. doi:https://doi.org/10.2337/diabetes.48.4.848

Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.

K K Yerneni; W Bai; B V Khan; R M Medford; R Natarajan

Abstract

View articletitled, Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.

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Topics: hyperglycemia , muscle, smooth, vascular , transcription factor

Diabetes April 1999, Vol.48, 855-864. doi:https://doi.org/10.2337/diabetes.48.4.855

Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs.

P Fioretto; M W Steffes; J Barbosa; S S Rich; M E Miller; M Mauer

Abstract

View articletitled, Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs.

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Topics: diabetic nephropathy , kidney glomerulus

Diabetes April 1999, Vol.48, 865-869. doi:https://doi.org/10.2337/diabetes.48.4.865

Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial.

V M Monnier; O Bautista; D Kenny; D R Sell; J Fogarty; W Dahms; P A Cleary; J Lachin; S Genuth

Abstract

View articletitled, Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial.

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Topics: collagen , dcct trial , diabetes mellitus complications , diabetes mellitus, type 1 , glycation

Diabetes April 1999, Vol.48, 870-880. doi:https://doi.org/10.2337/diabetes.48.4.870

Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy.

P Fernyhough; A Gallagher; S A Averill; J V Priestley; L Hounsom; J Patel; D R Tomlinson

Abstract

View articletitled, Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy.

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Topics: diabetic neuropathies , neurons, afferent , phosphorylation , rats , animal model

Diabetes April 1999, Vol.48, 881-889. doi:https://doi.org/10.2337/diabetes.48.4.881

Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue.

P E Morange; J Aubert; F Peiretti; H R Lijnen; P Vague; M Verdier; R Négrel; I Juhan-Vague; M C Alessi

Abstract

View articletitled, Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue.

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Topics: adipose tissue , glucocorticoids , insulin , plasminogen activator inhibitor 1

Diabetes April 1999, Vol.48, 890-895. doi:https://doi.org/10.2337/diabetes.48.4.890

Effect of glycemia on mortality in Pima Indians with type 2 diabetes.

M L Sievers; P H Bennett; R G Nelson

Abstract

View articletitled, Effect of glycemia on mortality in Pima Indians with type 2 diabetes.

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Topics: diabetes mellitus, type 2

Diabetes April 1999, Vol.48, 896-902. doi:https://doi.org/10.2337/diabetes.48.4.896

Pivotal role of nitric oxide in the control of blood pressure after leptin administration.

G Frühbeck

Abstract

View articletitled, Pivotal role of nitric oxide in the control of blood pressure after leptin administration.

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Topics: blood pressure , leptin , nitric oxide

Diabetes April 1999, Vol.48, 903-908. doi:https://doi.org/10.2337/diabetes.48.4.903

Familial clustering of diabetic nephropathy in Brazilian type 2 diabetic patients.

L H Canani; F Gerchman; J L Gross

Abstract

View articletitled, Familial clustering of diabetic nephropathy in Brazilian type 2 diabetic patients.

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Topics: diabetic nephropathy

Diabetes April 1999, Vol.48, 909-913. doi:https://doi.org/10.2337/diabetes.48.4.909

Intermediate expansions of a GAA repeat in the frataxin gene are not associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians.

L T Dalgaard; T Hansen; S A Urhammer; J O Clausen; H Eiberg; O Pedersen

Abstract

View articletitled, Intermediate expansions of a GAA repeat in the frataxin gene are not associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians.

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Topics: diabetes mellitus, type 2 , genes , glucose , pancreatic beta cell

Diabetes April 1999, Vol.48, 914-917. doi:https://doi.org/10.2337/diabetes.48.4.914

Expression of naturally occurring variants in the muscle glycogen synthase gene.

M Orho-Melander; H Shimomura; T Sanke; S K Rasmussen; K Nanjo; O Pedersen; L C Groop

View articletitled, Expression of naturally occurring variants in the muscle glycogen synthase gene.

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Topics: genes , glycogen (starch) synthase

Diabetes April 1999, Vol.48, 918-920. doi:https://doi.org/10.2337/diabetes.48.4.918

Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young.

S Ellard; M P Bulman; T M Frayling; L I Allen; M J Dronsfield; C J Tack; A T Hattersley

View articletitled, Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young.

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Topics: exons , genes , hepatocytes , maturity onset diabetes mellitus in young , mutation

Diabetes April 1999, Vol.48, 921-923. doi:https://doi.org/10.2337/diabetes.48.4.921

Altered beta-cell characteristics in impaired glucose tolerant carriers of a GAA trinucleotide repeat polymorphism in the frataxin gene.

L M t Hart; J B Ruige; J M Dekker; C D Stehouwer; J A Maassen; R J Heine

Abstract

View articletitled, Altered beta-cell characteristics in impaired glucose tolerant carriers of a GAA trinucleotide repeat polymorphism in the frataxin gene.

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Topics: genes , glucose , pancreatic beta cell , polymorphism , trinucleotide repeats

Diabetes April 1999, Vol.48, 924-926. doi:https://doi.org/10.2337/diabetes.48.4.924

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Y Ihara; S Toyokuni; K Uchida; H Odaka; T Tanaka; H Ikeda; H Hiai; Y Seino; Y Yamada

Abstract

View articletitled, Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Topics: diabetes mellitus, type 2 , hyperglycemia , oxidative stress , pancreas , rats

Diabetes April 1999, Vol.48, 927-932. doi:https://doi.org/10.2337/diabetes.48.4.927

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